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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

The Journal of clinical investigation, 2008-09, Vol.118 (9), p.3065-3074

2008

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Mitochondrial Complex I Activity Is Required for Maximal Autophagy

Cell reports (Cambridge), 2018-08, Vol.24 (9), p.2404-2417.e8

2018

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Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (9), p.3791-3796

2011

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]

Nature, 2004-09, Vol.431 (7005), p.200-205

2004

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Science (American Association for the Advancement of Science), 2009-10, Vol.326 (5949), p.140-144

2009

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Hypothalamic mTOR Signaling Regulates Food Intake

Science (American Association for the Advancement of Science), 2006-05, Vol.312 (5775), p.927-930

2006

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Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes

Molecular cell, 2017-07, Vol.67 (1), p.55-70.e4

2017

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Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection

Food and chemical toxicology, 2015-06, Vol.80, p.298-309

2015

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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

The Journal of cell biology, 2009-12, Vol.187 (6), p.859-874

2009

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34

Cell metabolism, 2008-05, Vol.7 (5), p.456-465

2008

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S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis

Molecular cell, 2016-05, Vol.62 (3), p.443-452

2016

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Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

PloS one, 2013-01, Vol.8 (1), p.e54221-e54221

2013

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S6K1 Plays a Critical Role in Early Adipocyte Differentiation

Developmental cell, 2010-05, Vol.18 (5), p.763-774

2010

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S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Molecular and Cellular Biology, 2004-04, Vol.24 (8), p.3112-3124

2004

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Molecular cell, 2003-06, Vol.11 (6), p.1457-1466

2003

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Mammalian TOR: A Homeostatic ATP Sensor

Science (American Association for the Advancement of Science), 2001-11, Vol.294 (5544), p.1102-1105

2001

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S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3

Nature immunology, 2016-05, Vol.17 (5), p.514-522

2016

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hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

Current opinion in cell biology, 2007-04, Vol.19 (2), p.135-141

2007

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A liaison between mTOR signaling, ribosome biogenesis and cancer

Biochimica et biophysica acta, 2015-07, Vol.1849 (7), p.812-820

2015

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Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

Molecular and Cellular Biology, 2004-11, Vol.24 (21), p.9508-9516

2004

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Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

BioEssays, 2002-01, Vol.24 (1), p.65-71

2002

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Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (4), p.1576-1581

2010

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mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma

Science translational medicine, 2012-06, Vol.4 (139), p.139ra84

2012

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V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

Oncotarget, 2015-09, Vol.6 (29), p.28057-28070

2015

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S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy

American Journal of Physiology - Renal Physiology, 2009-09, Vol.297 (3), p.F585-F593

2009

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Mitochondrial Complex I Activity Is Required for Maximal Autophagy

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Hypothalamic mTOR Signaling Regulates Food Intake

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

S6K1 Plays a Critical Role in Early Adipocyte Differentiation

S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Mammalian TOR: A Homeostatic ATP Sensor

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

A liaison between mTOR signaling, ribosome biogenesis and cancer

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy

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