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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Science (American Association for the Advancement of Science), 2020-09, Vol.369 (6508), p.1261-1265

2020

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Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV‑2 Neutralization

The journal of physical chemistry. B, 2023-03, Vol.127 (9), p.1995-2001

2023

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Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

Nature chemical biology, 2022-03, Vol.18 (3), p.342-351

2022

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Computationally Designed ACE2 Decoy Receptor Binds SARS-CoV‑2 Spike (S) Protein with Tight Nanomolar Affinity

Journal of chemical information and modeling, 2021-09, Vol.61 (9), p.4656-4669

2021

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An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2

EMBO molecular medicine, 2022-11, Vol.14 (11), p.e16109-n/a

2022

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An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

Science advances, 2021-02, Vol.7 (8)

2021

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Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Molecular therapy. Methods & clinical development, 2024-09, Vol.32 (3), p.101301, Article 101301

2024

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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization

Biochemistry (Easton), 2009-06, Vol.48 (24), p.5518-5531

2009

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Introduction of a polar core into the de novo designed protein Top7

Protein science, 2016-07, Vol.25 (7), p.1299-1307

2016

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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

Biochemistry (Easton), 2009-06, Vol.48 (24), p.5510-5517

2009

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An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

Biochemistry (Easton), 2009-08, Vol.48 (33), p.8006-8013

2009

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Sensitivity estimation for calculated phase equilibria

Journal of materials research, 2021-01, Vol.36 (1), p.140-150

2021

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542 oral CLINICAL IMPLEMENTATION OF A PROTOCOL FOR PATIENTS CARRYING A PACEMAKER OR ICD RECEIVING RADIOTHERAPY

Radiotherapy and oncology, 2011, Vol.99, p.S221-S221

2011

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Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: d-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

Biochemistry (Easton), 2008-09, Vol.47 (36), p.9608-9617

2008

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Sa1729 Protein Kinase D1 Is an Upstream Kinase for Class II Histone Deacetylases (HDAC) 4, 5 and 7 in Intestinal Epithelial Cells

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-293-S-293

2013

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299 Identification of Protein Kinase D1 as an Upstream Kinase of Class II Histone Deacetylases (HDAC) 4 and 7 in Intestinal Epithelial Cells

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-67-S-67

2012

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Mo1648 Protein Kinase D1 Mediates Mitogenic Signaling in Intestinal Epithelial Cells

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-649-S-649

2012

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649 Synergistic Inhibition of Pancreatic Cancer Cell Proliferation by Metformin and Rapamycin: Identification of a Novel Combinatorial Drug Strategy

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-129-S-129

2012

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Protein Kinase D1 Mediates Mitogenic Signaling in Intestinal Epithelial IEC-6 and IEC-18 Cells

Gastroenterology (New York, N.Y. 1943), 2011, Vol.140 (5), p.S-632-S-632

2011

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Transgenic Protein Kinase D1 Stimulates the Rate of Epithelial Cell Proliferation in Intestinal Crypts

Gastroenterology (New York, N.Y. 1943), 2011, Vol.140 (5), p.S-473-S-473

2011

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Mo1644 Protein Kinase D1 (Pkd1) Mediates β-Catenin Signaling and Phosphorylation at Ser552 in Intestinal Epithelial Cells

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-648-S-648

2012

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1062 The Direct AMPK Activator a-769662 Inhibits Mitogenic Signaling in Pancreatic Cancer Cells

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-188-S-188

2012

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S1708 PKD Selectively Prolongs ERK Signaling and Potentiates DNA Synthesis in Response to Gq-Coupled Receptor Agonists Through a PKC-Independent but EGFR-Dependent Pathway

Gastroenterology (New York, N.Y. 1943), 2010, Vol.138 (5), p.S-258-S-258

2010

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S1709 Sustained PKD Activation by Gq-Coupled Receptors is Mediated by PKC-Independent Regulation of Activation Loop Ser744 and Ser748 Phosphorylation

Gastroenterology (New York, N.Y. 1943), 2010, Vol.138 (5), p.S-258-S-258

2010

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Introduction of a polar core into the de novo designed protein T op7

Protein science, 2016-07, Vol.25 (7), p.1299-1307

2016

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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV‑2 Neutralization

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

Computationally Designed ACE2 Decoy Receptor Binds SARS-CoV‑2 Spike (S) Protein with Tight Nanomolar Affinity

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization

Introduction of a polar core into the de novo designed protein Top7

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

Sensitivity estimation for calculated phase equilibria

542 oral CLINICAL IMPLEMENTATION OF A PROTOCOL FOR PATIENTS CARRYING A PACEMAKER OR ICD RECEIVING RADIOTHERAPY

Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: d-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

Sa1729 Protein Kinase D1 Is an Upstream Kinase for Class II Histone Deacetylases (HDAC) 4, 5 and 7 in Intestinal Epithelial Cells

299 Identification of Protein Kinase D1 as an Upstream Kinase of Class II Histone Deacetylases (HDAC) 4 and 7 in Intestinal Epithelial Cells

Mo1648 Protein Kinase D1 Mediates Mitogenic Signaling in Intestinal Epithelial Cells

649 Synergistic Inhibition of Pancreatic Cancer Cell Proliferation by Metformin and Rapamycin: Identification of a Novel Combinatorial Drug Strategy

Protein Kinase D1 Mediates Mitogenic Signaling in Intestinal Epithelial IEC-6 and IEC-18 Cells

Transgenic Protein Kinase D1 Stimulates the Rate of Epithelial Cell Proliferation in Intestinal Crypts

Mo1644 Protein Kinase D1 (Pkd1) Mediates β-Catenin Signaling and Phosphorylation at Ser552 in Intestinal Epithelial Cells

1062 The Direct AMPK Activator a-769662 Inhibits Mitogenic Signaling in Pancreatic Cancer Cells

S1708 PKD Selectively Prolongs ERK Signaling and Potentiates DNA Synthesis in Response to Gq-Coupled Receptor Agonists Through a PKC-Independent but EGFR-Dependent Pathway

S1709 Sustained PKD Activation by Gq-Coupled Receptors is Mediated by PKC-Independent Regulation of Activation Loop Ser744 and Ser748 Phosphorylation

Introduction of a polar core into the de novo designed protein T op7

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