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Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

ACS medicinal chemistry letters, 2012-12, Vol.3 (12), p.1091-1096

2012

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2―activating mutations

Nature (London), 2012-12, Vol.492 (7427), p.108-112

2012

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Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

Molecular cancer therapeutics, 2006-01, Vol.5 (1), p.160-169

2006

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Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.909-912

2005

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1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.765-770

2005

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A facile method for the synthesis of substituted pyrazolo[3,4- c]pyridines

Tetrahedron letters, 2009-01, Vol.50 (4), p.383-385

2009

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Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3310-3314

2006

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Substituted 1,4-Benzodiazepine-2,5-diones as α-Helix Mimetic Antagonists of the HDM2-p53 Protein-Protein Interaction

Chemical biology & drug design, 2006-03, Vol.67 (3), p.201-205

2006

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Abstract 3260: Identification and synthesis of benzimidazole carboxamides as potent inhibitors of focal adhesion kinase (FAK)

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.3260-3260

2011

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Abstract 4700: A novel selective EZH2 inhibitor exhibits anti-tumor activity in lymphoma with EZH2 activating mutations

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.4700-4700

2012

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Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2939-2939

2012

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Research Article: Substituted 1,4-Benzodiazepine-2,5-diones as alpha -Helix Mimetic Antagonists of the HDM2-p53 Protein-Protein Interaction

Chemical biology & drug design, 2006-03, Vol.67 (3), p.201-205

2006

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ChemInform Abstract: A Facile Method for the Synthesis of Substituted Pyrazolo[3,4-c]pyridines

ChemInform, 2009-05, Vol.40 (18), p.no-no

2009

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Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2―activating mutations

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

A facile method for the synthesis of substituted pyrazolo[3,4- c]pyridines

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design

Substituted 1,4-Benzodiazepine-2,5-diones as α-Helix Mimetic Antagonists of the HDM2-p53 Protein-Protein Interaction

Abstract 3260: Identification and synthesis of benzimidazole carboxamides as potent inhibitors of focal adhesion kinase (FAK)

Abstract 4700: A novel selective EZH2 inhibitor exhibits anti-tumor activity in lymphoma with EZH2 activating mutations

Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3 S )-3-piperidinylmethyl]oxy}-1 H -imidazo[4,5- c ]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Identification of 4-2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-([(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Research Article: Substituted 1,4-Benzodiazepine-2,5-diones as alpha -Helix Mimetic Antagonists of the HDM2-p53 Protein-Protein Interaction

ChemInform Abstract: A Facile Method for the Synthesis of Substituted Pyrazolo[3,4-c]pyridines

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