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Src activation regulates anoikis in human colon tumor cell lines

Oncogene, 2002-11, Vol.21 (51), p.7797-7807

2002

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4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4896-4911

2006

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A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants

Clinical cancer research, 2003-04, Vol.9 (4), p.1267-1273

2003

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A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Science (American Association for the Advancement of Science), 1994-08, Vol.265 (5175), p.1093-1095

1994

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Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Biochemical pharmacology, 2000-10, Vol.60 (7), p.885-898

2000

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Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Molecular cancer therapeutics, 2009-01, Vol.8 (1), p.45-54

2009

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Modulation of Histone Acetylation by [4-(Acetylamino)-N-(2-Amino-phenyl) Benzamide] in HCT-8 Colon Carcinoma

Molecular cancer therapeutics, 2003-04, Vol.2 (4), p.401

2003

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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5457-5465

1998

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Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest

Cancer research (Chicago, Ill.), 1999-12, Vol.59 (24), p.6145-6152

1999

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Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2373-2382

1999

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Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.267-276

1996

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Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes

The Journal of biological chemistry, 2002-04, Vol.277 (14), p.12318-12323

2002

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Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

The Journal of biological chemistry, 1998-06, Vol.273 (23), p.14468-14475

1998

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Synthesis, Structural Characterization, and Antitumor Properties of a Novel Class of Large-Ring Platinum(II) Chelate Complexes Incorporating the cis-1,4-Diaminocyclohexane Ligand in a Unique Locked Boat Conformation

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2630-2636

1994

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Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4- c]carbazole-1,3(2 H,6 H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

European journal of medicinal chemistry, 2008-06, Vol.43 (6), p.1276-1296

2008

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Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1996-02, Vol.39 (4), p.918-928

1996

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2296-2303

1997

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Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups

Journal of medicinal chemistry, 1992-11, Vol.35 (24), p.4526-4532

1992

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Inhibitors of tyrosine kinase

Current opinion in oncology, 1997-11, Vol.9 (6), p.562-568

1997

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377

1998

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Tyrosine kinase inhibitors. 7. 7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3780-3788

1995

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Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2'-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide)

Journal of medicinal chemistry, 1994-06, Vol.37 (13), p.2033-2042

1994

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Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids)

Journal of medicinal chemistry, 1993-08, Vol.36 (17), p.2459-2469

1993

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3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4200-4211

2000

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Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.413-426

1997

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Src activation regulates anoikis in human colon tumor cell lines

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Modulation of Histone Acetylation by [4-(Acetylamino)-N-(2-Amino-phenyl) Benzamide] in HCT-8 Colon Carcinoma

Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest

Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

Synthesis, Structural Characterization, and Antitumor Properties of a Novel Class of Large-Ring Platinum(II) Chelate Complexes Incorporating the cis-1,4-Diaminocyclohexane Ligand in a Unique Locked Boat Conformation

Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4- c]carbazole-1,3(2 H,6 H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups

Inhibitors of tyrosine kinase

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Tyrosine kinase inhibitors. 7. 7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2'-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide)

Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids)

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

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