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Management of the Heat of Reaction under Continuous Flow Conditions Using In-Line Monitoring Technologies

Organic process research & development, 2020-06, Vol.24 (6), p.1095-1103

2020

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Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2021-11, Vol.52, p.128384-128384, Article 128384

2021

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Investigation into an Unexpected Impurity: A Practical Approach to Process Development for the Addition of Grignard Reagents to Aldehydes Using Continuous Flow Synthesis

Organic process research & development, 2020-03, Vol.24 (3), p.405-414

2020

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Asymmetric [2,3]Sigmatropic Rearrangement of Chiral Allylic Selenimides

Journal of organic chemistry, 1996-05, Vol.61 (9), p.2932-2933

1996

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Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4739-4742

2016

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Synthesis and Antiviral Activity of 7-Benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV Integrase Inhibitors

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2754-2761

2009

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Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6461-6464

2011

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A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate

Organic process research & development, 2007-09, Vol.11 (5), p.899-902

2007

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First synthesis of optically pure selenuranes and stereoselective alkaline hydrolysis. Their application to asymmetric [2,3] sigmatropic rearrangement of allylic selenoxides

Tetrahedron, 1997-09, Vol.53 (36), p.12115-12129

1997

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Asymmetric [2,3] Sigmatropic Rearrangement of Chiral Allylic Selenonium Ylides

Journal of organic chemistry, 1997-07, Vol.62 (14), p.4562-4563

1997

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Chemistry of Novel Compounds Possessing Multifunctional Carbon Atoms. X. Synthetic Studies of Efflcient and Practical Chiral Derivatizing Agents Based on the .ALPHA.-Cyano-.ALPHA.-fluorophenylacetic Acid Structure

Chemical & pharmaceutical bulletin, 1995, Vol.43 (10), p.1668-1673

1995

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Optically Pure Haloselenuranes. First Synthesis and Nucleophilic Substitutions

Journal of organic chemistry, 1994-06, Vol.59 (12), p.3262-3264

1994

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First synthesis and structure of optically pure Te-chiral-alkoxytelluranes

Tetrahedron: asymmetry, 1996-10, Vol.7 (10), p.2797-2800

1996

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Optically Pure Chalcogenuranes : Synthesis and Stereochemical Research of Their Reactions

Journal of Synthetic Organic Chemistry, Japan, 1999/07/01, Vol.57(7), pp.587-597

1999

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Chemistry of Novel Compounds Possessing Multifunctional Carbon Atoms. X. Synthetic Studies of Efficient and Practical Chiral Derivatizing Agents Based on the [alpha]-Cyano-[alpha]-fluorophenylacetic Acid Structure

Chemical & pharmaceutical bulletin, 1995-10, Vol.43 (10), p.1668

1995

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Chemistry of Novel Compounds Possessing Multifunctional Carbon Atoms. X. Synthetic Studies of Efficient and Practical Chiral Derivatizing Agents Based on the α-Cyano-α-fluorophenylacetic Acid Structure

Chemical and Pharmaceutical Bulletin, 1995/10/15, Vol.43(10), pp.1668-1673

1995

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Molecular designing of chiral α-alkoxycarbonylthio aldehydes and their asymmetric Diels-Alder reaction

Phosphorus, sulfur and silicon and the related elements (Print), 1993, Vol.74 (1-4), p.367-368

1993

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Molecular Designing of Chiral α-Alkoxycarbonylthioaldehydes and their Asymmetric Diels-Alder Reaction

Phosphorus, sulfur, and silicon and the related elements, 1993-01, Vol.74 (1-4), p.367-368

1993

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ChemInform Abstract: Optically Pure Chalcogenuranes: Synthesis and Stereochemical Research of Their Reactions

ChemInform, 1999-12, Vol.30 (51), p.no-no

1999

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Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study

Journal of Atherosclerosis and Thrombosis, 2018/06/01, Vol.25(6), pp.490-504

2018

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Single‐pill combination of cilnidipine, an l‐/n‐type calcium channel blocker, and valsartan reduces the day‐by‐day variability of morning home systolic blood pressure in patients with treated hypertension: A sub‐analysis of the HOPE‐combi survey

The journal of clinical hypertension (Greenwich, Conn.), 2021-02, Vol.23 (2), p.392-397

2021

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Lesion distribution after cryoballoon ablation and hotballoon ablation: Late‐gadolinium enhancement magnetic resonance imaging analysis

Journal of cardiovascular electrophysiology, 2019-10, Vol.30 (10), p.1830-1840

2019

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Management of the Heat of Reaction under Continuous Flow Conditions Using In-Line Monitoring Technologies

Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Investigation into an Unexpected Impurity: A Practical Approach to Process Development for the Addition of Grignard Reagents to Aldehydes Using Continuous Flow Synthesis

Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain

Asymmetric [2,3]Sigmatropic Rearrangement of Chiral Allylic Selenimides

Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease

Synthesis and Antiviral Activity of 7-Benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV Integrase Inhibitors

Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors

A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate

First synthesis of optically pure selenuranes and stereoselective alkaline hydrolysis. Their application to asymmetric [2,3] sigmatropic rearrangement of allylic selenoxides

Asymmetric [2,3] Sigmatropic Rearrangement of Chiral Allylic Selenonium Ylides

Chemistry of Novel Compounds Possessing Multifunctional Carbon Atoms. X. Synthetic Studies of Efflcient and Practical Chiral Derivatizing Agents Based on the .ALPHA.-Cyano-.ALPHA.-fluorophenylacetic Acid Structure

Optically Pure Haloselenuranes. First Synthesis and Nucleophilic Substitutions

First synthesis and structure of optically pure Te-chiral-alkoxytelluranes

Optically Pure Chalcogenuranes : Synthesis and Stereochemical Research of Their Reactions

Chemistry of Novel Compounds Possessing Multifunctional Carbon Atoms. X. Synthetic Studies of Efficient and Practical Chiral Derivatizing Agents Based on the [alpha]-Cyano-[alpha]-fluorophenylacetic Acid Structure

Chemistry of Novel Compounds Possessing Multifunctional Carbon Atoms. X. Synthetic Studies of Efficient and Practical Chiral Derivatizing Agents Based on the α-Cyano-α-fluorophenylacetic Acid Structure

Molecular designing of chiral α-alkoxycarbonylthio aldehydes and their asymmetric Diels-Alder reaction

Molecular Designing of Chiral α-Alkoxycarbonylthioaldehydes and their Asymmetric Diels-Alder Reaction

ChemInform Abstract: Optically Pure Chalcogenuranes: Synthesis and Stereochemical Research of Their Reactions

Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study

Single‐pill combination of cilnidipine, an l‐/n‐type calcium channel blocker, and valsartan reduces the day‐by‐day variability of morning home systolic blood pressure in patients with treated hypertension: A sub‐analysis of the HOPE‐combi survey

Lesion distribution after cryoballoon ablation and hotballoon ablation: Late‐gadolinium enhancement magnetic resonance imaging analysis

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