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Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays

SLAS discovery, 2019-02, Vol.24 (2), p.111-120

2019

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The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney

Drug metabolism and disposition, 2024-11, Vol.52 (11), p.1288-1296

2024

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Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.407-412

1998

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Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling

Journal of medicinal chemistry, 1998-02, Vol.41 (5), p.674-681

1998

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Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (19), p.3194-3196

2018

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Ouabain Interactions with the H5-H6 Hairpin of the Na,K-ATPase Reveal a Possible Inhibition Mechanism via the Cation Binding Domain

The Journal of biological chemistry, 1996-06, Vol.271 (24), p.14176-14182

1996

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Na+,K+-ATPase

The Journal of biological chemistry, 1994-08, Vol.269 (31), p.19659-19662

1994

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A Solid Supported Membrane-Based Technology for Electrophysical Screening of B 0 AT1-Modulating Compounds

SLAS discovery, 2021-07, Vol.26 (6), p.783

2021

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A Solid Supported Membrane-Based Technology for Electrophysical Screening of B0AT1-Modulating Compounds

SLAS discovery, 2021-07, Vol.26 (6), p.783-797

2021

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Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.249-254

1998

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Cation and Cardiac Glycoside Binding Sites of the Na,K-ATPase

Annals of the New York Academy of Sciences, 1997-11, Vol.834 (1), p.194-206

1997

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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization

The Journal of pharmacology and experimental therapeutics, 1998-05, Vol.285 (2), p.777

1998

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Glutamic Acid 327 in the Sheep α1 Isoform of Na+,K+-ATPase Stabilizes a K+-induced Conformational Change

The Journal of biological chemistry, 1995-02, Vol.270 (7), p.2993-3000

1995

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Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2797-2802

1998

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Rapid assessment of ligand actions with nicotinic acetylcholine receptors using calcium dynamics and FLIPR

Drug development research, 1998-05, Vol.44 (1), p.14-20

1998

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Novel 2-(2′-furo[3,2- b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (21), p.2703-2708

1997

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The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594

Journal of physiology, Paris, 1998-06, Vol.92 (3), p.221-224

1998

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Critical effects on catalytic function produced by amino acid substitutions at Asp 804 and Asp 808 of the al isoform of Na,K-ATPase

FEBS letters, 1996-07, Vol.389 (2), p.179-185

1996

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Critical effects on catalytic function produced by amino acid substitutions at Asp804 and Asp808 of the al isoform of Na,K‐ATPase

FEBS letters, 1996-07, Vol.389 (2), p.179-185

1996

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Synthesis and structure–activity relationships of 5-substituted pyridine analogues of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (5), p.631-633

2001

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Cation and Cardiac Glycoside Binding Sites of the Na,K‐ATPasea

Annals of the New York Academy of Sciences, 1997-11, Vol.834 (1), p.194-206

1997

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Asp804 and Asp808 in the Transmembrane Domain of the Na,K-ATPase α Subunit Are Cation Coordinating Residues

The Journal of biological chemistry, 1996-11, Vol.271 (47), p.29682-29687

1996

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Synthesis and structure–activity relationships of 5-substituted pyridine analogues of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543 : A potent nicotinic receptor ligand

Bioorganic & medicinal chemistry letters, 2001, Vol.11 (5), p.631-633

2001

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Inactivation and phosphorylation of sarcoplasmic reticulum Ca 2+-ATPase by Mg · ATP analogues Rh(III)-ATP and Co(III)-ATP

Archives of biochemistry and biophysics, 1992, Vol.295 (1), p.188-197

1992

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Amino Acid Replacement of Asp369 in the Sheep α1 Isoform Eliminates ATP and Phosphate Stimulation of [3]H Ouabain Binding to the Na+,K+-ATPase without Altering the Cation Binding Properties of the Enzyme

The Journal of biological chemistry, 1995-07, Vol.270 (27), p.16206-16212

1995

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Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays

The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney

Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling

Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators

Ouabain Interactions with the H5-H6 Hairpin of the Na,K-ATPase Reveal a Possible Inhibition Mechanism via the Cation Binding Domain

Na+,K+-ATPase

A Solid Supported Membrane-Based Technology for Electrophysical Screening of B 0 AT1-Modulating Compounds

A Solid Supported Membrane-Based Technology for Electrophysical Screening of B0AT1-Modulating Compounds

Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Cation and Cardiac Glycoside Binding Sites of the Na,K-ATPase

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization

Glutamic Acid 327 in the Sheep α1 Isoform of Na+,K+-ATPase Stabilizes a K+-induced Conformational Change

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Rapid assessment of ligand actions with nicotinic acetylcholine receptors using calcium dynamics and FLIPR

Novel 2-(2′-furo[3,2- b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands

The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594

Critical effects on catalytic function produced by amino acid substitutions at Asp 804 and Asp 808 of the al isoform of Na,K-ATPase

Critical effects on catalytic function produced by amino acid substitutions at Asp804 and Asp808 of the al isoform of Na,K‐ATPase

Synthesis and structure–activity relationships of 5-substituted pyridine analogues of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543

Cation and Cardiac Glycoside Binding Sites of the Na,K‐ATPasea

Asp804 and Asp808 in the Transmembrane Domain of the Na,K-ATPase α Subunit Are Cation Coordinating Residues

Synthesis and structure–activity relationships of 5-substituted pyridine analogues of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543 : A potent nicotinic receptor ligand

Inactivation and phosphorylation of sarcoplasmic reticulum Ca 2+-ATPase by Mg · ATP analogues Rh(III)-ATP and Co(III)-ATP

Amino Acid Replacement of Asp369 in the Sheep α1 Isoform Eliminates ATP and Phosphate Stimulation of [3]H Ouabain Binding to the Na+,K+-ATPase without Altering the Cation Binding Properties of the Enzyme

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