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Too hot? Too cold? Wnt signalling in pulmonary arterial hypertension: can we treat it "just right"?

The European respiratory journal, 2023-06, Vol.61 (6), p.2300504

2023

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Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

Circulation (New York, N.Y.), 2014-02, Vol.129 (8), p.864-874

2014

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Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats

American journal of respiratory cell and molecular biology, 2017-11, Vol.57 (5), p.615-625

2017

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MAPKs Are Highly Abundant but Do Not Contribute to α1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period

International journal of molecular sciences, 2021-06, Vol.22 (11), p.6037

2021

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Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension

International journal of molecular sciences, 2018-09, Vol.19 (10), p.2957

2018

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GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension

Scientific reports, 2023-04, Vol.13 (1), p.6593-6593, Article 6593

2023

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EnFUSiasm for Healing: Ultrasound Neuromodulation in PAH

Circulation research, 2024-06, Vol.135 (1), p.57-59

2024

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MonOrail to Cure? Targeting Orai1 to Reverse Pulmonary Arterial Hypertension

Circulation research, 2022-10, Vol.131 (9), p.728-730

2022

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What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension

American journal of respiratory and critical care medicine, 2024-06, Vol.209 (11), p.1298-1300

2024

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Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts

PloS one, 2014-10, Vol.9 (10), p.e111476-e111476

2014

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Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension

Journal of the American Heart Association, 2023-04, Vol.12 (7), p.e027894

2023

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Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension

Frontiers in medicine, 2022-06, Vol.9, p.886868-886868

2022

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Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf's Skin?

American journal of respiratory and critical care medicine, 2021-12, Vol.204 (12), p.1361-1363

2021

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Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats

Pulmonary circulation, 2020-01, Vol.10 (1), p.1-12

2020

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HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

American journal of respiratory and critical care medicine, 2016-10, Vol.194 (7), p.866-877

2016

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UnWNTing the Heart: Targeting WNT Signaling in Pulmonary Arterial Hypertension

Circulation research, 2023-05, Vol.132 (11), p.1486-1488

2023

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Seeing pulmonary hypertension through a paediatric lens: a viewpoint

The European respiratory journal, 2024-06, Vol.63 (6), p.2301518

2024

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RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

The Journal of clinical investigation, 2024-02, Vol.134 (3), p.1-14

2024

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Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

Science signaling, 2022-12, Vol.15 (763), p.eabn2743

2022

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PAI-1 deficiency drives pulmonary vascular smooth muscle remodeling and pulmonary hypertension

American journal of physiology. Lung cellular and molecular physiology, 2024-09, Vol.327 (3), p.L319-L326

2024

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Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension

Pulmonary circulation, 2015-12, Vol.5 (4), p.667-680

2015

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HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

American journal of respiratory and critical care medicine, 2016-10, Vol.194 (7), p.866

2016

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Too hot? Too cold? Wnt signalling in pulmonary arterial hypertension: can we treat it "just right"?

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats

MAPKs Are Highly Abundant but Do Not Contribute to α1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period

Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension

GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension

EnFUSiasm for Healing: Ultrasound Neuromodulation in PAH

MonOrail to Cure? Targeting Orai1 to Reverse Pulmonary Arterial Hypertension

What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension

Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts

Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension

Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension

Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf's Skin?

Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats

HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

UnWNTing the Heart: Targeting WNT Signaling in Pulmonary Arterial Hypertension

Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

Seeing pulmonary hypertension through a paediatric lens: a viewpoint

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

PAI-1 deficiency drives pulmonary vascular smooth muscle remodeling and pulmonary hypertension

Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension

Non-Canonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

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