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Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.569-573

2013

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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Journal of virology, 2021-08, Vol.95 (18), p.e0057421-e0057421

2021

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Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506

Bioorganic & medicinal chemistry letters, 2023-10, Vol.94, p.129456-129456, Article 129456

2023

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Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

Antiviral research, 2022-01, Vol.197, p.105211-105211, Article 105211

2022

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The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly

RSC medicinal chemistry, 2022-03, Vol.13 (3), p.343-349

2022

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Synthesis and Biological Evaluation of Pyrazolo[1,5‑a]pyrimidine Compounds as Potent and Selective Pim‑1 Inhibitors

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.63-67

2015

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Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2

ACS infectious diseases, 2024-05, Vol.10 (5), p.1780-1792

2024

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Discovery of novel quinolinone adenosine A2B antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7414-7420

2010

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Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6027-6031

2009

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Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2724-2728

2006

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Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1713-1716

2004

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Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1717-1720

2004

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Preclinical anti-tumor activity of small-molecule oral PD-L1 checkpoint inhibitors

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.e14558-e14558

2022

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Preclinical activity of small-molecule oral PD-L1 checkpoint inhibitors capable of reinvigorating T cell responses from chronic hepatitis B patients

Journal of hepatology, 2022-07, Vol.77, p.S848

2022

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Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

Antimicrobial agents and chemotherapy, 2018-06, Vol.62 (6)

2018

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2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.545-548

2004

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Photochemical synthesis of medium-ring azalactams from N-(aminoalkyl)-2-stilbenecarboxamides

Journal of photochemistry and photobiology. A, Chemistry., 1998-01, Vol.112 (2), p.159-164

1998

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Aberrant SRN1 Reaction of 4-Aminophenol with α,p-Dinitrocumene: EPR Observation of Intermediates

Organic letters, 2000-03, Vol.2 (6), p.827-829

2000

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Microwave-Assisted, One-Pot Synthesis of 5-Thia-4 b ,10-diaza-indeno[2,1- a ]-indene-5,5-dioxide and 10 H -11-Thia-5,10 a -diaza-benzo[ b ]fluorene-11,11-dioxide

Synthetic communications, 2009-09, Vol.39 (20), p.3607-3610

2009

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Microwave-Assisted, One-Pot Synthesis of 5-Thia-4b,10-diaza-indeno[2,1-a]-indene-5,5-dioxide and 10H-11-Thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide

Synthetic communications, 2009-01, Vol.39 (20), p.3607-3610

2009

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Discovery of novel quinolinone adenosine A sub(2B) antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7414-7420

2010

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Discovery of novel quinolinone adenosine A 2B antagonists

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (24), p.7414-7420

2010

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Small molecule biaryl FSH receptor agonists. Part 1

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1713-1716

2004

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Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly

Synthesis and Biological Evaluation of Pyrazolo[1,5‑a]pyrimidine Compounds as Potent and Selective Pim‑1 Inhibitors

Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2

Discovery of novel quinolinone adenosine A2B antagonists

Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis

Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis

Preclinical anti-tumor activity of small-molecule oral PD-L1 checkpoint inhibitors

Preclinical activity of small-molecule oral PD-L1 checkpoint inhibitors capable of reinvigorating T cell responses from chronic hepatitis B patients

Safety, tolerability, pharmacokinetics (PK), and antiviral activity of the 3rd generation capsid inhibitor AB-836 in healthy subjects (HS) and subjects with chronic hepatitis B (CHB)

Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors

Photochemical synthesis of medium-ring azalactams from N-(aminoalkyl)-2-stilbenecarboxamides

Aberrant SRN1 Reaction of 4-Aminophenol with α,p-Dinitrocumene: EPR Observation of Intermediates

Microwave-Assisted, One-Pot Synthesis of 5-Thia-4 b ,10-diaza-indeno[2,1- a ]-indene-5,5-dioxide and 10 H -11-Thia-5,10 a -diaza-benzo[ b ]fluorene-11,11-dioxide

Microwave-Assisted, One-Pot Synthesis of 5-Thia-4b,10-diaza-indeno[2,1-a]-indene-5,5-dioxide and 10H-11-Thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide

Discovery of novel quinolinone adenosine A sub(2B) antagonists

Discovery of novel quinolinone adenosine A 2B antagonists

Small molecule biaryl FSH receptor agonists. Part 1

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