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Advances in the Enzymatic Reduction of Ketones

Accounts of chemical research, 2007-12, Vol.40 (12), p.1412-1419

2007

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CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

Journal of organic chemistry, 2012-03, Vol.77 (5), p.2299-2309

2012

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Green and sustainable metrics: Charting the course for green-by-design small molecule API synthesis

Current research in green and sustainable chemistry, 2022, Vol.5, p.100324, Article 100324

2022

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Biocatalytic Asymmetric Hydrogen Transfer Employing Rhodococcus ruber DSM 44541

Journal of organic chemistry, 2003-01, Vol.68 (2), p.402-406

2003

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Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions

Biotechnology and bioengineering, 2004-04, Vol.86 (1), p.55-62

2004

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Recent preparative applications of redox enzymes

Current opinion in chemical biology, 2019-04, Vol.49, p.105-112

2019

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Non-Racemic Halohydrins via Biocatalytic Hydrogen-Transfer Reduction of Halo-Ketones and One-Pot Cascade Reaction to Enantiopure Epoxides

Advanced synthesis & catalysis, 2005-11, Vol.347 (14), p.1827-1834

2005

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Resolution of 2,2-Disubstituted Epoxides via Biocatalytic Azidolysis

Organic letters, 2010-09, Vol.12 (17), p.3772-3775

2010

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Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction

Organic process research & development, 2022-05, Vol.26 (5), p.1405-1410

2022

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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1Process History and Development Strategy

Organic process research & development, 2024-02, Vol.28 (2), p.404-412

2024

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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5Chemoenzymatic Diastereoselective Fluorination/DKR

Organic process research & development, 2024-02, Vol.28 (2), p.441-450

2024

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Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12

ACS sustainable chemistry & engineering, 2022-04, Vol.10 (16), p.5148-5162

2022

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Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029

Organic process research & development, 2022-03, Vol.26 (3), p.648-656

2022

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Biocatalytic oxidative kinetic resolution of sec-alcohols: stereocontrol through substrate-modification

Tetrahedron: asymmetry, 2003-01, Vol.14 (2), p.275-280

2003

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Scalable Asymmetric Synthesis of MK-8998, a T‑Type Calcium Channel Antagonist

Journal of organic chemistry, 2022-02, Vol.87 (4), p.2120-2128

2022

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Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

Organic process research & development, 2014-01, Vol.18 (1), p.215-227

2014

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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan

Angewandte Chemie International Edition, 2024-03, Vol.63 (13), p.e202316133-n/a

International ed. in English, 2024

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Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction

Angewandte Chemie International Edition, 2018-06, Vol.57 (23), p.6863-6867

International ed. in English, 2018

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MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph

Tetrahedron: asymmetry, 2010, Vol.21 (13), p.1674-1681

2010

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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction

Organic letters, 2016-11, Vol.18 (22), p.5888-5891

2016

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Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

Organic process research & development, 2017-11, Vol.21 (11), p.1851-1858

2017

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Asymmetric bioreduction of α,β-unsaturated nitriles and ketones

Tetrahedron: asymmetry, 2008-06, Vol.19 (12), p.1403-1406

2008

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Biocatalytic Asymmetric Hydrogen Transfer

Angewandte Chemie (International ed.), 2002-03, Vol.41 (6), p.1014-1017

2002

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Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

Advanced synthesis & catalysis, 2016-03, Vol.358 (5), p.731-736

2016

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Preparative Asymmetric Synthesis of 4,4-Dimethoxytetrahydro-2H-pyran-3-ol with a Ketone Reductase and in Situ Cofactor Recycling using Glucose Dehydrogenase

Organic process research & development, 2008-07, Vol.12 (4), p.584-588

2008

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Advances in the Enzymatic Reduction of Ketones

CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

Green and sustainable metrics: Charting the course for green-by-design small molecule API synthesis

Biocatalytic Asymmetric Hydrogen Transfer Employing Rhodococcus ruber DSM 44541

Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions

Recent preparative applications of redox enzymes

Non-Racemic Halohydrins via Biocatalytic Hydrogen-Transfer Reduction of Halo-Ketones and One-Pot Cascade Reaction to Enantiopure Epoxides

Resolution of 2,2-Disubstituted Epoxides via Biocatalytic Azidolysis

Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1Process History and Development Strategy

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5Chemoenzymatic Diastereoselective Fluorination/DKR

Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12

Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029

Biocatalytic oxidative kinetic resolution of sec-alcohols: stereocontrol through substrate-modification

Scalable Asymmetric Synthesis of MK-8998, a T‑Type Calcium Channel Antagonist

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan

Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction

MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

Asymmetric bioreduction of α,β-unsaturated nitriles and ketones

Biocatalytic Asymmetric Hydrogen Transfer

Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

Preparative Asymmetric Synthesis of 4,4-Dimethoxytetrahydro-2H-pyran-3-ol with a Ketone Reductase and in Situ Cofactor Recycling using Glucose Dehydrogenase

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