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Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6501-6517

2018

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Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

Nature communications, 2017-08, Vol.8 (1), p.262-8, Article 262

2017

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Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Toxicological sciences, 2022-06, Vol.188 (1), p.17-33

2022

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Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

Molecular neurobiology, 2008-12, Vol.38 (3), p.253-269

2008

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Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs

Communications biology, 2022-01, Vol.5 (1), p.52-13, Article 52

2022

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Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment

Molecular & cellular toxicology, 2023-04, Vol.19 (2), p.333-342

2023

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Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine

PloS one, 2016-08, Vol.11 (8), p.e0160807-e0160807

2016

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High-throughput, perfused intestinal tubules for real-time assessment of drug-induced barrier disruption

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S54-S54

2019

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Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid-expressing Müller glia

Journal of comparative neurology (1911), 2010-03, Vol.518 (5), p.636-646

2010

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Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S45-S46

2018

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Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency

Stem cells (Dayton, Ohio), 2018-10, Vol.36 (10), p.1535-1551

2018

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In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

Reproductive toxicology (Elmsford, N.Y.), 2021-10, Vol.105, p.72-90

2021

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Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing

Reproductive toxicology (Elmsford, N.Y.), 2020-12, Vol.98, p.286-298

2020

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Unexpected neurotoxicity in chronic toxicity studies with a HBV viral expression inhibitor

Regulatory toxicology and pharmacology, 2023-06, Vol.141, p.105407-105407, Article 105407

2023

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Organ-on-a-chip technologies that can transform ophthalmic drug discovery and disease modeling

Expert opinion on drug discovery, 2019-01, Vol.14 (1), p.47-57

2019

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Organ-On-A-Chip Technologies for Advanced Blood-Retinal Barrier Models

Journal of ocular pharmacology and therapeutics, 2020-01, Vol.36 (1), p.30

2020

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A Human Three-Dimensional In Vitro Model of Lens Epithelial Cells as a Model to Study Mechanisms of Drug-Induced Posterior Subcapsular Cataracts

Journal of ocular pharmacology and therapeutics, 2020-01, Vol.36 (1), p.56

2020

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Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids

Journal of cellular and molecular medicine, 2023-02, Vol.27 (3), p.435-445

2023

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Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina

Stem cells translational medicine, 2022-03, Vol.11 (2), p.159-177

2022

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Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment

Molecular & cellular toxicology, 2023-04, p.333-342

2023

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Human Retinal Microvasculature‐on‐a‐Chip for Drug Discovery

Advanced healthcare materials, 2020-11, Vol.9 (21), p.e2001531-n/a

2020

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A real-time impedance-based screening assay for drug-induced vascular leakage

Toxicological sciences, 2014-04, Vol.138 (2), p.333-343

2014

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Establishment of rodent and human in vitro systems for the investigation of testicular toxicity

Toxicology letters, 2014-09, Vol.229, p.S134-S134

2014

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Abstract 4681: The use of patient derived malignant effusions as in vitro models for a personalized healthcare-approach in anticancer therapy

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4681-4681

2014

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Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs

Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment

Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine

High-throughput, perfused intestinal tubules for real-time assessment of drug-induced barrier disruption

Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid-expressing Müller glia

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency

In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing

Unexpected neurotoxicity in chronic toxicity studies with a HBV viral expression inhibitor

Organ-on-a-chip technologies that can transform ophthalmic drug discovery and disease modeling

Organ-On-A-Chip Technologies for Advanced Blood-Retinal Barrier Models

A Human Three-Dimensional In Vitro Model of Lens Epithelial Cells as a Model to Study Mechanisms of Drug-Induced Posterior Subcapsular Cataracts

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina

Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment

Human Retinal Microvasculature‐on‐a‐Chip for Drug Discovery

A real-time impedance-based screening assay for drug-induced vascular leakage

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Establishment of rodent and human in vitro systems for the investigation of testicular toxicity

Abstract 4681: The use of patient derived malignant effusions as in vitro models for a personalized healthcare-approach in anticancer therapy

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