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Functions of the influenza A virus NS1 protein in antiviral defense

Current opinion in virology, 2015-06, Vol.12, p.1-6

Krug, Robert M

2015

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Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14048-14053

2015

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Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein

Cell host & microbe, 2014-04, Vol.15 (4), p.484-493

2014

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The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

Nature, 2006-12, Vol.444 (7122), p.1078-1082

2006

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Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

Cell host & microbe, 2013-10, Vol.14 (4), p.435-445

2013

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Modeling mitigation of influenza epidemics by baloxavir

Nature communications, 2020-06, Vol.11 (1), p.2750-2750, Article 2750

2020

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Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

Nature communications, 2016-09, Vol.7 (1), p.12754-12754, Article 12754

2016

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Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein

Nature structural & molecular biology, 1997-11, Vol.4 (11), p.896-899

1997

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Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation

Cell host & microbe, 2017-11, Vol.22 (5), p.627-638.e7

2017

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Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

Cell reports (Cambridge), 2021-05, Vol.35 (7), p.109133-109133, Article 109133

2021

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The Primary Function of RNA Binding by the Influenza a Virus NS1 Protein in Infected Cells: Inhibiting the 2'-5' Oligo (A) Synthetase/RNase L Pathway

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.7100-7105

2006

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Interferon-induced ISG15 pathway: an ongoing virus–host battle

Trends in microbiology (Regular ed.), 2013-04, Vol.21 (4), p.181-186

2013

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ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (5), p.2253-2258

2010

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Public Health Impact of Paxlovid as Treatment for COVID-19, United States

Emerging infectious diseases, 2024-02, Vol.30 (2), p.262-269

2024

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Influenza A Virus Polymerase Is an Integral Component of the CPSF30-NS1A Protein Complex in Infected Cells

Journal of Virology, 2009-02, Vol.83 (4), p.1611-1616

2009

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Human ISG15 Conjugation Targets Both IFN-Induced and Constitutively Expressed Proteins Functioning in Diverse Cellular Pathways

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (29), p.10200-10205

2005

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Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

Journal of Virology, 2009-06, Vol.83 (12), p.5971-5977

2009

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A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis

Virology (New York, N.Y.), 2007-06, Vol.363 (1), p.236-243

2007

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Roles of the Phosphorylation of Specific Serines and Threonines in the NS1 Protein of Human Influenza A Viruses

Journal of Virology, 2012-10, Vol.86 (19), p.10370-10376

2012

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Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA

Virology (New York, N.Y.), 2006-05, Vol.349 (1), p.13-21

2006

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A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

eLife, 2024-04, Vol.13

2024

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Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells

The Journal of biological chemistry, 2006-02, Vol.281 (7), p.4334-4338

2006

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Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals

Frontiers in chemistry, 2022-10, Vol.10, p.948553-948553

2022

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Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools

mBio, 2018-07, Vol.9 (4)

2018

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Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis

Journal of Virology, 2012-07, Vol.86 (13), p.7292-7297

2012

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Functions of the influenza A virus NS1 protein in antiviral defense

Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein

Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein

The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

Modeling mitigation of influenza epidemics by baloxavir

Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein

Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

The Primary Function of RNA Binding by the Influenza a Virus NS1 Protein in Infected Cells: Inhibiting the 2'-5' Oligo (A) Synthetase/RNase L Pathway

Interferon-induced ISG15 pathway: an ongoing virus–host battle

ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells

Public Health Impact of Paxlovid as Treatment for COVID-19, United States

Influenza A Virus Polymerase Is an Integral Component of the CPSF30-NS1A Protein Complex in Infected Cells

Human ISG15 Conjugation Targets Both IFN-Induced and Constitutively Expressed Proteins Functioning in Diverse Cellular Pathways

Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis

Roles of the Phosphorylation of Specific Serines and Threonines in the NS1 Protein of Human Influenza A Viruses

Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA

A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells

Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals

Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools

Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis

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