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The G protein preference of orexin receptors is currently an unresolved issue

Nature communications, 2023-06, Vol.14 (1), p.3162-3162, Article 3162

Kukkonen, Jyrki P

2023

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Physiology of the orexinergic/hypocretinergic system: a revisit in 2012

American Journal of Physiology: Cell Physiology, 2013-01, Vol.304 (1), p.C2-C32

Kukkonen, Jyrki P

2013

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OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells

Cellular signalling, 2016-02, Vol.28 (2), p.51-60

Kukkonen, Jyrki P.

2016

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Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Scientific reports, 2024-04, Vol.14 (1), p.7690-7690, Article 7690

2024

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OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release

Molecular pharmacology, 2012-08, Vol.82 (2), p.156-167

2012

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Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity

PloS one, 2017-06, Vol.12 (6), p.e0178526-e0178526

2017

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Measurement of orexin levels is currently an uncertain business

Sleep medicine, 2023-07, Vol.107, p.308-308

Kukkonen, Jyrki P.

2023

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Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells

Biomedicine & pharmacotherapy, 2020-11, Vol.131, p.110788-110788, Article 110788

2020

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Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8263-8275

2016

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Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Pharmaceuticals (Basel, Switzerland), 2017-10, Vol.10 (4), p.79

2017

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OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Frontiers in neuroscience, 2014-05, Vol.8, p.57-57

2014

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Allosteric interactions via the orthosteric ligand binding sites in a constitutive G-protein-coupled receptor homodimer

Pharmacological research, 2021-04, Vol.166, p.105116-105116, Article 105116

Kukkonen, Jyrki P.

2021

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Corrigendum to “Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells” [Biomed. Pharmacother. 131 (2020) 110788]

Biomedicine & pharmacotherapy, 2021-01, Vol.133, p.111019-111019, Article 111019

2021

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Structure–Activity Relationships of 1‐Benzoylazulenes at the OX1 and OX2 Orexin Receptors

ChemMedChem, 2019-05, Vol.14 (9), p.965-981

2019

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G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells

Biochemical and biophysical research communications, 2016-08, Vol.476 (4), p.379-385

Kukkonen, Jyrki P.

2016

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CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDα1

Plant physiology (Bethesda), 2019-08, Vol.180 (4), p.2004-2021

2019

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G-protein inhibition profile of the reported Gq/11 inhibitor UBO-QIC

Biochemical and biophysical research communications, 2016-01, Vol.469 (1), p.101-107

Kukkonen, Jyrki P.

2016

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Functions of the orexinergic/hypocretinergic system

American Journal of Physiology: Cell Physiology, 2002-12, Vol.283 (6), p.C1567-C1591

2002

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Recent progress in orexin/hypocretin physiology and pharmacology

Biomolecular concepts, 2012-10, Vol.3 (5), p.447-463

Kukkonen, Jyrki P.

2012

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OX1 Orexin Receptors Couple to Adenylyl Cyclase Regulation via Multiple Mechanisms

The Journal of biological chemistry, 2005-02, Vol.280 (8), p.6570-6579

2005

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Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery

British journal of pharmacology, 2014-12, Vol.171 (24), p.5816-5828

2014

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Agonist ligand discrimination by the two orexin receptors depends on the expression system

Neuroscience letters, 2011-04, Vol.494 (1), p.57-60

2011

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Lipid signaling cascades of orexin/hypocretin receptors

Biochimie, 2014-01, Vol.96, p.158-165

Kukkonen, Jyrki P.

2014

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Orexin/Hypocretin Signaling

Behavioral Neuroscience of Orexin/Hypocretin, 2017, Vol.33, p.17-50

2017

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G-protein-coupled OX1 Orexin/hcrtr-1 Hypocretin Receptors Induce Caspase-dependent and -independent Cell Death through p38 Mitogen-/Stress-activated Protein Kinase

The Journal of biological chemistry, 2006-01, Vol.281 (2), p.834-842

2006

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The G protein preference of orexin receptors is currently an unresolved issue

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012

OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release

Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity

Measurement of orexin levels is currently an uncertain business

Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells

Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Allosteric interactions via the orthosteric ligand binding sites in a constitutive G-protein-coupled receptor homodimer

Corrigendum to “Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells” [Biomed. Pharmacother. 131 (2020) 110788]

Structure–Activity Relationships of 1‐Benzoylazulenes at the OX1 and OX2 Orexin Receptors

G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells

CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDα1

G-protein inhibition profile of the reported Gq/11 inhibitor UBO-QIC

Functions of the orexinergic/hypocretinergic system

Recent progress in orexin/hypocretin physiology and pharmacology

OX1 Orexin Receptors Couple to Adenylyl Cyclase Regulation via Multiple Mechanisms

Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery

Agonist ligand discrimination by the two orexin receptors depends on the expression system

Lipid signaling cascades of orexin/hypocretin receptors

Orexin/Hypocretin Signaling

G-protein-coupled OX1 Orexin/hcrtr-1 Hypocretin Receptors Induce Caspase-dependent and -independent Cell Death through p38 Mitogen-/Stress-activated Protein Kinase

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