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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3200-3205

2008

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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B

Biochemistry (Easton), 2003-10, Vol.42 (39), p.11451-11459

2003

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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.920-923

2011

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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.1043-1048

2004

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The C3a receptor antagonist SB 290157 has agonist activity

Immunology Letters, 2005-09, Vol.100 (2), p.139-145

2005

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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.887-892

2010

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Pyridazinones as selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.597-600

2003

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Preparation of ortho-hydroxyalkylanilines as ortho-quinone methide imine precursors via an aminoborane complex

Canadian journal of chemistry, 1995-09, Vol.73 (9), p.1506-1513

1995

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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2319-2322

2004

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Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4897-4905

1995

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Reductive deoxygenation of aryl aldehydes and ketones by tert-butylamine-borane and aluminum chloride

Journal of organic chemistry, 1989-01, Vol.54 (2), p.491-494

1989

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Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase

Journal of medicinal chemistry, 1992-04, Vol.35 (7), p.1299-1318

1992

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One-pot synthesis of precocene I and II and a formal synthesis of robustadial A and B via 2-phenyl-4H-1,3,2-benzodioxaborin

Canadian journal of chemistry, 1994-08, Vol.72 (8), p.1866-1869

1994

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Total synthesis of LTB4 and analogs

Journal of organic chemistry, 1988-01, Vol.53 (2), p.267-275

1988

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Reactions of 2-phenyl-4H-1,3,2-benzodioxaborin, a stable ortho-quinone methide precursor

Canadian journal of chemistry, 1992-06, Vol.70 (6), p.1717-1732

1992

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Synthesis of syn- and anti-3,5-Dihydroxy-6-heptenoates from 2-Deoxy-d-ribose: Intermediates for Polyols Synthesis

Synlett, 2003, Vol.2003 (2), p.215-218

2003

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Synthesis of 3-Alkoxyindoles via Palladium-Catalyzed Intramolecular Cyclization of N-Alkyl ortho-Siloxyallylanilines

Synlett, 1997-11, Vol.1997 (11), p.1312-1314

1997

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ortho-Specific alkylation of phenols via 1,3,2-benzodioxaborins

Canadian journal of chemistry, 1989-09, Vol.67 (9), p.1384-1387

1989

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Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224

Journal of medicinal chemistry, 1989-06, Vol.32 (6), p.1190-1197

1989

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ortho-Hydroxyalkylation of Aminopyridines: A Novel Approach to Heterocycles

Synthesis (Stuttgart), 1999-11, Vol.1999 (11), p.1893-1902

Zakrzewski, Peter

1999

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Syntheses of quinolines, dihydro- and tetrahydroquinolines via ortho-quinone methide imine intermediate

Tetrahedron, 1996-09, Vol.52 (36), p.11705-11724

1996

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Progress towards the decalin portion of (+)-compactin

Tetrahedron: asymmetry, 2002-09, Vol.13 (18), p.1965-1967

2002

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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-11, Vol.9 (22), p.3187-3192

1999

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A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-11, Vol.9 (22), p.3181-3186

1999

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ortho-Quinone Methide Imine: Generation and Diels-Alder Reaction at Room Temperature

Synlett, 1996-07, Vol.1996 (7), p.669-671

1996

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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors

The C3a receptor antagonist SB 290157 has agonist activity

The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

Pyridazinones as selective cyclooxygenase-2 inhibitors

Preparation of ortho-hydroxyalkylanilines as ortho-quinone methide imine precursors via an aminoborane complex

Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme

Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Reductive deoxygenation of aryl aldehydes and ketones by tert-butylamine-borane and aluminum chloride

Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase

One-pot synthesis of precocene I and II and a formal synthesis of robustadial A and B via 2-phenyl-4H-1,3,2-benzodioxaborin

Total synthesis of LTB4 and analogs

Reactions of 2-phenyl-4H-1,3,2-benzodioxaborin, a stable ortho-quinone methide precursor

Synthesis of syn- and anti-3,5-Dihydroxy-6-heptenoates from 2-Deoxy-d-ribose: Intermediates for Polyols Synthesis

Synthesis of 3-Alkoxyindoles via Palladium-Catalyzed Intramolecular Cyclization of N-Alkyl ortho-Siloxyallylanilines

ortho-Specific alkylation of phenols via 1,3,2-benzodioxaborins

Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224

ortho-Hydroxyalkylation of Aminopyridines: A Novel Approach to Heterocycles

Syntheses of quinolines, dihydro- and tetrahydroquinolines via ortho-quinone methide imine intermediate

Progress towards the decalin portion of (+)-compactin

Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

ortho-Quinone Methide Imine: Generation and Diels-Alder Reaction at Room Temperature

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