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Choline kinase inhibition in rheumatoid arthritis

Annals of the rheumatic diseases, 2015-07, Vol.74 (7), p.1399-1407

2015

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A critical role for choline kinase-α in the aggressiveness of bladder carcinomas

Oncogene, 2009-07, Vol.28 (26), p.2425-2435

2009

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Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells

Cell death & disease, 2013-11, Vol.4 (11), p.e933-e933

2013

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Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition

Current cancer drug targets, 2012-07, Vol.12 (6), p.617-624

2012

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In vivo antitumor activity of choline kinase inhibitors : A novel target for anticancer drug discovery

Cancer research (Chicago, Ill.), 1999-07, Vol.59 (13), p.3112-3118

1999

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Rho signals to cell growth and apoptosis

Cancer Letters, 2001-04, Vol.165 (1), p.1-10

2001

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Rho proteins induce metastatic properties in vivo

Oncogene, 1997-12, Vol.15 (25), p.3047-3057

1997

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QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?

Current medicinal chemistry, 2003-07, Vol.10 (13), p.1095-1112

2003

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Choline kinase inhibitors as a novel approach for antiproliferative drug design

Oncogene, 1997-11, Vol.15 (19), p.2289-2301

1997

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Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production

Molecular biology of the cell, 2000-12, Vol.11 (12), p.4347-4358

2000

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Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

Oncogene, 2002-06, Vol.21 (27), p.4317-4322

2002

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Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway

Oncogene, 1998-10, Vol.17 (14), p.1855-1869

1998

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Phosphorylcholine : a novel second messenger essential for mitogenic activity of growth factors

Oncogene, 1993-11, Vol.8 (11), p.2959-2968

1993

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Rho GTPases: potential candidates for anticancer therapy

Cancer letters, 2004-04, Vol.206 (2), p.181-191

2004

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A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products

Clinical & translational oncology, 2015-01, Vol.17 (1), p.74-84

2015

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The Ras family of GTPases in cancer cell invasion

Cellular and molecular life sciences : CMLS, 2000, Vol.57 (1), p.65-76

2000

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Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action

Oncogene, 2004-10, Vol.23 (50), p.8247-8259

2004

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Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

Molecular and Cellular Biology, 1990-01, Vol.10 (1), p.333-340

LACAL, J. C

1990

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A ras-Related Protein is Phosphorylated and Translocated by Agonists that Increase cAMP Levels in Human Platelets

Proceedings of the National Academy of Sciences - PNAS, 1989-05, Vol.86 (9), p.3131-3134

1989

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Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells

Oncogene, 1994-05, Vol.9 (5), p.1387-1395

1994

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Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha- ras oncogene

Nature (London), 1987-11, Vol.330 (6145), p.269-272

1987

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Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan α2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro

Folia biologica, 2014, Vol.60 (3), p.95-107

2014

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Tumorigenic activity of rho genes from Aplysia californica

Oncogene, 1993-05, Vol.8 (5), p.1285-1292

1993

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How molecular biology can improve clinical management: the MammaPrint experience

Clinical & translational oncology, 2007-04, Vol.9 (4), p.203-203

Lacal, J C

2007

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Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells

Oncogene, 2003-12, Vol.22 (55), p.8803-8812

2003

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Choline kinase inhibition in rheumatoid arthritis

A critical role for choline kinase-α in the aggressiveness of bladder carcinomas

Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells

Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition

In vivo antitumor activity of choline kinase inhibitors : A novel target for anticancer drug discovery

Rho signals to cell growth and apoptosis

Rho proteins induce metastatic properties in vivo

QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?

Choline kinase inhibitors as a novel approach for antiproliferative drug design

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway

Phosphorylcholine : a novel second messenger essential for mitogenic activity of growth factors

Rho GTPases: potential candidates for anticancer therapy

A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products

The Ras family of GTPases in cancer cell invasion

Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action

Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

A ras-Related Protein is Phosphorylated and Translocated by Agonists that Increase cAMP Levels in Human Platelets

Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha- ras oncogene

Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan α2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro

Tumorigenic activity of rho genes from Aplysia californica

How molecular biology can improve clinical management: the MammaPrint experience

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells

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