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inhibitors of apoptosis (IAPs) as cancer targets

Apoptosis (London), 2007-09, Vol.12 (9), p.1543-1568

2007

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Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

Trends in molecular medicine, 2014-11, Vol.20 (11), p.652-665

2014

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Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Nature communications, 2017-02, Vol.8 (1), p.1-15, Article 14278

2017

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Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization

PloS one, 2018-03, Vol.13 (3), p.e0193643-e0193643

2018

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Smac mimetics and innate immune stimuli synergize to promote tumor death

Nature biotechnology, 2014-02, Vol.32 (2), p.182

2014

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LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling

Frontiers in immunology, 2023-04, Vol.14, p.1179827-1179827

2023

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Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Skeletal muscle, 2019-05, Vol.9 (1), p.13-13, Article 13

2019

Volltextzugriff (PDF)

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

Cancer research (Chicago, Ill.), 2009-10, Vol.69 (19), p.7729-7738

2009

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XIAP protection of photoreceptors in animal models of retinitis pigmentosa

PloS one, 2007-03, Vol.2 (3), p.e314-e314

2007

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Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo

Clinical cancer research, 2003-07, Vol.9 (7), p.2826-2836

2003

Volltextzugriff (PDF)

Taking aim with IAP antagonists at triple-negative breast cancer: a moving target no more?

Cell death & disease, 2020-05, Vol.11 (5), p.350-350, Article 350

LaCasse, Eric C

2020

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Pulling the plug on a cancer cell by eliminating XIAP with AEG35156

Cancer letters, 2013-05, Vol.332 (2), p.215-224

LaCasse, Eric C

2013

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Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

Clinical cancer research, 2006-09, Vol.12 (17), p.5231-5241

2006

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Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Molecular & cellular oncology, 2019-07, Vol.6 (4), p.1607456-1607456

2019

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Selective JAK1 inhibitors for the treatment of inflammatory bowel disease

Pharmacology & therapeutics (Oxford), 2023-05, Vol.245, p.108402-108402, Article 108402

2023

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Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression

Molecular therapy. Oncolytics, 2018-09, Vol.10, p.28-39

2018

Volltextzugriff (PDF)

Modulation of immune signalling by inhibitors of apoptosis

Trends in immunology, 2012-11, Vol.33 (11), p.535-545

2012

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Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta

BMC cancer, 2007-03, Vol.7 (1), p.52-52, Article 52

2007

Volltextzugriff (PDF)

The transcription factor SP3 drives TNF-α expression in response to Smac mimetics

Science signaling, 2019-01, Vol.12 (566)

2019

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The inhibitors of apoptosis (IAPs) and their emerging role in cancer

Oncogene, 1998-12, Vol.17 (25), p.3247-3259

1998

Volltextzugriff (PDF)

Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis

Frontiers in immunology, 2014, Vol.5, p.34-34

2014

Volltextzugriff (PDF)

Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists

The International journal of developmental biology, 2015, Vol.59 (1-3), p.141

2015

Volltextzugriff (PDF)

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model

Oncotarget, 2017-01, Vol.8 (2), p.3495-3508

2017

Volltextzugriff (PDF)

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

Oncogene, 2004-10, Vol.23 (49), p.8105-8117

2004

Volltextzugriff (PDF)

The inhibitors of apoptosis (IAPs): Over 20 years of research into life and death

Seminars in cell & developmental biology, 2015-03, Vol.39, p.70-71

2015

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inhibitors of apoptosis (IAPs) as cancer targets

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization

Smac mimetics and innate immune stimuli synergize to promote tumor death

LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

XIAP protection of photoreceptors in animal models of retinitis pigmentosa

Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo

Taking aim with IAP antagonists at triple-negative breast cancer: a moving target no more?

Pulling the plug on a cancer cell by eliminating XIAP with AEG35156

Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Selective JAK1 inhibitors for the treatment of inflammatory bowel disease

Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression

Modulation of immune signalling by inhibitors of apoptosis

Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta

The transcription factor SP3 drives TNF-α expression in response to Smac mimetics

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis

Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

The inhibitors of apoptosis (IAPs): Over 20 years of research into life and death

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