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Resources and Methods for Engineering "Designer" Glycan-Binding Proteins

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.380

2021

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The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases

Molecules, 2011-07, Vol.16 (7), p.6092-6115

2011

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Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution

Journal of the American Chemical Society, 2015-05, Vol.137 (17), p.5695-5705

2015

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Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity

Angewandte Chemie (International ed.), 2011-01, Vol.50 (1), p.300-303

International ed. in English, 2011

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Periplasmic de-acylase helps bacteria don their biofilm coat

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (30), p.10904-10905

2014

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A “biphasic glycosyltransferase high-throughput screen” identifies novel anthraquinone glycosides in the diversification of phenolic natural products

The Journal of biological chemistry, 2023-03, Vol.299 (3), p.102931-102931, Article 102931

2023

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Enzymatic Synthesis of a Fluorogenic Reporter Substrate and the Development of a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation

Biochemistry (Easton), 2020-06, Vol.59 (22), p.2100-2110

2020

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Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme

Methods in enzymology, 2017, Vol.597, p.25-53

Kwan, David H

2017

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Divergent directed evolution of a TetR-type repressor towards aromatic molecules

Nucleic acids research, 2023-08, Vol.51 (14), p.7675-7690

2023

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Engineering the enzyme toolbox to tailor glycosylation in small molecule natural products and protein biologics

Protein engineering, design and selection, 2023-01, Vol.36

2023

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Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors

The FEBS journal, 2024-08, Vol.291 (15), p.3481-3498

2024

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Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

Nature structural & molecular biology, 2015-08, Vol.22 (8), p.627-635

2015

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In Vitro Reconstitution of the dTDP‑l‑Daunosamine Biosynthetic Pathway Provides Insights into Anthracycline Glycosylation

ACS chemical biology, 2022-12, Vol.17 (12), p.3331-3340

2022

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A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers

ACS synthetic biology, 2022-04, Vol.11 (4), p.1692-1698

2022

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Enhancement of biological reactions on cell surfaces via macromolecular crowding

Nature communications, 2014-08, Vol.5 (1), p.4683-4683, Article 4683

2014

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Mutagenesis of a Modular Polyketide Synthase Enoylreductase Domain Reveals Insights into Catalysis and Stereospecificity

ACS chemical biology, 2010-09, Vol.5 (9), p.829-838

2010

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A High-Throughput Glycosyltransferase Inhibition Assay for Identifying Molecules Targeting Fucosylation in Cancer Cell-Surface Modification

ACS chemical biology, 2019-04, Vol.14 (4), p.715-724

2019

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Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes

Glycobiology (Oxford), 2015-08, Vol.25 (8), p.806-811

2015

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A fucosyltransferase inhibition assay using image-analysis and digital microfluidics

Biomicrofluidics, 2019-05, Vol.13 (3), p.034106-034106

2019

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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

Organic & biomolecular chemistry, 2011-04, Vol.9 (7), p.2053

2011

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A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis

Analytical biochemistry, 2014-01, Vol.444, p.67-74

2014

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Chemoenzymatic synthesis of 6‐phospho‐cyclophellitol as a novel probe of 6‐phospho‐β‐glucosidases

FEBS letters, 2016-02, Vol.590 (4), p.461-468

2016

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A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis

Chemical communications (Cambridge, England), 2013-10, Vol.49 (86), p.10166-10168

2013

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Berichtigung: Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase

Angewandte Chemie, 2020-06, Vol.132 (23), p.8832-8832

2020

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Toward Efficient Enzymatic Glycan Synthesis: Directed Evolution and Enzyme Engineering

Journal of carbohydrate chemistry, 2011-05, Vol.30 (4-6), p.181-205

2011

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Resources and Methods for Engineering "Designer" Glycan-Binding Proteins

The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution

Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity

Periplasmic de-acylase helps bacteria don their biofilm coat

A “biphasic glycosyltransferase high-throughput screen” identifies novel anthraquinone glycosides in the diversification of phenolic natural products

Enzymatic Synthesis of a Fluorogenic Reporter Substrate and the Development of a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation

Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme

Divergent directed evolution of a TetR-type repressor towards aromatic molecules

Engineering the enzyme toolbox to tailor glycosylation in small molecule natural products and protein biologics

Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

In Vitro Reconstitution of the dTDP‑l‑Daunosamine Biosynthetic Pathway Provides Insights into Anthracycline Glycosylation

A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers

Enhancement of biological reactions on cell surfaces via macromolecular crowding

Mutagenesis of a Modular Polyketide Synthase Enoylreductase Domain Reveals Insights into Catalysis and Stereospecificity

A High-Throughput Glycosyltransferase Inhibition Assay for Identifying Molecules Targeting Fucosylation in Cancer Cell-Surface Modification

Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes

A fucosyltransferase inhibition assay using image-analysis and digital microfluidics

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis

Chemoenzymatic synthesis of 6‐phospho‐cyclophellitol as a novel probe of 6‐phospho‐β‐glucosidases

A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis

Berichtigung: Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase

Toward Efficient Enzymatic Glycan Synthesis: Directed Evolution and Enzyme Engineering

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