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CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

Leukemia, 2014-01, Vol.28 (1), p.155-165

2014

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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Genes & development, 2005-02, Vol.19 (4), p.489-501

2005

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Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

Science translational medicine, 2012-08, Vol.4 (148), p.148ra117

2012

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Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

Science (American Association for the Advancement of Science), 2004-09, Vol.305 (5689), p.1466-1470

2004

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H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

Cancer cell, 2008-11, Vol.14 (5), p.355-368

2008

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Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice

Leukemia, 2016-01, Vol.30 (1), p.0-0

2016

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

Cancer cell, 2005-02, Vol.7 (2), p.129-141

2005

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Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

Cancer cell, 2004-03, Vol.5 (3), p.221-230

2004

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A Small-Molecule Antagonist of CXCR4 Inhibits Intracranial Growth of Primary Brain Tumors

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13513-13518

2003

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Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo

Fertility and sterility, 2011-10, Vol.96 (4), p.1021-1028.e1

2011

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Proteomic and Genetic Approaches Identify Syk as an AML Target

Cancer cell, 2009-10, Vol.16 (4), p.281-294

2009

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Suppression of tumor growth through disruption of hypoxia-inducible transcription

Nature medicine, 2000-12, Vol.6 (12), p.1335-1340

2000

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Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

Science (American Association for the Advancement of Science), 2003-04, Vol.300 (5617), p.342-344

2003

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Cancer cell, 2004-07, Vol.6 (1), p.33-43

2004

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Antimyeloma activity of heat shock protein-90 inhibition

Blood, 2006-02, Vol.107 (3), p.1092-1100

2006

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MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment

Leukemia, 2008-01, Vol.22 (1), p.66-77

2008

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Structural Basis for Recruitment of CBP/p300 by Hypoxia-Inducible Factor-1α

Proceedings of the National Academy of Sciences - PNAS, 2002-04, Vol.99 (8), p.5367-5372

2002

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Distinct Roles for CREB-Binding Protein and p300 in Hematopoietic Stem Cell Self-Renewal

Proceedings of the National Academy of Sciences - PNAS, 2002-11, Vol.99 (23), p.14789-14794

2002

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Inhibition of FLT3 in MLL: Validation of a therapeutic target identified by gene expression based classification

Cancer cell, 2003-02, Vol.3 (2), p.173-183

2003

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Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies

Cancer research (Chicago, Ill.), 2005-12, Vol.65 (24), p.11392-11399

2005

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Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2

Nature structural & molecular biology, 2003-07, Vol.10 (7), p.504-512

2003

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Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect

Neurosurgery, 2006-02, Vol.58 (2), p.365-372

2006

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Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

Genes & development, 2000-02, Vol.14 (3), p.272-277

2000

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Role of T-bet in commitment of T(H)1 cells before IL- 12--dependent selection

Science (American Association for the Advancement of Science), 2001-06, Vol.292 (5523), p.1907-1910

2001

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CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

A Small-Molecule Antagonist of CXCR4 Inhibits Intracranial Growth of Primary Brain Tumors

Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo

Proteomic and Genetic Approaches Identify Syk as an AML Target

Suppression of tumor growth through disruption of hypoxia-inducible transcription

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Antimyeloma activity of heat shock protein-90 inhibition

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

Structural Basis for Recruitment of CBP/p300 by Hypoxia-Inducible Factor-1α

Distinct Roles for CREB-Binding Protein and p300 in Hematopoietic Stem Cell Self-Renewal

Inhibition of FLT3 in MLL: Validation of a therapeutic target identified by gene expression based classification

Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies

Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2

Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

Role of T-bet in commitment of T(H)1 cells before IL- 12--dependent selection

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