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Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

Cell, 2013-08, Vol.154 (3), p.556-568

2013

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Adding calorimetric data to decision making in lead discovery: a hot tip

Nature reviews. Drug discovery, 2010-01, Vol.9 (1), p.23-27

2010

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Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

Cell, 2012-06, Vol.149 (7), p.1514-1524

2012

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Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

Biochemical Society transactions, 2010-08, Vol.38 (4), p.888-893

Ladbury, John E

2010

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Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Methods (San Diego, Calif.), 2013-03, Vol.59 (3), p.301-315

2013

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TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Nature immunology, 2015-07, Vol.16 (9), p.970-979

2015

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Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction

Scientific reports, 2021-03, Vol.11 (1), p.6160-6160, Article 6160

2021

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The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

Journal of molecular biology, 2008-12, Vol.384 (4), p.1002-1017

2008

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On-chip Raman spectroscopy of live single cells for the staging of oesophageal adenocarcinoma progression

Scientific reports, 2024-01, Vol.14 (1), p.1761-1761, Article 1761

2024

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H-NS forms a superhelical protein scaffold for DNA condensation

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15728-15732

2010

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Regulation of microRNA expression by the adaptor protein GRB2

Scientific reports, 2023-06, Vol.13 (1), p.9784-15, Article 9784

2023

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Extent of enthalpy–entropy compensation in protein–ligand interactions

Protein science, 2011-09, Vol.20 (9), p.1607-1618

2011

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H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing

Nucleic acids research, 2019-03, Vol.47 (5), p.2666-2680

2019

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A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

Developmental cell, 2014-12, Vol.31 (5), p.614-628

2014

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Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

Nature communications, 2015-06, Vol.6 (1), p.7354-7354, Article 7354

2015

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Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry

Chemical communications (Cambridge, England), 2018, Vol.54 (57), p.7995-7998

2018

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Erythropoietin Stimulates Tumor Growth via EphB4

Cancer cell, 2015-11, Vol.28 (5), p.610-622

2015

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Grb2 binding induces phosphorylation-independent activation of Shp2

Communications biology, 2021-04, Vol.4 (1), p.437-437, Article 437

2021

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FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (33), p.8388-8393

2018

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H-NS is a part of a thermally controlled mechanism for bacterial gene regulation

Biochemical journal, 2005-10, Vol.391 (Pt 2), p.203-213

2005

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A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis

The Journal of biological chemistry, 2015-05, Vol.290 (18), p.11749-11761

2015

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Phase separation enhances probability of receptor signalling and drug targeting

Trends in biochemical sciences (Amsterdam. Regular ed.), 2023-05, Vol.48 (5), p.428-436

2023

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Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity

Biochemical journal, 2016-11, Vol.473 (21), p.3837-3854

2016

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Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.260-266

1999

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Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

Adding calorimetric data to decision making in lead discovery: a hot tip

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

A Landscape of Driver Mutations in Melanoma

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

On-chip Raman spectroscopy of live single cells for the staging of oesophageal adenocarcinoma progression

H-NS forms a superhelical protein scaffold for DNA condensation

Regulation of microRNA expression by the adaptor protein GRB2

Extent of enthalpy–entropy compensation in protein–ligand interactions

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry

Erythropoietin Stimulates Tumor Growth via EphB4

Grb2 binding induces phosphorylation-independent activation of Shp2

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation

A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis

Phase separation enhances probability of receptor signalling and drug targeting

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

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