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Fatty acid synthase and cancer : New application of an old pathway

Cancer research (Chicago, Ill.), 2006-06, Vol.66 (12), p.5977-5980

KUHAJDA, Francis P

2006

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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

Nutrition, 2000-03, Vol.16 (3), p.202-208

Kuhajda, Francis P

2000

Volltextzugriff (PDF)

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

PloS one, 2014-12, Vol.9 (12), p.e115642-e115642

2014

Volltextzugriff (PDF)

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

The Journal of biological chemistry, 2004-05, Vol.279 (19), p.19970-19976

2004

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Inhibiting Fatty Acid Synthase for Chemoprevention of Chemically Induced Lung Tumors

Clinical cancer research, 2008-04, Vol.14 (8), p.2458-2464

2008

Volltextzugriff (PDF)

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells

Oncogene, 2005-05, Vol.24 (22), p.3574-3582

2005

Volltextzugriff (PDF)

Synthesis and Antitumor Activity of an Inhibitor of Fatty Acid Synthase

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (7), p.3450-3454

2000

Volltextzugriff (PDF)

Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment

Clinical cancer research, 2007-12, Vol.13 (23), p.7139-7145

2007

Volltextzugriff (PDF)

Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells

Cancer research (Chicago, Ill.), 2007-04, Vol.67 (7), p.2964-2971

2007

Volltextzugriff (PDF)

C75 Increases Peripheral Energy Utilization and Fatty Acid Oxidation in Diet-Induced Obesity

Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (14), p.9498-9502

2002

Volltextzugriff (PDF)

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

American journal of physiology. Regulatory, integrative and comparative physiology, 2011-07, Vol.301 (1), p.R116-R130

2011

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Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.946-961

2005

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Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass

American journal of physiology: endocrinology and metabolism, 2004-07, Vol.287 (1), p.E97-E104

2004

Volltextzugriff (PDF)

Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment

American journal of physiology: endocrinology and metabolism, 2002-11, Vol.283 (5), p.E867-E879

2002

Volltextzugriff (PDF)

Increased Fatty Acid Synthase is a Therapeutic Target in Mesothelioma

Clinical cancer research, 2001-01, Vol.7 (1), p.153-157

2001

Volltextzugriff (PDF)

C75 Alters Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure

Endocrinology (Philadelphia), 2005-01, Vol.146 (1), p.486-493

2005

Volltextzugriff (PDF)

The connections between C75 and obesity drug-target pathways

Trends in pharmacological sciences (Regular ed.), 2005-11, Vol.26 (11), p.541-544

2005

Volltextzugriff (PDF)

Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients

Cancer letters, 2001-06, Vol.167 (1), p.99-104

2001

Volltextzugriff (PDF)

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Science (American Association for the Advancement of Science), 2000-06, Vol.288 (5475), p.2379-2381

2000

Volltextzugriff (PDF)

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

Oncogene, 2005-01, Vol.24 (1), p.39-46

2005

Volltextzugriff (PDF)

Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats

American journal of physiology. Regulatory, integrative and comparative physiology, 2006-07, Vol.291 (1), p.R148-R154

2006

Volltextzugriff (PDF)

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (7), p.3450-3454

2000

Volltextzugriff (PDF)

FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer

Pharmaceutical research, 2007-06, Vol.24 (6), p.1202-1207

2007

Volltextzugriff (PDF)

Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (9), p.4300-4305

1997

Volltextzugriff (PDF)

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells

Cancer research (Chicago, Ill.), 2003-11, Vol.63 (21), p.7330-7337

2003

Volltextzugriff (PDF)

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Fatty acid synthase and cancer : New application of an old pathway

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Inhibiting Fatty Acid Synthase for Chemoprevention of Chemically Induced Lung Tumors

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells

Synthesis and Antitumor Activity of an Inhibitor of Fatty Acid Synthase

Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment

Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells

C75 Increases Peripheral Energy Utilization and Fatty Acid Oxidation in Diet-Induced Obesity

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase

Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass

Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment

Increased Fatty Acid Synthase is a Therapeutic Target in Mesothelioma

C75 Alters Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure

The connections between C75 and obesity drug-target pathways

Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer

Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells

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