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No Dose Adjustment for Isavuconazole Based on Age or Sex

Antimicrobial agents and chemotherapy, 2019-06, Vol.63 (6)

2019

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Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi

Antimicrobial agents and chemotherapy, 2017-12, Vol.61 (12)

2017

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Phase I trial to investigate the effect of renal impairment on isavuconazole pharmacokinetics

European journal of clinical pharmacology, 2017-06, Vol.73 (6), p.669-678

2017

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Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies

Advances in therapy, 2017-12, Vol.34 (12), p.2625-2637

2017

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Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects

Clinical pharmacology in drug development, 2017-01, Vol.6 (1), p.66-75

2017

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The Influence of Hepatic and Renal Impairment on the Pharmacokinetics of a Treatment for Herpes Zoster, Amenamevir (ASP2151): Phase 1, Open-Label, Single-Dose, Parallel-Group Studies

Advances in therapy, 2017-12, Vol.34 (12), p.2612-2624

2017

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Effects of Food Intake on the Pharmacokinetic Properties of Mirabegron Oral Controlled-Absorption System: A Single-Dose, Randomized, Crossover Study in Healthy Adults

Clinical therapeutics, 2013-03, Vol.35 (3), p.333-341

2013

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QTc changes after meal intake: Sex differences and correlates

Journal of electrocardiology, 2014-11, Vol.47 (6), p.856-862

2014

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Reproducibility of QTc interval changes after meal intake

Journal of electrocardiology, 2015-03, Vol.48 (2), p.194-202

2015

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Importance of subject-specific QT/RR curvatures in the design of individual heart rate corrections of the QT interval

Journal of electrocardiology, 2012-11, Vol.45 (6), p.571-581

2012

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Population Pharmacokinetics of Isavuconazole from Phase 1 and Phase 3 (SECURE) Trials in Adults and Target Attainment in Patients with Invasive Infections Due to Aspergillus and Other Filamentous Fungi

Antimicrobial agents and chemotherapy, 2016-09, Vol.60 (9), p.5483-5491

2016

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Role of Cytochrome P450 Isoenzymes 3A and 2D6 in the In Vivo Metabolism of Mirabegron, a β3-Adrenoceptor Agonist

Clinical drug investigation, 2013-06, Vol.33 (6), p.429-440

2013

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Relationship of QT interval variability to heart rate and RR interval variability

Journal of electrocardiology, 2013-11, Vol.46 (6), p.591-596

2013

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Are QTc interval changes after meal intake a reasonable method to prove assay sensitivity in thorough QT studies?

Journal of electrocardiology, 2015-03, Vol.48 (2), p.276-277

2015

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Have individual QT/RR curvatures value in QT correction?

Journal of electrocardiology, 2014-05, Vol.47 (3), p.386-391

2014

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Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH

International journal of clinical pharmacology and therapeutics, 2016-08, Vol.54 (8), p.572-580

2016

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Time-dependent inhibitory effects of (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0(4.9)]octacos-18-ene-2,3,10,16-tetrone (FK1706), a novel nonimmunosuppressive immunophilin ligand, on CYP3A4/5 activity in humans in vivo and in vitro

Drug metabolism and disposition, 2010-02, Vol.38 (2), p.249-259

2010

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963 Influence of PPI Run-in, pH Monitoring and Nutrient Tolerance On Efficacy Outcomes of Acotiamide Hydrochloride (YM443), a Novel Acetylcholine Esterase Inhibitor, in Functional Dyspepsia

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-143-A-143

2008

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1053 A Novel Acetylcholine Esterase Inhibitor Acotiamide Hydrochloride (YM443) in Functional Dyspepsia: Efficacy in a Randomized, Double-Blind, Placebo-Controlled Dose Ranging Trial

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-157-A-158

2008

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QT/RR curvatures in healthy subjects: sex differences and covariates

American journal of physiology. Heart and circulatory physiology, 2013-12, Vol.305 (12), p.H1798-H1806

2013

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Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults

Clinical pharmacology in drug development, 2017-01, Vol.6 (1), p.44-53

2017

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Pharmacokinetic Assessment of Drug‐Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults

Clinical pharmacology in drug development, 2017-01, Vol.6 (1), p.76-85

2017

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Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus

Diabetes technology & therapeutics, 2011-12, Vol.13 (12), p.1219-1227

2011

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Optimization of the operating conditions of a lab scale Aljet mill using lactose and sucrose: a technical note

AAPS PharmSciTech, 2003, Vol.4 (2), p.E27-146

2003

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Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

Clinical pharmacology in drug development, 2017-01, Vol.6 (1), p.86-92

2017

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No Dose Adjustment for Isavuconazole Based on Age or Sex

Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi

Phase I trial to investigate the effect of renal impairment on isavuconazole pharmacokinetics

Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies

Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects

The Influence of Hepatic and Renal Impairment on the Pharmacokinetics of a Treatment for Herpes Zoster, Amenamevir (ASP2151): Phase 1, Open-Label, Single-Dose, Parallel-Group Studies

Effects of Food Intake on the Pharmacokinetic Properties of Mirabegron Oral Controlled-Absorption System: A Single-Dose, Randomized, Crossover Study in Healthy Adults

QTc changes after meal intake: Sex differences and correlates

Reproducibility of QTc interval changes after meal intake

Importance of subject-specific QT/RR curvatures in the design of individual heart rate corrections of the QT interval

Population Pharmacokinetics of Isavuconazole from Phase 1 and Phase 3 (SECURE) Trials in Adults and Target Attainment in Patients with Invasive Infections Due to Aspergillus and Other Filamentous Fungi

Role of Cytochrome P450 Isoenzymes 3A and 2D6 in the In Vivo Metabolism of Mirabegron, a β3-Adrenoceptor Agonist

Relationship of QT interval variability to heart rate and RR interval variability

Are QTc interval changes after meal intake a reasonable method to prove assay sensitivity in thorough QT studies?

Have individual QT/RR curvatures value in QT correction?

Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH

963 Influence of PPI Run-in, pH Monitoring and Nutrient Tolerance On Efficacy Outcomes of Acotiamide Hydrochloride (YM443), a Novel Acetylcholine Esterase Inhibitor, in Functional Dyspepsia

1053 A Novel Acetylcholine Esterase Inhibitor Acotiamide Hydrochloride (YM443) in Functional Dyspepsia: Efficacy in a Randomized, Double-Blind, Placebo-Controlled Dose Ranging Trial

QT/RR curvatures in healthy subjects: sex differences and covariates

Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults

Pharmacokinetic Assessment of Drug‐Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults

Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus

Optimization of the operating conditions of a lab scale Aljet mill using lactose and sucrose: a technical note

Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

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