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Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction

Cancer cell, 2015-02, Vol.27 (2), p.240-256

2015

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Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Cancer research (Chicago, Ill.), 2014, Vol.74 (1), p.153-161

2014

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Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

Cancer discovery, 2014-01, Vol.4 (1), p.80-93

2014

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BRAF Inhibitor Vemurafenib Improves the Antitumor Activity of Adoptive Cell Immunotherapy

Cancer research (Chicago, Ill.), 2012-08, Vol.72 (16), p.3928-3937

2012

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Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

The Journal of clinical investigation, 2013-03, Vol.123 (3), p.1371-1381

2013

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CTLA4 blockade increases Th17 cells in patients with metastatic melanoma

Journal of translational medicine, 2009-05, Vol.7 (35), p.35-35, Article 35

2009

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CTLA4 Blockade Induces Frequent Tumor Infiltration by Activated Lymphocytes Regardless of Clinical Responses in Humans

Clinical cancer research, 2011-06, Vol.17 (12), p.4101-4109

2011

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Human antigen-specific regulatory T cells generated by T cell receptor gene transfer

PloS one, 2010-07, Vol.5 (7), p.e11726-e11726

2010

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Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.E1408-E1416

2011

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Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer

Journal for immunotherapy of cancer, 2019-06, Vol.7 (1), p.156-156, Article 156

2019

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WHSC1/NSD2 regulates immune infiltration in prostate cancer

Journal for immunotherapy of cancer, 2021-02, Vol.9 (2), p.e001374

2021

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Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

Molecular cancer, 2012-04, Vol.11 (1), p.22-22, Article 22

2012

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Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (32), p.14286-14291

2010

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A rare population of tumor antigen-specific CD4 + CD8 + double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells

Journal for immunotherapy of cancer, 2019-01, Vol.7 (1), p.7-7, Article 7

2019

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Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma

Science translational medicine, 2015-03, Vol.7 (279), p.279ra41

2015

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Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (52), p.13679-13684

2017

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

Nature (London), 2010-12, Vol.468 (7326), p.973-977

2010

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Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance

Nature communications, 2012-03, Vol.3 (1), p.724-724, Article 724

2012

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CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

Clinical cancer research, 2014-05, Vol.20 (9), p.2424-2432

2014

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Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

Nature communications, 2012-03, Vol.3, p.724

2012

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Measurement and Quantitative Characterization of Whole-Body Pharmacokinetics of Exogenously Administered T Cells in Mice

The Journal of pharmacology and experimental therapeutics, 2019-03, Vol.368 (3), p.503-513

2019

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Natural killer T cells in advanced melanoma patients treated with tremelimumab

PloS one, 2013-10, Vol.8 (10), p.e76829-e76829

2013

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A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

Nature medicine, 2011-06, Vol.17 (6), p.738-743

2011

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Active Immunotherapy of Cancer

Immunological investigations, 2015-11, Vol.44 (8), p.817-836

2015

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Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway

Journal of translational medicine, 2011-11, Vol.9 (1), p.192-192, Article 192

2011

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Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

BRAF Inhibitor Vemurafenib Improves the Antitumor Activity of Adoptive Cell Immunotherapy

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

CTLA4 blockade increases Th17 cells in patients with metastatic melanoma

CTLA4 Blockade Induces Frequent Tumor Infiltration by Activated Lymphocytes Regardless of Clinical Responses in Humans

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer

WHSC1/NSD2 regulates immune infiltration in prostate cancer

Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses

A rare population of tumor antigen-specific CD4 + CD8 + double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance

CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

Measurement and Quantitative Characterization of Whole-Body Pharmacokinetics of Exogenously Administered T Cells in Mice

Natural killer T cells in advanced melanoma patients treated with tremelimumab

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

Active Immunotherapy of Cancer

Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway

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