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Pharmaceutical approach to somatic gene therapy

Pharmaceutical research, 1996-11, Vol.13 (11), p.1595-1614

LEDLEY, F. D

1996

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Why commercialization of gene therapy stalled; examining the life cycles of gene therapy technologies

Gene therapy, 2014-02, Vol.21 (2), p.188-194

2014

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Mouse Hepatocytes Migrate to Liver Parenchyma and Function Indefinitely after Intrasplenic Transplantation

Proceedings of the National Academy of Sciences - PNAS, 1991-02, Vol.88 (4), p.1217-1221

1991

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Nonviral gene therapy: the promise of genes as pharmaceutical products

Human gene therapy, 1995-09, Vol.6 (9), p.1129-1144

Ledley, F D

1995

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Can pharmacogenomics make a difference in drug development?

Nature biotechnology, 1999-08, Vol.17 (8), p.731-731

Ledley, Fred D

1999

Volltextzugriff (PDF)

Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases

Proceedings of the National Academy of Sciences - PNAS, 1987-08, Vol.84 (16), p.5530-5534

1987

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Hepatic gene therapy: Present and future

Hepatology (Baltimore, Md.), 1993-11, Vol.18 (5), p.1263-1273

Ledley, Fred D.

1993

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Clustering of mutations in methylmalonyl CoA mutase associated with mut- methylmalonic acidemia

American journal of human genetics, 1994-07, Vol.55 (1), p.42-50

1994

Volltextzugriff (PDF)

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II

Cancer research (Chicago, Ill.), 1991-09, Vol.51 (17), p.4729-4731

1991

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Why pharmacogenomics? Why now?

Nature biotechnology, 1998-06, Vol.16 (6), p.492-493

1998

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Retroviral Gene Transfer into Primary Hepatocytes: Implications for Genetic Therapy of Liver-Specific Functions

Proceedings of the National Academy of Sciences - PNAS, 1987-08, Vol.84 (15), p.5335-5339

1987

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Retroviral-Mediated Gene Transfer and Expression of Human Phenylalanine Hydroxylase in Primary Mouse Hepatocytes

Proceedings of the National Academy of Sciences - PNAS, 1988-11, Vol.85 (21), p.8146-8150

1988

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Factors influencing the interests, career paths, and research activities of recent graduates from an academic, pediatric residency program

Pediatrics (Evanston), 1993-09, Vol.92 (3), p.436

1993

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GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria

Nucleic acids research, 1987-07, Vol.15 (14), p.5613-5628

1987

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Transduction of Primary Human Hepatocytes with Amphotropic and Xenotropic Retroviral Vectors

Proceedings of the National Academy of Sciences - PNAS, 1992-10, Vol.89 (19), p.8981-8985

1992

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"Our study is man" (and woman)

Human gene therapy, 1996-06, Vol.7 (10), p.1193-1195

1996

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Molecular Cloning of L-methylmalonyl-CoA Mutase: Gene Transfer and Analysis of mut Cell Lines

Proceedings of the National Academy of Sciences - PNAS, 1988-05, Vol.85 (10), p.3518-3521

1988

Volltextzugriff (PDF)

Assessing risk

Human gene therapy, 1995-05, Vol.6 (5), p.551-552

1995

Volltextzugriff (PDF)

Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts

American journal of human genetics, 1993, Vol.52 (1), p.144-151

1993

Volltextzugriff (PDF)

Are contemporary methods for somatic gene therapy suitable for clinical applications?

Clinical and investigative medicine, 1993-02, Vol.16 (1), p.78

Ledley, F D

1993

Volltextzugriff (PDF)

Genomic structure of murine methylmalonyl-CoA mutase : evidence for genetic and epigenetic mechanisms determining enzyme activity

Biochemical journal, 1993-12, Vol.296 (3), p.663-670

1993

Volltextzugriff (PDF)

Biochemical characterization of recombinant human phenylalanine hydroxylase produced in Escherichia coli

The Journal of biological chemistry, 1987-02, Vol.262 (5), p.2228-2233

1987

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Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene

Biochemistry (Easton), 1986-02, Vol.25 (4), p.743-749

1986

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Mapping of human methylmalonyl CoA mutase (MUT) locus on chromosome 6

American journal of human genetics, 1988-06, Vol.42 (6), p.839-846

1988

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Molecular Basis for Dysfunction of Some Mutant Forms of Methylmalonyl-CoA Mutase: Deductions from the Structure of Methionine Synthase

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (11), p.5550-5555

1996

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Pharmaceutical approach to somatic gene therapy

Why commercialization of gene therapy stalled; examining the life cycles of gene therapy technologies

Mouse Hepatocytes Migrate to Liver Parenchyma and Function Indefinitely after Intrasplenic Transplantation

Nonviral gene therapy: the promise of genes as pharmaceutical products

Can pharmacogenomics make a difference in drug development?

Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases

Hepatic gene therapy: Present and future

Clustering of mutations in methylmalonyl CoA mutase associated with mut- methylmalonic acidemia

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II

Why pharmacogenomics? Why now?

Retroviral Gene Transfer into Primary Hepatocytes: Implications for Genetic Therapy of Liver-Specific Functions

Retroviral-Mediated Gene Transfer and Expression of Human Phenylalanine Hydroxylase in Primary Mouse Hepatocytes

Factors influencing the interests, career paths, and research activities of recent graduates from an academic, pediatric residency program

GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria

Transduction of Primary Human Hepatocytes with Amphotropic and Xenotropic Retroviral Vectors

"Our study is man" (and woman)

Molecular Cloning of L-methylmalonyl-CoA Mutase: Gene Transfer and Analysis of mut Cell Lines

Assessing risk

Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts

Are contemporary methods for somatic gene therapy suitable for clinical applications?

Genomic structure of murine methylmalonyl-CoA mutase : evidence for genetic and epigenetic mechanisms determining enzyme activity

Biochemical characterization of recombinant human phenylalanine hydroxylase produced in Escherichia coli

Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene

Mapping of human methylmalonyl CoA mutase (MUT) locus on chromosome 6

Molecular Basis for Dysfunction of Some Mutant Forms of Methylmalonyl-CoA Mutase: Deductions from the Structure of Methionine Synthase

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