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Direct catalytic asymmetric aldol reactions of aldehydes

Chemical communications (Cambridge, England), 2002-03 (6), p.620-621

2002

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Memapsin 2 (beta-secretase) inhibitors: drug development

Current Alzheimer research, 2008-04, Vol.5 (2), p.121

2008

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Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease

Current topics in medicinal chemistry, 2005-12, Vol.5 (16), p.1609

2005

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Applications of Baylis–Hillman chemistry: enantioselective synthesis of (−)-methyl 3-aryl-2-methylene-3-(prop-2-yn-1-yloxy)propanoates via chiral leaving group strategy

Tetrahedron, 2001-09, Vol.57 (38), p.8167-8172

2001

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Direct Organo-Catalytic Asymmetric α-Amination of Aldehydes-A Simple Approach to Optically Active α-Amino Aldehydes, α-Amino Alcohols, and α-Amino Acids

Angewandte Chemie (International ed.), 2002-05, Vol.41 (10), p.1790-1793

2002

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An expedient, facile and simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles from the Baylis-Hillman bromides in aqueous media

Nature protocols, 2007-11, Vol.2 (11), p.2665-2676

2007

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Direct l-Proline-Catalyzed Asymmetric α-Amination of Ketones

Journal of the American Chemical Society, 2002-06, Vol.124 (22), p.6254-6255

2002

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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (15)

2018

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Abstract 2643: Discovery and characterization of a selective TrkA inhibitor for the treatment of TrkA-driven cancers

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2643-2643

2016

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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (15), p.2605-2610

2018

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Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11)

2017

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Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2432-2438

2017

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Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1031-1036

2008

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Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P2 -P3-Ligands

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2399-2407

2007

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Catalytic Highly Enantioselective Direct Amination of 1,3-Diketones

Synthesis (Stuttgart), 2005, Vol.2005 (6), p.957-960

2005

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Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance

ChemMedChem, 2006-09, Vol.1 (9), p.939-950

2006

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The Baylis–Hillman chemistry in aqueous media: a convenient synthesis of 2-methylenealkanoates and alkanenitriles

Tetrahedron letters, 2001-01, Vol.42 (3), p.477-479

2001

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Design, Synthesis and X-ray Structure of Protein−Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors

Journal of the American Chemical Society, 2006-04, Vol.128 (16), p.5310-5311

2006

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The Baylis−Hillman Reaction: One-Pot Facile Synthesis of 2,4-Functionalized 1,4-Pentadienes

Journal of organic chemistry, 2002-10, Vol.67 (20), p.7135-7137

2002

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Baylis–Hillman chemistry: a novel synthesis of functionalized 1,4-pentadienes

Tetrahedron letters, 2001-01, Vol.42 (1), p.85-87

2001

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Applications of Baylis–Hillman chemistry: one-pot convenient synthesis of functionalized (1 H)-quinol-2-ones and quinolines

Tetrahedron, 2002-05, Vol.58 (19), p.3693-3697

2002

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A Facile One-Pot Conversion of Acetates of the Baylis−Hillman Adducts to [E]-α-Methylcinnamic Acids

Journal of organic chemistry, 1999-02, Vol.64 (4), p.1197-1200

1999

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Catalytic Highly Enantioselective Direct Amination of 1,3-Diketones

Synthesis (Stuttgart), 2005-04, Vol.2005 (6), p.957-960

2005

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Applications of the Baylis-Hillman Adducts in Organic Synthesis: A Facile Synthesis of [E]-α-Cyanocinnamyl Alcohols and [E]-α-Cyanocinnamic Aldehydes

Synlett, 1999-10, Vol.1999 (10), p.1630-1632

1999

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Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P 2 - P 3 -Ligands

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2399-2407

2007

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Direct catalytic asymmetric aldol reactions of aldehydes

Memapsin 2 (beta-secretase) inhibitors: drug development

Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease

Applications of Baylis–Hillman chemistry: enantioselective synthesis of (−)-methyl 3-aryl-2-methylene-3-(prop-2-yn-1-yloxy)propanoates via chiral leaving group strategy

Direct Organo-Catalytic Asymmetric α-Amination of Aldehydes-A Simple Approach to Optically Active α-Amino Aldehydes, α-Amino Alcohols, and α-Amino Acids

An expedient, facile and simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles from the Baylis-Hillman bromides in aqueous media

Direct l-Proline-Catalyzed Asymmetric α-Amination of Ketones

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Abstract 2643: Discovery and characterization of a selective TrkA inhibitor for the treatment of TrkA-driven cancers

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P2 -P3-Ligands

Catalytic Highly Enantioselective Direct Amination of 1,3-Diketones

Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance

The Baylis–Hillman chemistry in aqueous media: a convenient synthesis of 2-methylenealkanoates and alkanenitriles

Design, Synthesis and X-ray Structure of Protein−Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors

The Baylis−Hillman Reaction: One-Pot Facile Synthesis of 2,4-Functionalized 1,4-Pentadienes

Baylis–Hillman chemistry: a novel synthesis of functionalized 1,4-pentadienes

Applications of Baylis–Hillman chemistry: one-pot convenient synthesis of functionalized (1 H)-quinol-2-ones and quinolines

A Facile One-Pot Conversion of Acetates of the Baylis−Hillman Adducts to [E]-α-Methylcinnamic Acids

Catalytic Highly Enantioselective Direct Amination of 1,3-Diketones

Applications of the Baylis-Hillman Adducts in Organic Synthesis: A Facile Synthesis of [E]-α-Cyanocinnamyl Alcohols and [E]-α-Cyanocinnamic Aldehydes

Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P 2 - P 3 -Ligands

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