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The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

Science (American Association for the Advancement of Science), 2011-08, Vol.333 (6044), p.883-885

2011

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High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1

International journal of molecular sciences, 2023-07, Vol.24 (13), p.11197

2023

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Kinesins and cancer

Nature reviews. Cancer, 2012-08, Vol.12 (8), p.527-539

2012

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Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

International journal of molecular sciences, 2020-10, Vol.21 (19), p.7375

2020

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Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH

Scientific reports, 2023-09, Vol.13 (1), p.16281-16281, Article 16281

2023

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Motor-dependent microtubule disassembly driven by tubulin tyrosination

The Journal of cell biology, 2009-06, Vol.185 (7), p.1159-1166

2009

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Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

eLife, 2022-11, Vol.11

2022

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Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching

The Journal of neuroscience, 2010-11, Vol.30 (44), p.14896-14906

2010

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Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13649

2023

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Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5676-5683

2010

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S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression

The Journal of biological chemistry, 2006-06, Vol.281 (26), p.17559-17569

2006

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Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

eLife, 2023-12, Vol.12

2023

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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

Molecular cancer therapeutics, 2019-12, Vol.18 (12), p.2394-2406

2019

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New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

Bioorganic & medicinal chemistry, 2016-02, Vol.24 (4), p.721-734

2016

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Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics

Science advances, 2023-03, Vol.9 (13), p.eadf3021-eadf3021

2023

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Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6317-6329

2013

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“Snapshots” of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5

The Journal of biological chemistry, 2013-06, Vol.288 (25), p.18588-18598

2013

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An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

Biochemical journal, 2009-12, Vol.425 (1), p.55-61

2009

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Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin‐Specific MKLP‐2 Inhibitor

Angewandte Chemie (International ed.), 2010-10, Vol.49 (44), p.8228-8231

2010

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Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation

Computational and structural biotechnology journal, 2021-01, Vol.19, p.2726-2741

2021

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In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities

Molecular cancer therapeutics, 2004-09, Vol.3 (9), p.1079-1090

2004

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Structure of Human Eg5 in Complex with a New Monastrol-based Inhibitor Bound in the R Configuration

The Journal of biological chemistry, 2007-03, Vol.282 (13), p.9740-9747

2007

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Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Acta crystallographica. Section D, Biological crystallography., 2013-09, Vol.69 (9), p.1780-1788

2013

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Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Biology open, 2019, Vol.8 (1)

2019

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Crystal Structure of the Motor Domain of the Human Kinetochore Protein CENP-E

Journal of molecular biology, 2004-07, Vol.340 (5), p.1107-1116

2004

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The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1

Kinesins and cancer

Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH

Motor-dependent microtubule disassembly driven by tubulin tyrosination

Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching

Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering

Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol

S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics

Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism

“Snapshots” of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin‐Specific MKLP‐2 Inhibitor

Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities

Structure of Human Eg5 in Complex with a New Monastrol-based Inhibitor Bound in the R Configuration

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Crystal Structure of the Motor Domain of the Human Kinetochore Protein CENP-E

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