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Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease

Brain (London, England : 1878), 2015-09, Vol.138 (Pt 9), p.2687-2700

2015

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A Phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for the treatment of status epilepticus in pediatric Japanese subjects

Epilepsy research, 2021-08, Vol.174, p.106651, Article 106651

2021

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AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

Journal of Alzheimer's disease, 2016-01, Vol.50 (4), p.1109

2016

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AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease

Journal of Alzheimer's disease, 2017-01, Vol.55 (3), p.1039

2017

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Pregabalin Add‐on Treatment: A Randomized, Double‐blind, Placebo‐controlled, Dose–Response Study in Adults with Partial Seizures

Epilepsia (Copenhagen), 2004-01, Vol.45 (1), p.20-27

2004

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Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy

Neurology, 2005-02, Vol.64 (3), p.475

2005

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Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures

Neurology, 2003-05, Vol.60 (10), p.1631

2003

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Virulence and antimicrobial resistance determinants of verotoxigenic Escherichia coli (VTEC) and of multidrug-resistant E. coli from foods of animal origin illegally imported to the EU by flight passengers

International journal of food microbiology, 2015-09, Vol.209, p.52-59

2015

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Pharmacokinetics, Safety, and Tolerability of SHP465 Mixed Amphetamine Salts After Administration of Multiple Daily Doses in Children Aged 4–5 Years with Attention-Deficit/Hyperactivity Disorder

CNS drugs, 2022-01, Vol.36 (1), p.71-81

2022

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Evidence of a charge-density threshold for optimum efficiency of biocidal cationic surfaces

Microbiology (Society for General Microbiology), 2005-05, Vol.151 (Pt 5), p.1341

2005

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Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis

Journal of antimicrobial chemotherapy, 2012-04, Vol.67 (4), p.970-976

2012

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BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid A[beta] Peptides

Journal of clinical pharmacology, 2017-11, Vol.57 (11), p.1460

2017

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BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides

Journal of clinical pharmacology, 2017-11, Vol.57 (11), p.1460-1471

2017

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A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma

Pharmaceutical research, 1993-02, Vol.10 (2), p.276-281

1993

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Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications

Neurotoxicity research, 2015-10, Vol.28 (3), p.185-194

2015

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Polyelectrolyte-supported lipid membranes

Bioelectrochemistry (Amsterdam, Netherlands), 2002-05, Vol.56 (1), p.175-178

2002

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5.20 PHARMACOKINETICS, SAFETY, AND TOLERABILITY OF SHP465 MIXED AMPHETAMINE SALTS AFTER MULTIPLE DAILY DOSES IN CHILDREN AGED 4-5 YEARS WITH ADHD

Journal of the American Academy of Child and Adolescent Psychiatry, 2020-10, Vol.59 (10), p.S155-S155

2020

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Clinically Negligible Pharmacokinetic and Pharmacodynamic Interactions Between Lanabecestat and Dabigatran Etexilate, a Prototypical P‐gp Substrate

Journal of clinical pharmacology, 2020-05, Vol.60 (5), p.586-594

2020

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PK/PD MODELING OF AZD3293, A NOVEL BACE1 INHIBITOR FOR ALZHEIMER’S DISEASE IN HEALTHY SUBJECTS AND PATIENTS WITH ALZHEIMER’S DISEASE

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P613-P613

2016

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Pharmacology and pharmacokinetics of fosphenytoin

Neurology, 1996-06, Vol.46 (6 Suppl 1), p.S3

1996

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Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney

Antimicrobial Agents and Chemotherapy, 2003-02, Vol.47 (2), p.689-696

2003

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Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study

Clinical pharmacology in drug development, 2015-11, Vol.4 (6), p.434-441

2015

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Simultaneous quantitation of the BACE1 inhibitor AZD3293 and its metabolite AZ13569724 in human matrices by LC-MS/MS

Bioanalysis, 2017-05, Vol.9 (9), p.813-826

2017

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ASSESSMENT OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFECTS ON PLASMA AND CEREBROSPINAL FLUID AB PEPTIDES OF AZD3293, A NOVEL BACE1 INHIBITOR, IN HEALTHY JAPANESE ADULTS

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P608-P609

2016

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Influence of the Polymethacrylate Chain Conformation in Langmuir-Blodgett-Kuhn Films on the Glass-Transition Temperature

Macromolecular chemistry and physics, 2002-04, Vol.203 (7), p.923-930

2002

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Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease

A Phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for the treatment of status epilepticus in pediatric Japanese subjects

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease

Pregabalin Add‐on Treatment: A Randomized, Double‐blind, Placebo‐controlled, Dose–Response Study in Adults with Partial Seizures

Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy

Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures

Virulence and antimicrobial resistance determinants of verotoxigenic Escherichia coli (VTEC) and of multidrug-resistant E. coli from foods of animal origin illegally imported to the EU by flight passengers

Pharmacokinetics, Safety, and Tolerability of SHP465 Mixed Amphetamine Salts After Administration of Multiple Daily Doses in Children Aged 4–5 Years with Attention-Deficit/Hyperactivity Disorder

Evidence of a charge-density threshold for optimum efficiency of biocidal cationic surfaces

Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis

BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid A[beta] Peptides

BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides

A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma

Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications

Polyelectrolyte-supported lipid membranes

5.20 PHARMACOKINETICS, SAFETY, AND TOLERABILITY OF SHP465 MIXED AMPHETAMINE SALTS AFTER MULTIPLE DAILY DOSES IN CHILDREN AGED 4-5 YEARS WITH ADHD

Clinically Negligible Pharmacokinetic and Pharmacodynamic Interactions Between Lanabecestat and Dabigatran Etexilate, a Prototypical P‐gp Substrate

PK/PD MODELING OF AZD3293, A NOVEL BACE1 INHIBITOR FOR ALZHEIMER’S DISEASE IN HEALTHY SUBJECTS AND PATIENTS WITH ALZHEIMER’S DISEASE

Pharmacology and pharmacokinetics of fosphenytoin

Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney

Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study

Simultaneous quantitation of the BACE1 inhibitor AZD3293 and its metabolite AZ13569724 in human matrices by LC-MS/MS

ASSESSMENT OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFECTS ON PLASMA AND CEREBROSPINAL FLUID AB PEPTIDES OF AZD3293, A NOVEL BACE1 INHIBITOR, IN HEALTHY JAPANESE ADULTS

Influence of the Polymethacrylate Chain Conformation in Langmuir-Blodgett-Kuhn Films on the Glass-Transition Temperature

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