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Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

PloS one, 2018-10, Vol.13 (10), p.e0205435-e0205435

2018

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Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling

The AAPS journal, 2017-03, Vol.19 (2), p.534-550

2017

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The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1

Scientific reports, 2019-03, Vol.9 (1), p.4074, Article 4074

2019

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Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

Genomics (San Diego, Calif.), 2005-03, Vol.85 (3), p.372-385

2005

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The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

BMC structural biology, 2007-10, Vol.7 (1), p.66-66, Article 66

2007

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Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9041-9060

2015

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Population pharmacokinetic analysis of RO5459072, a low water‐soluble drug exhibiting complex food–drug interactions

British journal of clinical pharmacology, 2021-09, Vol.87 (9), p.3550-3560

2021

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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Current topics in medicinal chemistry, 2011-08, Vol.11 (15), p.1902

2011

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Partially fluorinated alkoxy groups − Conformational adaptors to changing environments

Journal of fluorine chemistry, 2017-06, Vol.198, p.34-46

2017

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Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

ChemMedChem, 2016-10, Vol.11 (19), p.2216-2239

2016

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Predicting plasma protein binding of drugs: a new approach

Biochemical pharmacology, 2002-11, Vol.64 (9), p.1355-1374

2002

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Functional analysis and transcriptional output of the Göttingen minipig genome

BMC genomics, 2015-11, Vol.16 (1), p.932-932, Article 932

2015

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Nucleotide Platination Induced by Visible Light

Angewandte Chemie (International ed.), 1999-05, Vol.38 (10), p.1460-1463

1999

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Nucleotide Cross-Linking Induced by Photoreactions of Platinum(IV)-Azide Complexes

Angewandte Chemie (International ed.), 2003-01, Vol.42 (3), p.335-339

2003

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An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application

Journal of chemical information and modeling, 2005-09, Vol.45 (5), p.1324-1336

2005

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Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5426-5430

2010

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Population Pharmacokinetics and Exposure-Response Analyses for Glofitamab in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R NHL): Confirmation of Efficacy and CRS Mitigation in Patients with Step-up Dosing

Blood, 2020-11, Vol.136 (Supplement 1), p.1-2

2020

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Synthesis and X-ray Crystal Structure of trans,cis-[Pt(OAc)2I2(en)]: A Novel Type of Cisplatin Analog That Can Be Photolyzed by Visible Light to DNA-Binding and Cytotoxic Species in Vitro

Journal of medicinal chemistry, 1996-06, Vol.39 (13), p.2499-2507

1996

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Surprising Reactions of Iodo Pt(IV) and Pt(II) Complexes with Human Albumin: Detection of Cys34 Sulfenic Acid

Journal of the American Chemical Society, 1999-09, Vol.121 (36), p.8193-8203

1999

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Population Pharmacokinetics and Novel Exposure-Response Analyses to Inform Optimal Biologic Dose Selection for CD20-TCB, a T-Cell-Engaging Bispecific Antibody, in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Blood, 2019-11, Vol.134 (Supplement_1), p.3799-3799

2019

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cis-[PtCl2(NH3){2-(2-hydroxyethyl)pyridine}] − an Analogue of the Anticancer Drug AMD473: Unusual Hydrolysis Rates and pKa Values for the Diaqua Adduct

European journal of inorganic chemistry, 2002-05, Vol.2002 (5), p.1035-1039

2002

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Electron-Transfer-Driven Trans-Ligand Labilization: A Novel Activation Mechanism for Pt(IV) Anticancer Complexes

Journal of the American Chemical Society, 1998-08, Vol.120 (32), p.8253-8254

1998

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CD20-TCB, a Novel T-Cell-Engaging Bispecific Antibody, Induces T-Cell-Mediated Killing in Relapsed or Refractory Non-Hodgkin Lymphoma: Biomarker Results From a Phase I Dose-Escalation Trial

Blood, 2019-11, Vol.134 (Supplement_1), p.5319-5319

2019

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Effect of thiols exported by cancer cells on the stability and growth-inhibitory activity of Pt(IV) complexes

Journal of cancer research and clinical oncology, 1999-12, Vol.125 (12), p.690-696

1999

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[1H, 15N] NMR Studies of the Platination of Phosphorothioate Nucleotides − Monofunctional Sulfur Adducts versus Macrochelation

European journal of inorganic chemistry, 2001-11, Vol.2001 (11), p.2743-2746

2001

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Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling

The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Population pharmacokinetic analysis of RO5459072, a low water‐soluble drug exhibiting complex food–drug interactions

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Partially fluorinated alkoxy groups − Conformational adaptors to changing environments

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

Predicting plasma protein binding of drugs: a new approach

Functional analysis and transcriptional output of the Göttingen minipig genome

Nucleotide Platination Induced by Visible Light

Nucleotide Cross-Linking Induced by Photoreactions of Platinum(IV)-Azide Complexes

An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

Population Pharmacokinetics and Exposure-Response Analyses for Glofitamab in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R NHL): Confirmation of Efficacy and CRS Mitigation in Patients with Step-up Dosing

Synthesis and X-ray Crystal Structure of trans,cis-[Pt(OAc)2I2(en)]: A Novel Type of Cisplatin Analog That Can Be Photolyzed by Visible Light to DNA-Binding and Cytotoxic Species in Vitro

Surprising Reactions of Iodo Pt(IV) and Pt(II) Complexes with Human Albumin: Detection of Cys34 Sulfenic Acid

Population Pharmacokinetics and Novel Exposure-Response Analyses to Inform Optimal Biologic Dose Selection for CD20-TCB, a T-Cell-Engaging Bispecific Antibody, in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

cis-[PtCl2(NH3){2-(2-hydroxyethyl)pyridine}] − an Analogue of the Anticancer Drug AMD473: Unusual Hydrolysis Rates and pKa Values for the Diaqua Adduct

Electron-Transfer-Driven Trans-Ligand Labilization: A Novel Activation Mechanism for Pt(IV) Anticancer Complexes

CD20-TCB, a Novel T-Cell-Engaging Bispecific Antibody, Induces T-Cell-Mediated Killing in Relapsed or Refractory Non-Hodgkin Lymphoma: Biomarker Results From a Phase I Dose-Escalation Trial

Effect of thiols exported by cancer cells on the stability and growth-inhibitory activity of Pt(IV) complexes

[1H, 15N] NMR Studies of the Platination of Phosphorothioate Nucleotides − Monofunctional Sulfur Adducts versus Macrochelation

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