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Glucose and mannose analogs inhibit KSHV replication by blocking N‐glycosylation and inducing the unfolded protein response

Journal of medical virology, 2023-01, Vol.95 (1), p.e28314-n/a

2023

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Abstract 1252: Glucose and Mannose sugar analogs negatively affect KSHV replication by inhibiting N-Glycosylation and inducing the Unfolded Protein Response

The Journal of biological chemistry, 2023, Vol.299 (3), p.103079, Article 103079

2023

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The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

Developmental cell, 2022-03, Vol.57 (5), p.654-669.e9

2022

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The evolutionarily conserved Arginyltransferase1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

Developmental cell, 2022-03, Vol.57 (5), p.654-669.e9

2022

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2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2

IUBMB life, 2021-10, Vol.73 (10), p.1198-1204

2021

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Arginyltransferase1 mediates a pVHL‐independent oxygen sensing pathway in mammalian cells

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.02133

2021

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Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

Frontiers in cell and developmental biology, 2020-12, Vol.8, p.603688-603688

2020

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Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

Molecular cancer research, 2020-01, Vol.18 (1), p.105-117

2020

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Ate1 Controls Cellular Warburg Effects by Modifying Hif1a with Arginylation

The FASEB journal, 2019-04, Vol.33 (S1), p.lb312-lb312

2019

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Posttranslational arginylation enzyme Ate1 is a mitochondrial‐derived master regulator that coordinates glycolysis and respiration in the Warburg effect

The FASEB journal, 2018-04, Vol.32 (S1), p.791.19-791.19

2018

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Protein Modifying Enzyme Ate1 Controls Cellular Warburg Effects

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

Oncotarget, 2016-06, Vol.7 (24), p.36461-36473

2016

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2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3β Activation

Molecular cancer therapeutics, 2016-02, Vol.15 (2), p.264-275

2016

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2-DEOXY-GLUCOSE DOWN REGULATES ENDOTHELIAL AKT AND ERK VIA INTERFERENCE WITH N-LINKED GLYCOSYLATION, INDUCTION OF ENDOPLASMIC RETICULUM STRESS AND GSK-3β ACTIVATION

Molecular cancer therapeutics, 2015-12, Vol.15 (2), p.264-275

2015

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Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Leukemia research, 2015-11, Vol.39 (11), p.1246-1254

2015

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ATF 4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

The FEBS journal, 2015-09, Vol.282 (18), p.3647-3658

2015

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ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

The FEBS journal, 2015-09, Vol.282 (18), p.3647-3658

2015

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Abstract 1382: 2-Deoxy-glucose downregulates endothelial Akt and Erk via interference with N-linked glycosylation, induction of endoplasmic reticulum stress, and GSK-3β activation

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1382-1382

2015

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BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

Blood, 2014-12, Vol.124 (21), p.916-916

2014

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Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

Cancer chemotherapy and pharmacology, 2014-02, Vol.73 (2), p.349-361

2014

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The wonders of 2‐deoxy‐d‐glucose

IUBMB life, 2014-02, Vol.66 (2), p.110-121

2014

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Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

Cancer chemotherapy and pharmacology, 2014-02, Vol.73 (2), p.417-427

2014

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Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

Cancer chemotherapy and pharmacology, 2013-07, Vol.72 (1), p.251-262

2013

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Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

Biochemical pharmacology, 2013-05, Vol.85 (10), p.1463-1477

2013

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Models and discovery strategies for new therapies of retinoblastoma

Expert opinion on drug discovery, 2013-04, Vol.8 (4), p.383-394

2013

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Glucose and mannose analogs inhibit KSHV replication by blocking N‐glycosylation and inducing the unfolded protein response

Abstract 1252: Glucose and Mannose sugar analogs negatively affect KSHV replication by inhibiting N-Glycosylation and inducing the Unfolded Protein Response

The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

The evolutionarily conserved Arginyltransferase1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2

Arginyltransferase1 mediates a pVHL‐independent oxygen sensing pathway in mammalian cells

Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

Ate1 Controls Cellular Warburg Effects by Modifying Hif1a with Arginylation

Posttranslational arginylation enzyme Ate1 is a mitochondrial‐derived master regulator that coordinates glycolysis and respiration in the Warburg effect

Protein Modifying Enzyme Ate1 Controls Cellular Warburg Effects

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3β Activation

2-DEOXY-GLUCOSE DOWN REGULATES ENDOTHELIAL AKT AND ERK VIA INTERFERENCE WITH N-LINKED GLYCOSYLATION, INDUCTION OF ENDOPLASMIC RETICULUM STRESS AND GSK-3β ACTIVATION

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

ATF 4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

Abstract 1382: 2-Deoxy-glucose downregulates endothelial Akt and Erk via interference with N-linked glycosylation, induction of endoplasmic reticulum stress, and GSK-3β activation

BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

The wonders of 2‐deoxy‐d‐glucose

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

Models and discovery strategies for new therapies of retinoblastoma

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