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A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models

Molecular cancer therapeutics, 2014-06, Vol.13 (6), p.1442-1456

2014

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Molecular cancer therapeutics, 2019-12, Vol.18 (12), p.2207-2219

2019

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In Vitro L6 Irritation Assay Predicts Clinical Injection Site Reactions for Small Molecules

Toxicological sciences, 2016-06, Vol.151 (2), p.302-311

2016

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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Investigational new drugs, 2014-10, Vol.32 (5), p.825-837

2014

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Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

Molecular cancer therapeutics, 2003-12, Vol.2 (12), p.1321

2003

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In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations

Human gene therapy, 2003-12, Vol.14 (18), p.1703-1714

2003

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Synthesis and preliminary biological evaluation of O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy

Bioorganic & medicinal chemistry, 2005-10, Vol.13 (20), p.5779-5786

2005

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Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity

Journal of neurosurgery, 2003-03, Vol.98 (3), p.591-598

2003

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Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation

Molecular and cellular endocrinology, 1999-07, Vol.153 (1), p.103-111

1999

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What is your diagnosis? CBC and cytogram data from a S prague‐ D awley rat

Veterinary clinical pathology, 2012-03, Vol.41 (1), p.164-165

2012

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A novel fluorometric oligonucleotide assay to measure O 6-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase

Nucleic acids research, 2001-06, Vol.29 (12), p.2558-2566

Kreklau, E. L.

2001

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A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase

Nucleic acids research, 2001-06, Vol.29 (12), p.2558

2001

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What is your diagnosis? CBC and cytogram data from a Sprague-Dawley rat

Veterinary clinical pathology, 2012-03, Vol.41 (1), p.164-165

2012

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Abstract B233: Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B233-B233

2011

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Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity

The Journal of pharmacology and experimental therapeutics, 2001-05, Vol.297 (2), p.524

2001

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Synthesis and preliminary biological evaluation of O super(6)-[4-(2- [ super(18)F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O super(6)-alkylguanine-DNA alkyltransferase in cancer chemotherapy

Bioorganic & medicinal chemistry, 2005-10, Vol.13 (20), p.5779-5786

2005

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Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo

The Journal of pharmacology and experimental therapeutics, 1999-12, Vol.291 (3), p.1269

1999

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Synthesis and preliminary biological evaluation of O 6-[4-(2-[ 18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O 6-alkylguanine-DNA alkyltransferase in cancer chemotherapy

Bioorganic & medicinal chemistry, 2005-10, Vol.13 (20), p.5779-5786

2005

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Hematopoietic expression of O6-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O6-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

Molecular cancer therapeutics, 2003-12, Vol.2 (12), p.1321

2003

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Cross-resistance to adriamycin in cadmium-resistant human lung carcinoma A549 cells

Kreklau, Emiko Lynn

1997

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A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

In Vitro L6 Irritation Assay Predicts Clinical Injection Site Reactions for Small Molecules

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations

Synthesis and preliminary biological evaluation of O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy

Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity

Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation

What is your diagnosis? CBC and cytogram data from a S prague‐ D awley rat

A novel fluorometric oligonucleotide assay to measure O 6-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase

A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase

What is your diagnosis? CBC and cytogram data from a Sprague-Dawley rat

Abstract B233: Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity

Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity

Synthesis and preliminary biological evaluation of O super(6)-[4-(2- [ super(18)F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O super(6)-alkylguanine-DNA alkyltransferase in cancer chemotherapy

Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo

Synthesis and preliminary biological evaluation of O 6-[4-(2-[ 18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O 6-alkylguanine-DNA alkyltransferase in cancer chemotherapy

Hematopoietic expression of O6-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O6-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

Cross-resistance to adriamycin in cadmium-resistant human lung carcinoma A549 cells

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