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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system

Molecular pharmacology, 2010-12, Vol.78 (6), p.996-1003

2010

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The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

The Journal of pharmacology and experimental therapeutics, 2011-07, Vol.338 (1), p.345-352

2011

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5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7639-7646

2010

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Identification of a series of benzoxazoles as potent 5-HT6 ligands

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1115-1117

2009

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Pharmacological comparison of muscarinic ligands : Historical versus more recent muscarinic M1-preferring receptor agonists

European journal of pharmacology, 2009-03, Vol.605 (1-3), p.53-56

2009

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Distinct functional profiles of aripiprazole and olanzapine at RNA edited human 5-HT2C receptor isoforms

Biochemical pharmacology, 2006-02, Vol.71 (4), p.521-529

2006

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Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2983-2986

2010

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The role of transmembrane helix 5 in agonist binding to the human H3 receptor

The Journal of pharmacology and experimental therapeutics, 2002-05, Vol.301 (2), p.451-458

2002

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Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (1), p.650-662

2011

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Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2

Molecular pharmacology, 2005-10, Vol.68 (4), p.974-982

2005

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1-Sulfonylindazoles as potent and selective 5-HT6 ligands

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2413-2415

2009

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Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective α2A-adrenoceptor antagonism

The international journal of neuropsychopharmacology, 2010-10, Vol.13 (9), p.1193-1205

2010

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A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.3929-3931

2008

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Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5552-5555

2009

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Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3214-3216

2009

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Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4985-4988

2005

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Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride)

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.563

2004

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WAY‐855 (3‐amino‐tricyclo[2.2.1.02.6]heptane‐1,3‐dicarboxylic acid): a novel, EAAT2‐preferring, nonsubstrate inhibitor of high‐affinity glutamate uptake

British journal of pharmacology, 2003-11, Vol.140 (5), p.839-846

2003

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Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT 6 ligands

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3214-3216

2009

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Design, Synthesis, SAR, and Biological Evaluation of Highly Potent Benzimidazole-Spaced Phosphono-α-Amino Acid Competitive NMDA Antagonists of the AP-6 Type

Journal of medicinal chemistry, 2001-05, Vol.44 (10), p.1516-1529

2001

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Design and Synthesis of [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)- ethyl]phosphonic Acid (EAA-090), a Potent N-Methyl-d-aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral α-Amino Acid Bioisostere

Journal of medicinal chemistry, 1998-01, Vol.41 (2), p.236-246

1998

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Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

The Journal of pharmacology and experimental therapeutics, 2009-05, Vol.329 (2), p.459-468

2009

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The C-terminus of Gi family G-proteins as a determinant of 5-HT1A receptor coupling

Biochemical and biophysical research communications, 2002-06, Vol.294 (3), p.655-659

2002

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Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M 1-preferring receptor agonists

European journal of pharmacology, 2009-03, Vol.605 (1), p.53-56

2009

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Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine 2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl- N -3-pyridinylbenzo[1,2- b :4,5- b ′]di pyrrole-1(2 H )-carboxamide)

The Journal of pharmacology and experimental therapeutics, 2009-03, Vol.328 (3), p.766-776

2009

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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists

Identification of a series of benzoxazoles as potent 5-HT6 ligands

Pharmacological comparison of muscarinic ligands : Historical versus more recent muscarinic M1-preferring receptor agonists

Distinct functional profiles of aripiprazole and olanzapine at RNA edited human 5-HT2C receptor isoforms

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

The role of transmembrane helix 5 in agonist binding to the human H3 receptor

Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists

Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2

1-Sulfonylindazoles as potent and selective 5-HT6 ligands

Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective α2A-adrenoceptor antagonism

A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride)

WAY‐855 (3‐amino‐tricyclo[2.2.1.02.6]heptane‐1,3‐dicarboxylic acid): a novel, EAAT2‐preferring, nonsubstrate inhibitor of high‐affinity glutamate uptake

Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT 6 ligands

Design, Synthesis, SAR, and Biological Evaluation of Highly Potent Benzimidazole-Spaced Phosphono-α-Amino Acid Competitive NMDA Antagonists of the AP-6 Type

Design and Synthesis of [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)- ethyl]phosphonic Acid (EAA-090), a Potent N-Methyl-d-aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral α-Amino Acid Bioisostere

Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

The C-terminus of Gi family G-proteins as a determinant of 5-HT1A receptor coupling

Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M 1-preferring receptor agonists

Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine 2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl- N -3-pyridinylbenzo[1,2- b :4,5- b ′]di pyrrole-1(2 H )-carboxamide)

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