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Artificial intelligence and the analysis of cryo-EM data provide structural insight into the molecular mechanisms underlying LN-lamininopathies

Scientific reports, 2023-10, Vol.13 (1), p.17825-17825, Article 17825

Kulczyk, Arkadiusz W.

2023

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Cryo-Electron Microscopy Studies of Biomolecular Structure and Dynamics

Micromachines (Basel), 2024-08, Vol.15 (9), p.1092

Kulczyk, Arkadiusz W

2024

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Exploring the Structural Variability of Dynamic Biological Complexes by Single-Particle Cryo-Electron Microscopy

Micromachines (Basel), 2022-12, Vol.14 (1), p.118

2022

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Novel Artificial Intelligence-Based Approaches for Ab Initio Structure Determination and Atomic Model Building for Cryo-Electron Microscopy

Micromachines (Basel), 2023-08, Vol.14 (9), p.1674

2023

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Simultaneous Real-Time Imaging of Leading and Lagging Strand Synthesis Reveals the Coordination Dynamics of Single Replisomes

Molecular cell, 2016-12, Vol.64 (6), p.1035-1047

2016

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Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis

Nature communications, 2024-05, Vol.15 (1), p.3791-3791, Article 3791

2024

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Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (9), p.3584-3589

2011

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Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.4073-4078

2014

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Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis

Scientific reports, 2016-11, Vol.6 (1), p.37708-37708, Article 37708

2016

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You cannot oxidize what you cannot reach: Oxidative susceptibility of buried methionine residues

The Journal of biological chemistry, 2022-05, Vol.298 (5), p.101973, Article 101973

2022

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Polymerizing laminins in development, health, and disease

The Journal of biological chemistry, 2024-07, Vol.300 (7), p.107429, Article 107429

2024

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Molecular interactions in the priming complex of bacteriophage T7

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (24), p.9408-9413

2012

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Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies

Nature communications, 2023-01, Vol.14 (1), p.317-317

2023

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Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15033-15038

2010

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Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies

Nature communications, 2023-01, Vol.14 (1), p.317, Article 317

2023

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A Robust Single-Particle Cryo-Electron Microscopy (cryo-EM) Processing Workflow with cryoSPARC, RELION, and Scipion

Journal of visualized experiments, 2022-01 (179)

2022

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Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction

The Journal of biological chemistry, 2023-01, Vol.299 (1), p.102795, Article 102795

2023

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Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.E1848-E1856

2017

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A crystal structure of coil 1B of vimentin in the filamentous form provides a model of a high‐order assembly of a vimentin filament

The FEBS journal, 2018-08, Vol.285 (15), p.2888-2899

2018

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Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk

Molecular microbiology, 2008-01, Vol.67 (2), p.448-457

2008

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Electron microscopy holdings of the Protein Data Bank: the impact of the resolution revolution, new validation tools, and implications for the future

Biophysical reviews, 2022-12, Vol.14 (6), p.1281-1301

2022

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An Interaction between DNA Polymerase and Helicase Is Essential for the High Processivity of the Bacteriophage T7 Replisome

The Journal of biological chemistry, 2012-11, Vol.287 (46), p.39050-39060

2012

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Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication

The Journal of biological chemistry, 2012-10, Vol.287 (41), p.34273-34287

2012

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Coupling dTTP Hydrolysis with DNA Unwinding by the DNA Helicase of Bacteriophage T7

The Journal of biological chemistry, 2011-09, Vol.286 (39), p.34468-34478

2011

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Characterization of a Nucleotide Kinase Encoded by Bacteriophage T7

The Journal of biological chemistry, 2012-08, Vol.287 (35), p.29468-29478

2012

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Artificial intelligence and the analysis of cryo-EM data provide structural insight into the molecular mechanisms underlying LN-lamininopathies

Cryo-Electron Microscopy Studies of Biomolecular Structure and Dynamics

Exploring the Structural Variability of Dynamic Biological Complexes by Single-Particle Cryo-Electron Microscopy

Novel Artificial Intelligence-Based Approaches for Ab Initio Structure Determination and Atomic Model Building for Cryo-Electron Microscopy

Simultaneous Real-Time Imaging of Leading and Lagging Strand Synthesis Reveals the Coordination Dynamics of Single Replisomes

Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis

Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange

Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis

You cannot oxidize what you cannot reach: Oxidative susceptibility of buried methionine residues

Polymerizing laminins in development, health, and disease

Molecular interactions in the priming complex of bacteriophage T7

Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies

Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin

Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies

A Robust Single-Particle Cryo-Electron Microscopy (cryo-EM) Processing Workflow with cryoSPARC, RELION, and Scipion

Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction

Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis

A crystal structure of coil 1B of vimentin in the filamentous form provides a model of a high‐order assembly of a vimentin filament

Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk

Electron microscopy holdings of the Protein Data Bank: the impact of the resolution revolution, new validation tools, and implications for the future

An Interaction between DNA Polymerase and Helicase Is Essential for the High Processivity of the Bacteriophage T7 Replisome

Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication

Coupling dTTP Hydrolysis with DNA Unwinding by the DNA Helicase of Bacteriophage T7

Characterization of a Nucleotide Kinase Encoded by Bacteriophage T7

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