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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics

PloS one, 2023-03, Vol.18 (3), p.e0282166-e0282166

2023

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Organic modification of layered zirconium phosphate/phosphonate for controlled release of therapeutic inorganic ions

Science and technology of advanced materials, 2021-12, Vol.22 (1), p.1000-1012

2021

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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia

Haematologica (Roma), 2022-06, Vol.107 (6), p.1311-1322

2022

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Responses to the Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines

Cancers, 2018-04, Vol.10 (4), p.127

2018

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ONO-7018, a First-in-Class MALT1 Inhibitor, Provides Novel Therapeutic Strategies for B Cell Malignancies: Overcoming BTK Inhibitor Acquired Resistance and Enhancing the Antitumor Effect of BTK Inhibitors

Blood, 2023-11, Vol.142 (Supplement 1), p.5779-5779

2023

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ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR -Mutated Non-Small Cell Lung Cancer

Clinical cancer research, 2020-05, Vol.26 (9), p.2244-2256

2020

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Triple combination therapy comprising osimertinib, an AXL inhibitor, and an FGFR inhibitor improves the efficacy of EGFR-mutated non-small cell lung cancer

Cancer letters, 2024-08, Vol.598, p.217124, Article 217124

2024

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Abstract 3727: Plasma inhibitory activity (PIA) is a possible pharmacodynamic marker for clinical development of a next generation pan-TRK inhibitor, ONO-5390556

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3727-3727

2017

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Pharmacokinetic-Pharmacodynamic-Efficacy Modeling of ONO-7579, a Novel Pan–Tropomyosin Receptor Kinase Inhibitor, in a Murine Xenograft Tumor Model

The Journal of pharmacology and experimental therapeutics, 2020-06, Vol.373 (3), p.361-369

2020

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Abstract 2954A: A potent and selective TRK inhibitor ONO-5390556, shows potent antitumor activity against both TRK-rearranged cancers and the resistant mutants

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2954-2954A

2016

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Anti-tumor efficacy study of the Bruton's tyrosine kinase (BTK) inhibitor, ONO/GS-4059, in combination with the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) demonstrates superior in vivo efficacy compared to ONO/GS-4059 in combination with rituximab

Leukemia & lymphoma, 2017-03, Vol.58 (3), p.699-707

2017

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Abstract 788: A novel, potent and selective pan-Trk inhibitor ONO-5390556, demonstrates therapeutic efficacy in cancer cells harboring the TrkA rearrangement

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.788-788

2015

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Abstract 1883: A novel Axl and Mertk dual inhibitor ONO-7475: A new therapeutic agent for the treatment of FLT3-ITD and -wild-type acute myeloid leukemia (AML) overexpressing

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1883-1883

2018

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AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Blood, 2019-11, Vol.134 (Supplement_1), p.2550-2550

2019

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Abstract 2452: ONO-4059, a novel oral Bruton's tyrosine kinase (Btk) inhibitor that demonstrates potent pharmacodynamic activity through Phosphorylated Btk (P-Btk) inhibition, in addition to effective anti-tumour activity in a TMD-8 (DLBCL) xenograft model

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2452-2452

2013

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Abstract 857: Development of a Bruton's tyrosine kinase (Btk) inhibitor - ONO-WG-307, a potential treatment for B-cell malignancies

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.857-857

2012

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Development of a Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-WG-307: Efficacy in ABC-DLBCL Xenograft Model – Potential Treatment for B-Cell Malignancies

Blood, 2011-11, Vol.118 (21), p.3731-3731

2011

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Precise Analysis of Thermal Volume Expansion of Crystal Lattice for Fully Aromatic Crystalline Polyimides by X‑ray Diffraction Method: Relationship between Molecular Structure and Linear/Volumetric Thermal Expansion

Macromolecules, 2017-03, Vol.50 (5), p.2112-2123

2017

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A label-free, direct solid-phase fluorimetric analysis of ochratoxin A in agricultural products with monoclonal antibody-immobilized monolith

Food chemistry, 2021-06, Vol.346, p.128736, Article 128736

2021

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新開発マグネシウム合金板材を適用した自動車用フロントフード部材の開発

