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Chromatin and beyond: the multitasking roles for SIRT6

Trends in biochemical sciences (Amsterdam. Regular ed.), 2014-02, Vol.39 (2), p.72-81

2014

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Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

Nature communications, 2021-02, Vol.12 (1), p.1072-1072, Article 1072

2021

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Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2940-2951

2009

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Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter

Molecular pharmacology, 2011-12, Vol.80 (6), p.1096-1107

2011

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Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Cell reports (Cambridge), 2015-10, Vol.13 (3), p.479-488

2015

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Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter

The Journal of biological chemistry, 2012-02, Vol.287 (7), p.4982-4995

2012

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Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

Biochemical journal, 2015-07, Vol.469 (1), p.33-44

2015

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Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1758-1770

2012

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Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry

Journal of medicinal chemistry, 2010-02, Vol.53 (3), p.1306-1318

2010

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Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter

Cancer chemotherapy and pharmacology, 2013-04, Vol.71 (4), p.999-1011

2013

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Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer

Cancer cell, 2020-10, Vol.38 (4), p.443-445

2020

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The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

Cancer biology & therapy, 2012-12, Vol.13 (14), p.1355-1373

2012

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SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

Cell, 2016-06, Vol.165 (6), p.1401-1415

2016

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The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

Nature cell biology, 2015-05, Vol.17 (5), p.545

2015

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SIRT1 activators: the evidence STACks up

Aging (Albany, NY.), 2013-03, Vol.5 (3), p.142-143

2013

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Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT&Tag

Nature communications, 2023-09, Vol.14 (1), p.5930, Article 5930

2023

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The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

Leukemia, 2009-08, Vol.23 (8), p.1417-1425

2009

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SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma

Science translational medicine, 2024-05, Vol.16 (747), p.eadj7685

2024

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Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases

Science translational medicine, 2023-05, Vol.15 (694), p.eabn9674

2023

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Abstract B44: The histone deacetylase SIRT6 regulates metabolism in pancreatic ductal adenocarcinoma

Cancer research (Chicago, Ill.), 2015-07, Vol.75 (13_Supplement), p.B44-B44

2015

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Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT Tag

Nature communications, 2023-09, Vol.14 (1), p.1-17

2023

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Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7150-7164

2011

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Abstract 783: Identification of structural determinants of human proton-coupled folate transporter oligomerization

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.783-783

2014

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Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter

Molecular pharmacology, 2012-10, Vol.82 (4), p.591-600

2012

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Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors

Molecular pharmacology, 2010-10, Vol.78 (4), p.577-587

2010

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Chromatin and beyond: the multitasking roles for SIRT6

Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry

Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter

Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier

Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry

Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter

Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

SIRT1 activators: the evidence STACks up

Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT&Tag

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases

Abstract B44: The histone deacetylase SIRT6 regulates metabolism in pancreatic ductal adenocarcinoma

Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT Tag

Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase

Abstract 783: Identification of structural determinants of human proton-coupled folate transporter oligomerization

Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter

Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors

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