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Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis

Pharmacology & therapeutics (Oxford), 2020-04, Vol.208, p.107474, Article 107474

2020

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Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6623-6631

2014

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Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates

The Journal of pharmacology and experimental therapeutics, 2012-10, Vol.343 (1), p.72

2012

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The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

The Journal of clinical investigation, 2024-01, Vol.134 (1), p.1-3

2024

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The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

The Journal of clinical investigation, 2024-01, Vol.134 (1)

2024

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Dibenzazepines and dibenzoxazepines as sodium channel blockers

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (1), p.43-47

2015

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N-Aryl azacycles as novel sodium channel blockers

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (1), p.48-52

2015

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Sodium Channel Blockers

Journal of medicinal chemistry, 2007-05, Vol.50 (11), p.2583-2588

2007

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Solid-phase synthesis of isoindolines via a rhodium-catalyzed [2+2+2] cycloaddition

Tetrahedron letters, 2001-09, Vol.42 (37), p.6495-6497

2001

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DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.783

2004

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Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide - protoxin II

Journal of peptide science, 2012-07, Vol.18 (7), p.442-448

2012

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Display of somatostatin-related peptides in the complementarity determining regions of an antibody light chain

Archives of biochemistry and biophysics, 2005-08, Vol.440 (2), p.148-157

2005

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TRPV1 antagonists: a survey of the patent literature

Expert opinion on therapeutic patents, 2006-07, Vol.16 (7), p.977-996

2006

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Novel, Potent ORL-1 Receptor Agonist Peptides Containing α-Helix-Promoting Conformational Constraints

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5280-5286

2002

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Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5513-5519

2004

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Human B1 and B2 Bradykinin Receptors and Their Agonists Target Caveolae-Related Lipid Rafts to Different Degrees in HEK293 Cells

Biochemistry (Easton), 2002-12, Vol.41 (48), p.14340-14347

2002

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4-(2-Pyridyl)piperazine-1-carboxamides: Potent vanilloid receptor 1 antagonists

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3611-3616

2003

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8-Substituted Analogues of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl- adenine: Highly Potent and Selective PDE4 Inhibitors

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1237-1243

2005

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Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice

British journal of pharmacology, 1996-02, Vol.117 (3), p.552-558

1996

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Solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones

Tetrahedron letters, 2001-06, Vol.42 (25), p.4119-4121

2001

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1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (20), p.5045-5050

2004

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Design and synthesis of novel small molecule N/OFQ receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1347-1351

2004

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A Practical Guide to Combinatorial Chemistry Edited by A. W. Czarnik and S. H. DeWitt. American Chemical Society, Washington, D.C. 1997. xiv + 450 pp. 15.5 × 23.5 cm. ISBN 0-8412-3485. $89.95

Journal of Medicinal Chemistry, 1998-10, Vol.41 (22), p.4424-4425

Kyle, Donald J

1998

Volltextzugriff (PDF)

Combinatorial Chemistry, Synthesis and Application Edited by S. R. Wilson and A. W. Czarnik. John Wiley & Sons, Inc., New York. 1997. ix + 269 pp. 16 × 24 cm. ISBN 0-471-12687. $69.95

Journal of Medicinal Chemistry, 1998-06, Vol.41 (12), p.2172-2173

Kyle, Donald J

1998

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Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis

Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels

Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

Dibenzazepines and dibenzoxazepines as sodium channel blockers

N-Aryl azacycles as novel sodium channel blockers

Sodium Channel Blockers

Solid-phase synthesis of isoindolines via a rhodium-catalyzed [2+2+2] cycloaddition

DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties

Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide - protoxin II

Display of somatostatin-related peptides in the complementarity determining regions of an antibody light chain

TRPV1 antagonists: a survey of the patent literature

Novel, Potent ORL-1 Receptor Agonist Peptides Containing α-Helix-Promoting Conformational Constraints

Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists

Human B1 and B2 Bradykinin Receptors and Their Agonists Target Caveolae-Related Lipid Rafts to Different Degrees in HEK293 Cells

4-(2-Pyridyl)piperazine-1-carboxamides: Potent vanilloid receptor 1 antagonists

8-Substituted Analogues of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl- adenine: Highly Potent and Selective PDE4 Inhibitors

Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice

Solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones

1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor

Design and synthesis of novel small molecule N/OFQ receptor antagonists

A Practical Guide to Combinatorial Chemistry Edited by A. W. Czarnik and S. H. DeWitt. American Chemical Society, Washington, D.C. 1997. xiv + 450 pp. 15.5 × 23.5 cm. ISBN 0-8412-3485. $89.95

Combinatorial Chemistry, Synthesis and Application Edited by S. R. Wilson and A. W. Czarnik. John Wiley & Sons, Inc., New York. 1997. ix + 269 pp. 16 × 24 cm. ISBN 0-471-12687. $69.95

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