軽金属, 2023/04/15, Vol.73(4), pp.168-174

2023

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Correction to Precise Analysis of Thermal Volume Expansion of Crystal Lattice for Fully Aromatic Crystalline Polyimides by X‑ray Diffraction Method: Relationship between Molecular Structure and Linear/Volumetric Thermal Expansion

Macromolecules, 2017-03, Vol.50 (6), p.2599-2600

2017

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Research for application of newly-developed magnesium alloy sheet to front hood of automobiles

Journal of Japan Institute of Light Metals, 2023/04/15, Vol.73(4), pp.168-174

2023

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Sustainability of Digital Transformation (DX), Institutional Research (IR), and Information and Communication Technology (ICT) in Higher Education Based on Eduinformatics

Intelligent Sustainable Systems, 2023, Vol.578, p.565-572

2023

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A New Concept of ICT on Eduinformatics in Higher Education

Proceedings of Sixth International Congress on Information and Communication Technology, 2021, Vol.235, p.693-700

2021

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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics

Organic modification of layered zirconium phosphate/phosphonate for controlled release of therapeutic inorganic ions

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia

Responses to the Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines

ONO-7018, a First-in-Class MALT1 Inhibitor, Provides Novel Therapeutic Strategies for B Cell Malignancies: Overcoming BTK Inhibitor Acquired Resistance and Enhancing the Antitumor Effect of BTK Inhibitors

ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR -Mutated Non-Small Cell Lung Cancer

Triple combination therapy comprising osimertinib, an AXL inhibitor, and an FGFR inhibitor improves the efficacy of EGFR-mutated non-small cell lung cancer

Abstract 3727: Plasma inhibitory activity (PIA) is a possible pharmacodynamic marker for clinical development of a next generation pan-TRK inhibitor, ONO-5390556

Pharmacokinetic-Pharmacodynamic-Efficacy Modeling of ONO-7579, a Novel Pan–Tropomyosin Receptor Kinase Inhibitor, in a Murine Xenograft Tumor Model

Abstract 2954A: A potent and selective TRK inhibitor ONO-5390556, shows potent antitumor activity against both TRK-rearranged cancers and the resistant mutants

Anti-tumor efficacy study of the Bruton's tyrosine kinase (BTK) inhibitor, ONO/GS-4059, in combination with the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) demonstrates superior in vivo efficacy compared to ONO/GS-4059 in combination with rituximab

Abstract 788: A novel, potent and selective pan-Trk inhibitor ONO-5390556, demonstrates therapeutic efficacy in cancer cells harboring the TrkA rearrangement

Abstract 1883: A novel Axl and Mertk dual inhibitor ONO-7475: A new therapeutic agent for the treatment of FLT3-ITD and -wild-type acute myeloid leukemia (AML) overexpressing

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Abstract 2452: ONO-4059, a novel oral Bruton's tyrosine kinase (Btk) inhibitor that demonstrates potent pharmacodynamic activity through Phosphorylated Btk (P-Btk) inhibition, in addition to effective anti-tumour activity in a TMD-8 (DLBCL) xenograft model

Abstract 857: Development of a Bruton's tyrosine kinase (Btk) inhibitor - ONO-WG-307, a potential treatment for B-cell malignancies

Development of a Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-WG-307: Efficacy in ABC-DLBCL Xenograft Model – Potential Treatment for B-Cell Malignancies

Precise Analysis of Thermal Volume Expansion of Crystal Lattice for Fully Aromatic Crystalline Polyimides by X‑ray Diffraction Method: Relationship between Molecular Structure and Linear/Volumetric Thermal Expansion

A label-free, direct solid-phase fluorimetric analysis of ochratoxin A in agricultural products with monoclonal antibody-immobilized monolith

新開発マグネシウム合金板材を適用した自動車用フロントフード部材の開発

Correction to Precise Analysis of Thermal Volume Expansion of Crystal Lattice for Fully Aromatic Crystalline Polyimides by X‑ray Diffraction Method: Relationship between Molecular Structure and Linear/Volumetric Thermal Expansion

Research for application of newly-developed magnesium alloy sheet to front hood of automobiles

Sustainability of Digital Transformation (DX), Institutional Research (IR), and Information and Communication Technology (ICT) in Higher Education Based on Eduinformatics

A New Concept of ICT on Eduinformatics in Higher Education

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