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In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration

The Journal of pharmacology and experimental therapeutics, 2003-10, Vol.307 (1), p.373-385

2003

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Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4

Molecular pharmacology, 1989-07, Vol.36 (1), p.89-96

1989

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Hybrid Cytochromes P-450 Identify a Substrate Binding Domain in P-450IIC5 and P-450IIC4

Proceedings of the National Academy of Sciences - PNAS, 1989-11, Vol.86 (21), p.8262-8265

1989

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An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5

The Journal of biological chemistry, 1991-04, Vol.266 (10), p.6215-6220

1991

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Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol

The Journal of biological chemistry, 1986-09, Vol.261 (25), p.11734-11743

1986

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Metabolism of retigabine (D-23129), a novel anticonvulsant

Drug metabolism and disposition, 1999-05, Vol.27 (5), p.613

1999

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Purification and Characterization of Recombinant-Expressed Cytochrome P450 2C3 from Escherichia coli: 2C3 Encodes the 6β-Hydroxylase Deficient Form of P450-3b

Archives of biochemistry and biophysics, 1993-01, Vol.300 (1), p.510-516

1993

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New metabolic pathways of alpha-lipoic acid

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.855

2001

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Properties of expressed and native flavin-containing monooxygenases: evidence of multiple forms in rabbit liver and lung

Molecular pharmacology, 1991-11, Vol.40 (5), p.692-698

1991

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Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation: Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency

Biochemical pharmacology, 1987-12, Vol.36 (23), p.4145-4152

1987

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The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

Xenobiotica, 1986, Vol.16 (5), p.449-464

1986

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Retigabine N-glucuronidation and its potential role in enterohepatic circulation

Drug metabolism and disposition, 1999-05, Vol.27 (5), p.605

1999

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Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

Clinical pharmacology and therapeutics, 1988-06, Vol.43 (6), p.630-635

1988

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[49] Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6

Methods in Enzymology, 1991, Vol.206, p.509-517

Kronbach, Thomas

1991

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Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

FEBS letters, 1984-08, Vol.173 (2), p.287-290

1984

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Refolding and Purification of Recombinant Human PDE7A Expressed in Escherichia coli as Inclusion Bodies

Protein expression and purification, 2002-06, Vol.25 (1), p.138-148

2002

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Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Cellular signalling, 2001-04, Vol.13 (4), p.287-297

2001

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Stereo- and regioselectivity of hepatic oxidation in man-effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation

European journal of clinical pharmacology, 1986, Vol.31 (3), p.313-318

1986

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Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis

Cellular signalling, 2001-03, Vol.13 (3), p.159-167

2001

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High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

Analytical biochemistry, 1987-04, Vol.162 (1), p.24-32

1987

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Disposition and metabolism of cetrorelix, a potent luteinizing hormone-releasing hormone antagonist, in rats and dogs

Drug metabolism and disposition, 2000-01, Vol.28 (1), p.10

2000

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Refolding, Purification, and Characterization of Human Recombinant PDE4A Constructs Expressed in Escherichia coli

Protein expression and purification, 2000-08, Vol.19 (3), p.375-383

2000

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Identification of Talinolol Metabolites in Urine of Man, Dog, Rat and Mouse after Oral Administration by High-Performance Liquid Chromatography-Thermospray Tandem Mass Spectrometry

Journal of mass spectrometry., 1996-12, Vol.31 (12), p.1371-1381

1996

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A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1

Biochemistry (Easton), 1991-06, Vol.30 (25), p.6097-6102

1991

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In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

Clinical pharmacology and therapeutics, 1989-01, Vol.45 (1), p.28-33

1989

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In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4

Hybrid Cytochromes P-450 Identify a Substrate Binding Domain in P-450IIC5 and P-450IIC4

An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5

Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol

Metabolism of retigabine (D-23129), a novel anticonvulsant

Purification and Characterization of Recombinant-Expressed Cytochrome P450 2C3 from Escherichia coli: 2C3 Encodes the 6β-Hydroxylase Deficient Form of P450-3b

New metabolic pathways of alpha-lipoic acid

Properties of expressed and native flavin-containing monooxygenases: evidence of multiple forms in rabbit liver and lung

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation: Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency

The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

Retigabine N-glucuronidation and its potential role in enterohepatic circulation

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

[49] Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6

Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

Refolding and Purification of Recombinant Human PDE7A Expressed in Escherichia coli as Inclusion Bodies

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Stereo- and regioselectivity of hepatic oxidation in man-effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation

Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

Disposition and metabolism of cetrorelix, a potent luteinizing hormone-releasing hormone antagonist, in rats and dogs

Refolding, Purification, and Characterization of Human Recombinant PDE4A Constructs Expressed in Escherichia coli

Identification of Talinolol Metabolites in Urine of Man, Dog, Rat and Mouse after Oral Administration by High-Performance Liquid Chromatography-Thermospray Tandem Mass Spectrometry

A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

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