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Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey

Psychopharmacology, 2015-06, Vol.232 (11), p.1859-1866

2015

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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Sleep (New York, N.Y.), 2016-03, Vol.39 (3), p.603-612

2016

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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

BMC neuroscience, 2013-08, Vol.14 (1), p.90-90, Article 90

2013

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MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.652-656

2018

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Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5809-5814

2016

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Synthesis of 4‑Alkylated Isocoumarins via Pd-Catalyzed α‑Arylation Reaction

Organic letters, 2020-10, Vol.22 (19), p.7662-7666

2020

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Fully Synthetic Carbohydrate-Based Vaccines in Biochemically Relapsed Prostate Cancer: Clinical Trial Results With α-N-Acetylgalactosamine-O-Serine/Threonine Conjugate Vaccine

Journal of clinical oncology, 2003-12, Vol.21 (23), p.4292-4298

2003

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Tandem Amination/Oxetane Ring Opening toward Benzomorpholines

Journal of organic chemistry, 2021-12, Vol.86 (23), p.17482-17486

2021

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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

Antimicrobial agents and chemotherapy, 2019-01, Vol.63 (1)

2019

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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6), p.1364-1370

2017

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Mild Intramolecular Ring Opening of Oxetanes

Organic letters, 2019-12, Vol.21 (23), p.9642-9645

2019

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Tetrabutylammonium Salt Induced Denitration of Nitropyridines: Synthesis of Fluoro-, Hydroxy-, and Methoxypyridines

Organic letters, 2005-02, Vol.7 (4), p.577-579

2005

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Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

Frontiers in behavioral neuroscience, 2014-05, Vol.8, p.182-182

2014

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Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems

Organic letters, 2020-08, Vol.22 (15), p.5828-5832

2020

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The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys

The Journal of pharmacology and experimental therapeutics, 2015-12, Vol.355 (3), p.442-450

2015

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Oxadiazepinone HBV capsid assembly modulators

Bioorganic & medicinal chemistry letters, 2021-11, Vol.52, p.128353-128353, Article 128353

2021

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Diazepinone HBV capsid assembly modulators

Bioorganic & medicinal chemistry letters, 2022-09, Vol.72, p.128823-128823, Article 128823

2022

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Di-fluoro azepane HBV capsid assembly modulators

Bioorganic & medicinal chemistry letters, 2023-08, Vol.92, p.129350-129350, Article 129350

2023

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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.11254-11272

2024

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Identification of a new class of HBV capsid assembly modulator

Bioorganic & medicinal chemistry letters, 2021-05, Vol.39, p.127848-127848, Article 127848

2021

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N‑Heterocyclic 3‑Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11241-11256

2022

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Identification of isoquinolinone DHODH inhibitor isosteres

Bioorganic & medicinal chemistry letters, 2024-11, Vol.113, p.129965, Article 129965

2024

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The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model

Behavioural brain research, 2015-07, Vol.287, p.96-99

2015

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Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators

Frontiers in neuroscience, 2013-01, Vol.7, p.254-254

2013

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SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2405-2409

2019

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Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology

Synthesis of 4‑Alkylated Isocoumarins via Pd-Catalyzed α‑Arylation Reaction

Fully Synthetic Carbohydrate-Based Vaccines in Biochemically Relapsed Prostate Cancer: Clinical Trial Results With α-N-Acetylgalactosamine-O-Serine/Threonine Conjugate Vaccine

Tandem Amination/Oxetane Ring Opening toward Benzomorpholines

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists

Mild Intramolecular Ring Opening of Oxetanes

Tetrabutylammonium Salt Induced Denitration of Nitropyridines: Synthesis of Fluoro-, Hydroxy-, and Methoxypyridines

Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems

The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys

Oxadiazepinone HBV capsid assembly modulators

Diazepinone HBV capsid assembly modulators

Di-fluoro azepane HBV capsid assembly modulators

Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML

Identification of a new class of HBV capsid assembly modulator

N‑Heterocyclic 3‑Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia

Identification of isoquinolinone DHODH inhibitor isosteres

The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators

SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators

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