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Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies

Cold Spring Harbor perspectives in medicine, 2019-11, Vol.9 (11), p.a033548

2019

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Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (41), p.14918-14923

2014

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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

Nature neuroscience, 2011-06, Vol.14 (6), p.711-717

2011

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Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea

The Journal of physiology, 2020-01, Vol.598 (1), p.151-170

2020

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Preferential Cochleotoxicity of Cisplatin

Frontiers in neuroscience, 2021-07, Vol.15, p.695268-695268

2021

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Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells

Cell death & disease, 2018-09, Vol.9 (9), p.922-13, Article 922

2018

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Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

PloS one, 2011-04, Vol.6 (4), p.e19183-e19183

2011

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Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature communications, 2018-10, Vol.9 (1), p.4015-15, Article 4015

2018

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Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells

The Journal of neuroscience, 2016-01, Vol.36 (2), p.336-349

2016

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Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel

Journal of medicinal chemistry, 2019-06, Vol.62 (11), p.5312-5329

2019

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Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells

The EMBO journal, 2019-05, Vol.38 (9), p.n/a

2019

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Wake up your ears! ATP sculpts development along the auditory system

The Journal of physiology, 2017-02, Vol.595 (4), p.1019-1020

Kros, Corné J.

2017

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The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano -electrical transducer channels

The Journal of physiology, 2005-09, Vol.567 (2), p.505-521

2005

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Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel

The Journal of neuroscience, 2014-04, Vol.34 (16), p.5505-5514

2014

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The acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI

The Journal of physiology, 2016-07, Vol.594 (13), p.3667-3681

2016

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TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

Open biology, 2012-05, Vol.2 (5), p.120068-120068

2012

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Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses

Human molecular genetics, 2009-12, Vol.18 (23), p.4615-4628

2009

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Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells

Frontiers in cellular neuroscience, 2019-09, Vol.13, p.416

2019

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d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Frontiers in cellular neuroscience, 2017-09, Vol.11, p.262

2017

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Development and properties of stereociliary link types in hair cells of the mouse cochlea

Journal of comparative neurology (1911), 2005-04, Vol.485 (1), p.75-85

2005

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The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

Neuroscience letters, 2016-01, Vol.610, p.36-42

2016

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Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea

The Journal of physiology, 2006-08, Vol.574 (3), p.677-698

2006

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TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells

Frontiers in molecular neuroscience, 2017-10, Vol.10, p.326-326

2017

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Drug-induced hearing loss: Infection raises the odds

Science translational medicine, 2015-07, Vol.7 (298), p.298fs31

2015

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Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells

The Journal of physiology, 2005-02, Vol.563 (1), p.177-191

2005

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Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies

Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells

Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea

Preferential Cochleotoxicity of Cisplatin

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells

Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel

Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells

Wake up your ears! ATP sculpts development along the auditory system

The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano -electrical transducer channels

Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel

The acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses

Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Development and properties of stereociliary link types in hair cells of the mouse cochlea

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea

TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells

Drug-induced hearing loss: Infection raises the odds

Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells

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