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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8306-8325

2016

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7669-7683

2019

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A Mechanism for Ion Selectivity in Potassium Channels: Computational Studies of Cation-π Interactions

Science (American Association for the Advancement of Science), 1993-09, Vol.261 (5129), p.1708-1710

1993

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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4961-4974

2002

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Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Journal of medicinal chemistry, 2004-10, Vol.47 (22), p.5467-5481

2004

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Molecular recognition in aqueous media. New binding studies provide further insights into the cation-.pi. interaction and related phenomena

Journal of the American Chemical Society, 1993-11, Vol.115 (22), p.9907-9919

1993

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Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361

JNCI : Journal of the National Cancer Institute, 2004-01, Vol.96 (1), p.56-67

2004

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Interaction of formaldehyde with water

Journal of physical chemistry (1952), 1989-06, Vol.93 (11), p.4478-4486

1989

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)‑5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)‑one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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Hydration of polar organic molecules: the interaction of acetonitrile with water

Journal of physical chemistry (1952), 1987-06, Vol.91 (12), p.3449-3452

1987

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Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Journal of medicinal chemistry, 2004-10, Vol.47 (22), p.5467-5481

2004

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Parametrization of molecular mechanics calculations for the accurate description of hydrogen-bonding interactions

Journal of physical chemistry (1952), 1990-08, Vol.94 (17), p.6619-6626

1990

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Interaction of carbon dioxide and water investigated by a combination of ab initio and SOLDRI-MM2 techniques

Journal of physical chemistry (1952), 1989-11, Vol.93 (22), p.7640-7644

1989

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Do nitromethane and malononitrile form C-H•••O hydrogen bonds? Implications for molecular recognition by crown ethers

Journal of the Chemical Society. Chemical communications, 1988 (9), p.621-622

1988

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Attaining Economy in the Pharmacy through Non-Sterile Manufacture

American journal of health-system pharmacy, 1947-12, Vol.4 (6_Suppl), p.S24-S25

Kumpf, Robert A.

1947

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The root cap: a short story of life and death

Journal of experimental botany, 2015-09, Vol.66 (19), p.5651-5662

2015

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Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6433)

2019

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Floral organ abscission peptide IDA and its HAE/HSL2 receptors control cell separation during lateral root emergence

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (13), p.5235-5240

2013

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A Spatiotemporal DNA Endoploidy Map of the Arabidopsis Root Reveals Roles for the Endocycle in Root Development and Stress Adaptation

The Plant cell, 2018-10, Vol.30 (10), p.2330-2351

2018

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A quiescent path to plant longevity

Trends in cell biology, 2014-08, Vol.24 (8), p.443-448

2014

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SHORT-ROOT Deficiency Alleviates the Cell Death Phenotype of the Arabidopsis catalase2 Mutant under Photorespiration-Promoting Conditions

The Plant cell, 2016-08, Vol.28 (8), p.1844-1859

2016

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Structure–function study of a Ca2+-independent metacaspase involved in lateral root emergence

Plant biology (Stuttgart, Germany), 2023-05, Vol.120 (22), p.1-e2303480120

2023

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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

A Mechanism for Ion Selectivity in Potassium Channels: Computational Studies of Cation-π Interactions

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure

Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Molecular recognition in aqueous media. New binding studies provide further insights into the cation-.pi. interaction and related phenomena

Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361

Interaction of formaldehyde with water

Hydration of polar organic molecules: the interaction of acetonitrile with water

Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Parametrization of molecular mechanics calculations for the accurate description of hydrogen-bonding interactions

Interaction of carbon dioxide and water investigated by a combination of ab initio and SOLDRI-MM2 techniques

Do nitromethane and malononitrile form C-H•••O hydrogen bonds? Implications for molecular recognition by crown ethers

Attaining Economy in the Pharmacy through Non-Sterile Manufacture

The root cap: a short story of life and death

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides

Floral organ abscission peptide IDA and its HAE/HSL2 receptors control cell separation during lateral root emergence

A Spatiotemporal DNA Endoploidy Map of the Arabidopsis Root Reveals Roles for the Endocycle in Root Development and Stress Adaptation

A quiescent path to plant longevity

SHORT-ROOT Deficiency Alleviates the Cell Death Phenotype of the Arabidopsis catalase2 Mutant under Photorespiration-Promoting Conditions

Structure–function study of a Ca2+-independent metacaspase involved in lateral root emergence

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