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Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases

Cell reports (Cambridge), 2016-02, Vol.14 (4), p.772-781

2016

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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

The Journal of biological chemistry, 2018-08, Vol.293 (35), p.13750-13765

2018

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Challenges in profiling and lead optimization of drug discovery for methyltransferases

Drug discovery today. Technologies, 2015-11, Vol.18, p.62-68

Horiuchi, Kurumi Y.

2015

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Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.10061-10085

2020

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Chemical microarray: a new tool for drug screening and discovery

Drug discovery today, 2006-07, Vol.11 (13), p.661-668

2006

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Assay development for histone methyltransferases

Assay and drug development technologies, 2013-05, Vol.11 (4), p.227

2013

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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

The Journal of biological chemistry, 1998-07, Vol.273 (29), p.18623-18632

1998

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Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases

Assay and drug development technologies, 2015-05, Vol.13 (4), p.221

2015

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295 Feasibility Examination of Prior Administration of Cyclophosphamide in TC Combination

European journal of cancer (1990), 2012-03, Vol.48, p.S128-S128

2012

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Microarrays for the functional analysis of the chemical-kinase interactome

Journal of biomolecular screening, 2006-02, Vol.11 (1), p.48-56

2006

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Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling

Assay and drug development technologies, 2005-04, Vol.3 (2), p.177

2005

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Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays

Methods in molecular biology (Clifton, N.J.), 2009, Vol.572, p.161

2009

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Abstract 170: Development of diacylglycerol kinase assays to facilitate isoform specific inhibitor discovery

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.170-170

2022

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PP009-SUN RESTING ENERGY EXPENDITURE IN PATIENTS UNDERGOING PYLORUS PRESERVING PANCREATODUODENECTOMIES FOR BILE DUCT CANCER OR PANCREATIC TUMORS

Clinical nutrition. Supplements, 2012-09, Vol.7 (1), p.28-28

2012

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Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology

Chemical biology & drug design, 2006-01, Vol.67 (1), p.87-88

2006

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Chemical microarrays: a new tool for discovery enzyme inhibitors

Methods in molecular biology (Clifton, N.J.), 2009, Vol.572, p.149

2009

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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1483-1486

2004

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Fluorescence navigation system with indocyanine green for sentinel lymph nodes biopsy in breast cancer patients

European journal of cancer supplements, 2008, Vol.6 (7), p.169-169

2008

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Mutagenesis and Mechanism-Based Inhibition of Streptococcus pyogenes Glu-tRNAGln Amidotransferase Implicate a Serine-Based Glutaminase Site

Biochemistry (Easton), 2002-05, Vol.41 (20), p.6398-6407

2002

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HotSpot: A Novel Methyltransferase Assay Platform for Drug Screening and Discovery

The FASEB journal, 2010-04, Vol.24 (S1), p.lb61-lb61

2010

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Mechanistic Studies of Reaction Coupling in Glu-tRNAGln Amidotransferase

Biochemistry (Easton), 2001-05, Vol.40 (21), p.6450-6457

2001

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New fluorescence imaging method for sentinel lymph node biopsy in patients with early breast cancer

Journal of clinical oncology, 2011-05, Vol.29 (15_suppl), p.e11578-e11578

2011

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Comparison of T-FEC therapy for HER2-negative breast cancer with TC6 cycle therapy

Journal of clinical oncology, 2011-05, Vol.29 (15_suppl), p.e11513-e11513

2011

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Protective effect of OPC-6535, a superoxide anion production inhibitor, on liver grafts subjected to warm ischemia during porcine liver transplantation

Transplantation proceedings, 2000-03, Vol.32 (2), p.318-321

2000

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Characterization of the Functional Domains on the C-terminal Region of Caldesmon Using Full-length and Mutant Caldesmon Molecules

The Journal of biological chemistry, 1996-01, Vol.271 (4), p.2234-2242

1996

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Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

Challenges in profiling and lead optimization of drug discovery for methyltransferases

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

Chemical microarray: a new tool for drug screening and discovery

Assay development for histone methyltransferases

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases

295 Feasibility Examination of Prior Administration of Cyclophosphamide in TC Combination

Microarrays for the functional analysis of the chemical-kinase interactome

Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling

Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays

Abstract 170: Development of diacylglycerol kinase assays to facilitate isoform specific inhibitor discovery

PP009-SUN RESTING ENERGY EXPENDITURE IN PATIENTS UNDERGOING PYLORUS PRESERVING PANCREATODUODENECTOMIES FOR BILE DUCT CANCER OR PANCREATIC TUMORS

Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology

Chemical microarrays: a new tool for discovery enzyme inhibitors

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

Fluorescence navigation system with indocyanine green for sentinel lymph nodes biopsy in breast cancer patients

Mutagenesis and Mechanism-Based Inhibition of Streptococcus pyogenes Glu-tRNAGln Amidotransferase Implicate a Serine-Based Glutaminase Site

HotSpot: A Novel Methyltransferase Assay Platform for Drug Screening and Discovery

Mechanistic Studies of Reaction Coupling in Glu-tRNAGln Amidotransferase

New fluorescence imaging method for sentinel lymph node biopsy in patients with early breast cancer

Comparison of T-FEC therapy for HER2-negative breast cancer with TC6 cycle therapy

Protective effect of OPC-6535, a superoxide anion production inhibitor, on liver grafts subjected to warm ischemia during porcine liver transplantation

Characterization of the Functional Domains on the C-terminal Region of Caldesmon Using Full-length and Mutant Caldesmon Molecules

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