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Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.105-116

2001

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Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy, 1999-06, Vol.43 (6), p.1340-1346

1999

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MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4201-4204

2003

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4205-4208

2003

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

Bioorganic & medicinal chemistry, 2007-11, Vol.15 (22), p.7087-7097

2007

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Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (5), p.763-766

2002

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Stereochemical Elucidation and Total Synthesis of Dihydropacidamycin D, a Semisynthetic Pacidamycin

Journal of the American Chemical Society, 2001-02, Vol.123 (5), p.870-874

2001

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In Vivo Antibacterial Activity of RWJ-54428, a New Cephalosporin with Activity against Gram-Positive Bacteria

Antimicrobial Agents and Chemotherapy, 2003-01, Vol.47 (1), p.43-47

2003

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents

Bioorganic & medicinal chemistry, 2006-12, Vol.14 (24), p.8506-8518

2006

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Inhibitors of Efflux Pumps in Pseudomonas aeruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin

Journal of medicinal chemistry, 1999-12, Vol.42 (24), p.4928-4931

1999

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An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

Molecules (Basel, Switzerland), 2001-11, Vol.6 (12), p.959-963

2001

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position

Bioorganic & medicinal chemistry, 2006-03, Vol.14 (6), p.1993-2004

2006

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Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (16), p.2755-2758

2003

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.475-479

2004

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Synthesis of Thieno[2,3-d]-1,3-dithiol-2-thiones from Thieno[2,3-d]-1,2,3-thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions

Molecules (Basel, Switzerland), 2002-02, Vol.7 (2), p.145-154

2002

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Discovery of RWJ-54428 (MC-02, 479), a New Cephalosporin Active Against Resistant Gram-positive Bacteria

The Journal of Antibiotics, 2000/11/25, Vol.53(11), pp.1272-1281

2000

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (10), p.2493-2497

2004

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Synthetic dihydropacidamycin antibiotics: A modified spectrum of activity for the pacidamycin class

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3305-3309

2003

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Synthesis and Antimicrobial Evaluation of TAN-1057A/B Analogs

The Journal of Antibiotics, 1998/02/25, Vol.51(2), pp.189-201

1998

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Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (5), p.663-667

2001

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Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines

Journal of medicinal chemistry, 1994-01, Vol.37 (1), p.184-188

1994

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What's new in the antibiotic pipeline

Current Opinion in Microbiology, 1999-10, Vol.2 (5), p.475-482

1999

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Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux

Recent patents on anti-infective drug discovery, 2006-06, Vol.1 (2), p.157-175

2006

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Inhibitors of Efflux Pumps in Pseudomonas a eruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin

Journal of medicinal chemistry, 1999-12, Vol.42 (24), p.4928-4931

1999

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"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3205-3211

1994

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Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy

Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa

MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

Stereochemical Elucidation and Total Synthesis of Dihydropacidamycin D, a Semisynthetic Pacidamycin

In Vivo Antibacterial Activity of RWJ-54428, a New Cephalosporin with Activity against Gram-Positive Bacteria

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents

Inhibitors of Efflux Pumps in Pseudomonas aeruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin

An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Synthesis of Thieno[2,3-d]-1,3-dithiol-2-thiones from Thieno[2,3-d]-1,2,3-thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions

Discovery of RWJ-54428 (MC-02, 479), a New Cephalosporin Active Against Resistant Gram-positive Bacteria

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Synthetic dihydropacidamycin antibiotics: A modified spectrum of activity for the pacidamycin class

Synthesis and Antimicrobial Evaluation of TAN-1057A/B Analogs

Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines

What's new in the antibiotic pipeline

Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux

Inhibitors of Efflux Pumps in Pseudomonas a eruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin

"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides

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