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White-to-brown metabolic conversion of human adipocytes by JAK inhibition

Nature cell biology, 2015-01, Vol.17 (1), p.57-67

2015

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Machine learning-powered antibiotics phenotypic drug discovery

Scientific reports, 2019-03, Vol.9 (1), p.5013-5013, Article 5013

2019

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11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

The Journal of clinical investigation, 2013-07, Vol.123 (7), p.3051-3060

2013

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How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study

Biochimica et biophysica acta. Biomembranes, 2020-08, Vol.1862 (8), p.183302-183302, Article 183302

2020

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Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter

Nature (London), 2024-07, Vol.631 (8022), p.E17-E17

2024

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6876-6897

2020

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Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

Journal of medicinal chemistry, 2015-10, Vol.58 (20), p.8054-8065

2015

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

Organic & biomolecular chemistry, 2016-01, Vol.14 (25), p.5922-5927

2016

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11 beta -Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP[super]+ and is stimulated by extracellular glucose

Molecular and cellular endocrinology, 2009-03, Vol.301 (1-2), p.137-141

2009

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THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue

Frontiers in endocrinology (Lausanne), 2011, Vol.2, p.89-89

2011

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Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)

The Journal of biological chemistry, 2011-06, Vol.286 (22), p.19501-19510

2011

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Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae

Gene, 1999-09, Vol.237 (1), p.223-234

1999

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Chimia, 2015-01, Vol.69 (7-8), p.407

2015

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Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2)

Hypertension (Dallas, Tex. 1979), 2017-01, Vol.69 (1), p.189-196

2017

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11 beta -Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

The Journal of clinical investigation, 2013-07, Vol.123 (7), p.3051-3051

2013

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Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

The Journal of biological chemistry, 1997-03, Vol.272 (12), p.8026-8031

1997

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11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP + and is stimulated by extracellular glucose

Molecular and cellular endocrinology, 2009-03, Vol.301 (1), p.137-141

2009

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)Electronic supplementary information (ESI) available: Experimental details and characterization data. See DOI: 10.1039/c6ob00848h

2016-06

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An inflammatory micro-environment promotes human adipocyte apoptosis

Molecular and cellular endocrinology, 2011-06, Vol.339 (1-2), p.105-113

2011

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Ras GTPase-Activating Protein: A Substrate and a Potential Binding Protein of the Protein-Tyrosine Kinase p56(lck)

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (8), p.3343

1992

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Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide

Journal of bacteriology, 2000-09, Vol.182 (17), p.4696-4703

2000

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An improved vector system for insertional gene inactivation inspired by the tmRNA-tagging system of S. pneumoniae

Journal of microbiological methods, 2000-10, Vol.42 (2), p.197-201

2000

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The Src homology 2 domain of the protein-tyrosine kinase p56(lck) mediates both intermolecular and intramolecular interactions

Proceedings of the National Academy of Sciences - PNAS, 1993-11, Vol.90 (21), p.10285

1993

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11[Beta]-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

The Journal of clinical investigation, 2013-07, Vol.123 (7), p.3051

2013

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White-to-brown metabolic conversion of human adipocytes by JAK inhibition

Machine learning-powered antibiotics phenotypic drug discovery

A novel antibiotic class targeting the lipopolysaccharide transporter

11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study

Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

11 beta -Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP[super]+ and is stimulated by extracellular glucose

THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue

Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)

Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2)

11 beta -Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP + and is stimulated by extracellular glucose

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)Electronic supplementary information (ESI) available: Experimental details and characterization data. See DOI: 10.1039/c6ob00848h

An inflammatory micro-environment promotes human adipocyte apoptosis

Ras GTPase-Activating Protein: A Substrate and a Potential Binding Protein of the Protein-Tyrosine Kinase p56(lck)

Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide

An improved vector system for insertional gene inactivation inspired by the tmRNA-tagging system of S. pneumoniae

The Src homology 2 domain of the protein-tyrosine kinase p56(lck) mediates both intermolecular and intramolecular interactions

11[Beta]-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

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