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New aspects of natural products in drug discovery

Trends in microbiology (Regular ed.), 2007-06, Vol.15 (6), p.279-289

Lam, Kin S

2007

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2175-2180

2009

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Discovery of novel metabolites from marine actinomycetes

Current opinion in microbiology, 2006-06, Vol.9 (3), p.245-251

Lam, Kin S

2006

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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Journal of natural products (Washington, D.C.), 2008-10, Vol.71 (10), p.1732-1737

2008

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Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

Marine Drugs, 2010-03, Vol.8 (4), p.835-880

2010

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Journal of natural products (Washington, D.C.), 2004-08, Vol.67 (8), p.1400-1402

2004

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Stabilization effect of resin on the production of potent proteasome inhibitor NPI-0052 during submerged fermentation of Salinispora tropica

Journal of antibiotics, 2007-07, Vol.60 (7), p.469-472

2007

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Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp: I. Taxonomy, Fermentation and Biological Activities

The Journal of Antibiotics, 2003/03/25, Vol.56(3), pp.226-231

2003

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Drug discovery from natural products

Journal of industrial microbiology & biotechnology, 2006-07, Vol.33 (7), p.523-531

2006

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Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp: II. Isolation, Characterization, and Structure Determination

The Journal of Antibiotics, 2003/03/25, Vol.56(3), pp.232-242

2003

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Conformation and Absolute Configuration of Nocathiacin I Determined by NMR Spectroscopy and Chiral Capillary Electrophoresis

Journal of the American Chemical Society, 2002-06, Vol.124 (25), p.7284-7285

2002

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Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Journal of antibiotics, 2007-01, Vol.60 (1), p.13-19

2007

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Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs

Applied microbiology and biotechnology, 2008-04, Vol.78 (5), p.827-832

2008

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Growth of Salinispora tropica strains CNB440, CNB476, and NPS21184 in nonsaline, low-sodium media

Applied microbiology and biotechnology, 2008-10, Vol.80 (5), p.873-880

2008

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low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184

Applied microbiology and biotechnology, 2008-04, Vol.78 (5), p.821-826

2008

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Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Journal of natural products (Washington, D.C.), 2007-09, Vol.70 (9), p.1454-1457

2007

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Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Journal of natural products (Washington, D.C.), 2005-05, Vol.68 (5), p.780-783

2005

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Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.269-276

2007

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Antiprotealide Is a Natural Product

Journal of natural products (Washington, D.C.), 2009-02, Vol.72 (2), p.295-297

2009

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Purification, cloning, and functional expression of phenylalanine aminomutase: The first committed step in Taxol side-chain biosynthesis

Archives of biochemistry and biophysics, 2005-06, Vol.438 (1), p.1-10

2005

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Synthesis and antibacterial activity of nocathiacin I analogues

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3545-3549

2006

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Seawater requirement for the production of lipoxazolidinones by marine actinomycete strain NPS8920

Journal of industrial microbiology & biotechnology, 2008-07, Vol.35 (7), p.761-765

2008

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Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

Applied microbiology and biotechnology, 2007-07, Vol.75 (5), p.999-1005

2007

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New aspects of natural products in drug discovery

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Discovery of novel metabolites from marine actinomycetes

Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Stabilization effect of resin on the production of potent proteasome inhibitor NPI-0052 during submerged fermentation of Salinispora tropica

Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp: I. Taxonomy, Fermentation and Biological Activities

Drug discovery from natural products

Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp: II. Isolation, Characterization, and Structure Determination

Conformation and Absolute Configuration of Nocathiacin I Determined by NMR Spectroscopy and Chiral Capillary Electrophoresis

Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs

Growth of Salinispora tropica strains CNB440, CNB476, and NPS21184 in nonsaline, low-sodium media

low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184

Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Antiprotealide Is a Natural Product

Purification, cloning, and functional expression of phenylalanine aminomutase: The first committed step in Taxol side-chain biosynthesis

Synthesis and antibacterial activity of nocathiacin I analogues

Seawater requirement for the production of lipoxazolidinones by marine actinomycete strain NPS8920

Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

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