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A light at the end of the tunnel - from mutation identification to a potential treatment for Alzheimer's disease

Upsala journal of medical sciences, 2023, Vol.128, p.e10316-10

Lannfelt, Lars

2023

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The Amyloid-β Pathway in Alzheimer's Disease

Molecular psychiatry, 2021-10, Vol.26 (10), p.5481-5503

2021

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Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease

Neurotherapeutics, 2023-01, Vol.20 (1), p.195-206

2023

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Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Acta neuropathologica, 2018-07, Vol.136 (1), p.41-56

2018

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A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody

Alzheimer's research & therapy, 2021-04, Vol.13 (1), p.80-14, Article 80

2021

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Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Nature communications, 2016-02, Vol.7 (1), p.10759-10759, Article 10759

2016

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Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

European journal of human genetics : EJHG, 2020-03, Vol.28 (3), p.349-357

2020

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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Theranostics, 2017, Vol.7 (2), p.308-318

2017

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Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (28), p.10323-10328

2014

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Mosaic loss of chromosome Y in leukocytes matters

Nature genetics, 2019-01, Vol.51 (1), p.4-7

2019

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Vascular risk factors and dementia: 40-year follow-up of a population-based cohort

Dementia and geriatric cognitive disorders, 2011-01, Vol.31 (6), p.460-466

2011

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A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils – a new concept for neuroimaging

NeuroImage (Orlando, Fla.), 2017-03, Vol.148, p.55-63

2017

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The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Journal of neuroinflammation, 2018-03, Vol.15 (1), p.98-98, Article 98

2018

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Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

PloS one, 2016-03, Vol.11 (3), p.e0150672-e0150672

2016

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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

The Journal of biological chemistry, 2015-06, Vol.290 (24), p.14904-14914

2015

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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

Neurobiology of disease, 2021-12, Vol.161, p.105543-105543, Article 105543

2021

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Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Neurobiology of disease, 2014-09, Vol.69, p.134-143

2014

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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation

The Journal of neuroscience, 2012-08, Vol.32 (34), p.11750-11762

2012

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Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (35), p.15595-15600

2010

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Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Lancet neurology, 2008, Vol.7 (9), p.779-786

2008

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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Scientific reports, 2024-05, Vol.14 (1), p.10868-15, Article 10868

2024

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CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

Molecular therapy. Nucleic acids, 2018-06, Vol.11 (C), p.429-440

2018

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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia

BMC genomics, 2022-02, Vol.23 (1), p.99-99, Article 99

2022

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Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Journal of neuroinflammation, 2017-12, Vol.14 (1), p.241-241, Article 241

2017

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Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease

Journal of Alzheimer's disease, 2011-01, Vol.27 (4), p.711-722

2011

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A light at the end of the tunnel - from mutation identification to a potential treatment for Alzheimer's disease

The Amyloid-β Pathway in Alzheimer's Disease

Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients

Mosaic loss of chromosome Y in leukocytes matters

Vascular risk factors and dementia: 40-year follow-up of a population-based cohort

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils – a new concept for neuroimaging

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation

Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease

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