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Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules

Medicinal research reviews, 2020-03, Vol.40 (2), p.709-752

2020

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A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp

Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6173

2022

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Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies

ChemMedChem, 2020-03, Vol.15 (5), p.392-403

2020

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Balancing Antioxidant, Hypolipidemic and Anti-inflammatory Activity in a Single Agent: The Example of 2-Hydroxy-2-Substituted Morpholine, 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives as a Rational Therapeutic Approach against Atherosclerosis

Current medicinal chemistry, 2017-01, Vol.24 (12), p.1214

2017

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Effect of a new squalene synthase inhibitor on an ApoE−/− mouse model of atherosclerosis

Bioorganic & medicinal chemistry, 2023-07, Vol.90, p.117378-117378, Article 117378

2023

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New applications of squalene synthase inhibitors: Membrane cholesterol as a therapeutic target

Archiv der Pharmazie (Weinheim), 2020-09, Vol.353 (9), p.e2000085-n/a

2020

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Design of Improved Antidiabetic Drugs: A Journey from Single to Multitarget Agents

ChemMedChem, 2022-12, Vol.17 (23), p.e202200320-n/a

2022

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Design of Novel Potent Antihyperlipidemic Agents with Antioxidant/Anti-inflammatory Properties: Exploiting Phenothiazine’s Strong Antioxidant Activity

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2568-2581

2014

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Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

British journal of pharmacology, 2000-05, Vol.130 (1), p.1-12

2000

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Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution

Bioorganic & medicinal chemistry, 2015-11, Vol.23 (21), p.7015-7023

2015

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Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity

European journal of medicinal chemistry, 2017-09, Vol.138, p.748-760

2017

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Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.98-104

2019

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Novel Benzoxazine and Benzothiazine Derivatives as Multifunctional Antihyperlipidemic Agents

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5583-5591

2011

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EP2306 [2-(4-biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol, hydrobromide], a novel squalene synthase inhibitor, reduces atherosclerosis in the cholesterol-fed rabbit

The Journal of pharmacology and experimental therapeutics, 2007-12, Vol.323 (3), p.794-804

2007

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New Multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine Derivatives with Antioxidant, Antihyperlipidemic, and Antidiabetic Action

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3330-3338

2013

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Alkannin and Shikonin: Effect on Free Radical Processes and on Inflammation - A Preliminary Pharmacochemical Investigation

Archiv der Pharmazie (Weinheim), 2002-08, Vol.335 (6), p.262-266

2002

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Evaluation of two novel antioxidants with differential effects on curcumin-induced apoptosis in C2 skeletal myoblasts; involvement of JNKs

Bioorganic & medicinal chemistry, 2015-02, Vol.23 (3), p.390-400

2015

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Design of more potent squalene synthase inhibitors with multiple activities

Bioorganic & medicinal chemistry, 2010-11, Vol.18 (21), p.7402-7412

2010

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Antinociceptive properties of 1,8-Cineole and β-Pinene, from the essential oil of Eucalyptus camaldulensis leaves, in rodents

Planta medica, 2007-10, Vol.73 (12), p.1247-1254

2007

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Antinociceptive properties of 1,8-cineole and β-pinene, from the Essential oil of Eucalyptus camaldu lensis leaves, in rodents

Planta medica, 2007-10, Vol.73 (12), p.1247-1254

2007

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Lipid-Lowering (Hetero)Aromatic Tetrahydro-1,4-Oxazine Derivatives with Antioxidant and Squalene Synthase Inhibitory Activity

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5861-5865

2008

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Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties

Medicinal chemistry research, 2015, Vol.24 (4), p.1725-1732

2015

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Antioxidant Activity of Guaiazulene and Protection Against Paracetamol Hepatotoxicity in Rats

Journal of pharmacy and pharmacology, 1997-09, Vol.49 (9), p.938-942

1997

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Novel Compounds Designed as Antistress Agents

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.7315-7318

2009

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Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (14), p.3639-3643

2004

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Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp

Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies

Balancing Antioxidant, Hypolipidemic and Anti-inflammatory Activity in a Single Agent: The Example of 2-Hydroxy-2-Substituted Morpholine, 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives as a Rational Therapeutic Approach against Atherosclerosis

Effect of a new squalene synthase inhibitor on an ApoE−/− mouse model of atherosclerosis

New applications of squalene synthase inhibitors: Membrane cholesterol as a therapeutic target

Design of Improved Antidiabetic Drugs: A Journey from Single to Multitarget Agents

Design of Novel Potent Antihyperlipidemic Agents with Antioxidant/Anti-inflammatory Properties: Exploiting Phenothiazine’s Strong Antioxidant Activity

Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution

Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity

Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives

Novel Benzoxazine and Benzothiazine Derivatives as Multifunctional Antihyperlipidemic Agents

EP2306 [2-(4-biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol, hydrobromide], a novel squalene synthase inhibitor, reduces atherosclerosis in the cholesterol-fed rabbit

New Multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine Derivatives with Antioxidant, Antihyperlipidemic, and Antidiabetic Action

Alkannin and Shikonin: Effect on Free Radical Processes and on Inflammation - A Preliminary Pharmacochemical Investigation

Evaluation of two novel antioxidants with differential effects on curcumin-induced apoptosis in C2 skeletal myoblasts; involvement of JNKs

Design of more potent squalene synthase inhibitors with multiple activities

Antinociceptive properties of 1,8-Cineole and β-Pinene, from the essential oil of Eucalyptus camaldulensis leaves, in rodents

Antinociceptive properties of 1,8-cineole and β-pinene, from the Essential oil of Eucalyptus camaldu lensis leaves, in rodents

Lipid-Lowering (Hetero)Aromatic Tetrahydro-1,4-Oxazine Derivatives with Antioxidant and Squalene Synthase Inhibitory Activity

Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties

Antioxidant Activity of Guaiazulene and Protection Against Paracetamol Hepatotoxicity in Rats

Novel Compounds Designed as Antistress Agents

Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity

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