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Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7621-7638

2011

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Metabolism of retigabine (D-23129), a novel anticonvulsant

Drug metabolism and disposition, 1999-05, Vol.27 (5), p.613

1999

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Retigabine N-glucuronidation and its potential role in enterohepatic circulation

Drug metabolism and disposition, 1999-05, Vol.27 (5), p.605

1999

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[49] Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6

Methods in Enzymology, 1991, Vol.206, p.509-517

Kronbach, Thomas

1991

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Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Cellular signalling, 2001-04, Vol.13 (4), p.287-297

2001

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Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

Journal of medicinal chemistry, 2010-06, Vol.53 (11), p.4399-4411

2010

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High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

Analytical biochemistry, 1987-04, Vol.162 (1), p.24-32

1987

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Novel triazines as potent and selective phosphodiesterase 10A inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5876-5884

2012

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New metabolic pathways of alpha-lipoic acid

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.855

2001

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Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography

Analytical biochemistry, 1985-12, Vol.151 (2), p.286-291

1985

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Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

Clinical pharmacology and therapeutics, 1988-06, Vol.43 (6), p.630-635

1988

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Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

Clinical pharmacology and therapeutics, 1985-11, Vol.38 (5), p.488-494

1985

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Refolding and Purification of Recombinant Human PDE7A Expressed in Escherichia coli as Inclusion Bodies

Protein expression and purification, 2002-06, Vol.25 (1), p.138-148

2002

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Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis

Cellular signalling, 2001-03, Vol.13 (3), p.159-167

2001

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Disposition and metabolism of cetrorelix, a potent luteinizing hormone-releasing hormone antagonist, in rats and dogs

Drug metabolism and disposition, 2000-01, Vol.28 (1), p.10

2000

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Refolding, Purification, and Characterization of Human Recombinant PDE4A Constructs Expressed in Escherichia coli

Protein expression and purification, 2000-08, Vol.19 (3), p.375-383

2000

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Identification of Talinolol Metabolites in Urine of Man, Dog, Rat and Mouse after Oral Administration by High-Performance Liquid Chromatography-Thermospray Tandem Mass Spectrometry

Journal of mass spectrometry., 1996-12, Vol.31 (12), p.1371-1381

1996

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A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1

Biochemistry (Easton), 1991-06, Vol.30 (25), p.6097-6102

1991

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An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5

The Journal of biological chemistry, 1991-04, Vol.266 (10), p.6215-6220

1991

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Hybrid Cytochromes P-450 Identify a Substrate Binding Domain in P-450IIC5 and P-450IIC4

Proceedings of the National Academy of Sciences - PNAS, 1989-11, Vol.86 (21), p.8262-8265

1989

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In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

Clinical pharmacology and therapeutics, 1989-01, Vol.45 (1), p.28-33

1989

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Analysis of the catalytic specificity of cytochrome P450 enzymes through site‐directed mutagenesis

The FASEB journal, 1992-01, Vol.6 (2), p.700-705

1992

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Properties of expressed and native flavin-containing monooxygenases: evidence of multiple forms in rabbit liver and lung

Molecular pharmacology, 1991-11, Vol.40 (5), p.692-698

1991

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Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation: Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency

Biochemical pharmacology, 1987-12, Vol.36 (23), p.4145-4152

1987

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A simple high-performance liquid chromatographic pre-column technique for investigation of drug metabolism in biological fluids

Journal of Chromatography A, 1982-04, Vol.239, p.475-482

1982

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Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Metabolism of retigabine (D-23129), a novel anticonvulsant

Retigabine N-glucuronidation and its potential role in enterohepatic circulation

[49] Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

Novel triazines as potent and selective phosphodiesterase 10A inhibitors

New metabolic pathways of alpha-lipoic acid

Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

Refolding and Purification of Recombinant Human PDE7A Expressed in Escherichia coli as Inclusion Bodies

Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis

Disposition and metabolism of cetrorelix, a potent luteinizing hormone-releasing hormone antagonist, in rats and dogs

Refolding, Purification, and Characterization of Human Recombinant PDE4A Constructs Expressed in Escherichia coli

Identification of Talinolol Metabolites in Urine of Man, Dog, Rat and Mouse after Oral Administration by High-Performance Liquid Chromatography-Thermospray Tandem Mass Spectrometry

A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1

An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5

Hybrid Cytochromes P-450 Identify a Substrate Binding Domain in P-450IIC5 and P-450IIC4

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

Analysis of the catalytic specificity of cytochrome P450 enzymes through site‐directed mutagenesis

Properties of expressed and native flavin-containing monooxygenases: evidence of multiple forms in rabbit liver and lung

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation: Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency

A simple high-performance liquid chromatographic pre-column technique for investigation of drug metabolism in biological fluids

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