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AggScore: Prediction of aggregation‐prone regions in proteins based on the distribution of surface patches

Proteins, structure, function, and bioinformatics, 2018-11, Vol.86 (11), p.1147-1156

2018

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Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry

Analytical chemistry (Washington), 2016-02, Vol.88 (4), p.2041-2050

2016

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Design for Solubility May Reveal Induction of Amide Hydrogen/Deuterium Exchange by Protein Self-Association

Journal of molecular biology, 2022-01, Vol.434 (2), p.167398-167398, Article 167398

2022

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Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint

Structure (London), 2012-02, Vol.20 (2), p.259-269

2012

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Development and scale-up of the recovery and purification of a domain antibody Fc fusion protein-comparison of a two and three-step approach

Biotechnology and bioengineering, 2015-07, Vol.112 (7), p.1417-1428

2015

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Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Analytical chemistry (Washington), 2017-02, Vol.89 (4), p.2250-2258

2017

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Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction

mAbs, 2018-01, Vol.10 (1), p.95-103

2018

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Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen–Deuterium Exchange Mass Spectrometry, and Computational Analysis

Journal of pharmaceutical sciences, 2017-11, Vol.106 (11), p.3222-3229

2017

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope

Journal of molecular biology, 2016-07, Vol.428 (14), p.2860-2879

2016

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Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Endocrinology (Philadelphia), 2007-01, Vol.148 (1), p.4-12

2007

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Loopholes and missing links in protein modeling

Protein science, 2007-09, Vol.16 (9), p.1999-2012

2007

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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold

Journal of medicinal chemistry, 2006-12, Vol.49 (26), p.7596-7599

2006

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Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3015-3025

2007

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Biotechnology Based Process for Production of a Disulfide-Bridged Peptide

Bioconjugate chemistry, 2016-05, Vol.27 (5), p.1276-1284

2016

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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2794-2798

2009

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Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2017-05, Vol.28 (5), p.795-802

2017

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Chemical genetics reveals an RGS/G-protein role in the action of a compound

PLoS genetics, 2006-04, Vol.2 (4), p.e57-e57

2006

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Closing the side-chain gap in protein loop modeling

Journal of computer-aided molecular design, 2009-07, Vol.23 (7), p.411-418

2009

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Crystallographic Structures of the Ligand-Binding Domains of the Androgen Receptor and Its T877A Mutant Complexed with the Natural Agonist Dihydrotestosterone

Proceedings of the National Academy of Sciences - PNAS, 2001-04, Vol.98 (9), p.4904-4909

2001

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Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1860-1864

2007

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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4291-4317

2022

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The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6107-6111

2004

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Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics

Expert review of proteomics, 2015-04, Vol.12 (2), p.159-169

2015

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Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor

Journal of computer-aided molecular design, 2006-08, Vol.20 (7-8), p.463-470

2006

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AggScore: Prediction of aggregation‐prone regions in proteins based on the distribution of surface patches

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry

Design for Solubility May Reveal Induction of Amide Hydrogen/Deuterium Exchange by Protein Self-Association

Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint

Development and scale-up of the recovery and purification of a domain antibody Fc fusion protein-comparison of a two and three-step approach

Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis

Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction

Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen–Deuterium Exchange Mass Spectrometry, and Computational Analysis

Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope

Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Loopholes and missing links in protein modeling

Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold

Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

Biotechnology Based Process for Production of a Disulfide-Bridged Peptide

N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

Chemical genetics reveals an RGS/G-protein role in the action of a compound

Closing the side-chain gap in protein loop modeling

Crystallographic Structures of the Ligand-Binding Domains of the Androgen Receptor and Its T877A Mutant Complexed with the Natural Agonist Dihydrotestosterone

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists

Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics

Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor

Outcome of a Workshop on Applications of Protein Models in Biomedical Research

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