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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Journal of the American Chemical Society, 2010-08, Vol.132 (31), p.10842-10846

2010

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HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease

Nature medicine, 2011-08, Vol.17 (8), p.968-974

2011

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Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9891-9899

2012

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HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease

Brain (London, England : 1878), 2018-03, Vol.141 (3), p.673-687

2018

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Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2109-2118

2009

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Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Nature communications, 2013-12, Vol.4 (1), Article 2907

2013

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Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

Clinical cancer research, 2019-11, Vol.25 (21), p.6452-6462

2019

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Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function

Scientific reports, 2017-08, Vol.7 (1), p.8626-11, Article 8626

2017

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Epigenetic Regulation of Autophagy by the Methyltransferase G9a

Molecular and Cellular Biology, 2013-10, Vol.33 (20), p.3983-3993

2013

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Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

Molecular and Cellular Biology, 2011-05, Vol.31 (10), p.2066-2078

2011

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Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor

ACS medicinal chemistry letters, 2020-05, Vol.11 (5), p.706-712

2020

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Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.4093-4103

2013

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Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4370-4373

2008

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HDAC6 is a target for protection and regeneration following injury in the nervous system

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (46), p.19599-19604

2009

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Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4810-4840

2021

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A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Frontiers in cellular neuroscience, 2014-03, Vol.8, p.68-68

2014

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Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

ChemMedChem, 2016-01, Vol.11 (1), p.15-21

2016

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The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

Journal of neuroscience research, 2009-02, Vol.87 (2), p.440-451

2009

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Synthesis and Evaluation of Technetium-99m- and Rhenium-Labeled Inhibitors of the Prostate-Specific Membrane Antigen (PSMA)

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4504-4517

2008

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Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

International journal of molecular sciences, 2019-04, Vol.20 (9), p.2112

2019

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A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019)

Expert opinion on therapeutic patents, 2020-02, Vol.30 (2), p.121-136

2020

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Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

ACS chemical neuroscience, 2019-03, Vol.10 (3), p.1679-1695

2019

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Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.285-296

2014

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N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[18F]Fluorobenzyl-l-Cysteine, [18F]DCFBC: A New Imaging Probe for Prostate Cancer

Clinical cancer research, 2008-05, Vol.14 (10), p.3036-3043

2008

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Therapeutic Effects of PKC Activators in Alzheimer's Disease Transgenic Mice

Proceedings of the National Academy of Sciences - PNAS, 2004-07, Vol.101 (30), p.11141-11146

2004

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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease

Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease

Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

HDAC6 is a target for protection and regeneration following injury in the nervous system

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

Synthesis and Evaluation of Technetium-99m- and Rhenium-Labeled Inhibitors of the Prostate-Specific Membrane Antigen (PSMA)

Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019)

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer

N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[18F]Fluorobenzyl-l-Cysteine, [18F]DCFBC: A New Imaging Probe for Prostate Cancer

Therapeutic Effects of PKC Activators in Alzheimer's Disease Transgenic Mice

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