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Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

ChemMedChem, 2016-01, Vol.11 (1), p.15-21

2016

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A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019)

Expert opinion on therapeutic patents, 2020-02, Vol.30 (2), p.121-136

2020

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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Journal of the American Chemical Society, 2010-08, Vol.132 (31), p.10842-10846

2010

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Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6232-6247

2016

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HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

Nature medicine, 2011-08, Vol.17 (8), p.968-974

2011

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Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9891-9899

2012

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HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease

Brain (London, England : 1878), 2018-03, Vol.141 (3), p.673-687

2018

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Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors

European journal of medicinal chemistry, 2021-01, Vol.209, p.112887-112887, Article 112887

2021

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Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2109-2118

2009

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Chemical origins of isoform selectivity in histone deacetylase inhibitors

Current pharmaceutical design, 2008-02, Vol.14 (6), p.505-528

2008

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Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Nature communications, 2013-12, Vol.4 (1), Article 2907

2013

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Epigenetic Regulation of Autophagy by the Methyltransferase G9a

Molecular and Cellular Biology, 2013-10, Vol.33 (20), p.3983-3993

2013

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Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

Clinical cancer research, 2019-11, Vol.25 (21), p.6452-6462

2019

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Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function

Scientific reports, 2017-08, Vol.7 (1), p.8626-11, Article 8626

2017

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A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Frontiers in cellular neuroscience, 2014-03, Vol.8, p.68-68

2014

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Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

Molecular and Cellular Biology, 2011-05, Vol.31 (10), p.2066-2078

2011

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Development of Small Molecules that Specifically Inhibit the D‑loop Activity of RAD51

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4511-4525

2016

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Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor

ACS medicinal chemistry letters, 2020-05, Vol.11 (5), p.706-712

2020

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Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models

Journal of medicinal chemistry, 2019-09, Vol.62 (18), p.8557-8577

2019

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Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.4093-4103

2013

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Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Nature communications, 2013-12, Vol.4 (1), p.2907-2907

2013

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Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus

Antimicrobial agents and chemotherapy, 2020-04, Vol.64 (5), p.AAC.02548-19

2020

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Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4370-4373

2008

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HDAC6 is a target for protection and regeneration following injury in the nervous system

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (46), p.19599-19604

2009

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Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4810-4840

2021

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Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019)

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease

Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors

Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

Chemical origins of isoform selectivity in histone deacetylase inhibitors

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

Development of Small Molecules that Specifically Inhibit the D‑loop Activity of RAD51

Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

HDAC6 is a target for protection and regeneration following injury in the nervous system

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model

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