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Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width

Journal of molecular and cellular cardiology, 2010-05, Vol.48 (5), p.817-823

2010

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Regulation of Connective Tissue Growth Factor Gene Expression and Fibrosis in Human Heart Failure

Journal of cardiac failure, 2013-04, Vol.19 (4), p.283-294

2013

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Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy

Cardiovascular research, 2011-12, Vol.92 (3), p.409-419

2011

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Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy

Journal of molecular and cellular cardiology, 2014-07, Vol.72, p.281-291

2014

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Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors

Toxicological sciences, 2024-03, Vol.198 (2), p.316-327

2024

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FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells

Arteriosclerosis, thrombosis, and vascular biology, 2010-11, Vol.30 (11), p.2226

2010

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Innovative approaches to cardiovascular safety pharmacology assessment

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107533, Article 107533

2024

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Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog

Journal of pharmacological and toxicological methods, 2024-03, Vol.126, p.107497-107497, Article 107497

2024

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Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107300-107300, Article 107300

2023

Volltextzugriff (PDF)

Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment

Journal of pharmacological and toxicological methods, 2022-09, Vol.117, p.107206-107206, Article 107206

2022

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Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration

Cardiovascular research, 2010-02, Vol.85 (3), p.571-581

2010

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Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.4252-4264

2013

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Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models

Journal of pharmacological and toxicological methods, 2023-03, Vol.120, p.107251-107251, Article 107251

2023

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Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Journal of pharmacological and toxicological methods, 2021-05, Vol.109, p.107066-107066, Article 107066

2021

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Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities

Journal of pharmacological and toxicological methods, 2021-11, Vol.112, p.107115-107115, Article 107115

2021

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Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy

Journal of molecular and cellular cardiology, 2015-12, Vol.89 (Pt B), p.214-222

2015

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Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

Comparative medicine, 2021-04, Vol.71 (2), p.133-140

2021

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Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107109-107109, Article 107109

2021

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The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs

Journal of pharmacological and toxicological methods, 2018-05, Vol.91, p.27-35

2018

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Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Journal of pharmacological and toxicological methods, 2020-05, Vol.103, p.106871, Article 106871

2020

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Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes

FEBS letters, 2007-09, Vol.581 (22), p.4241-4247

2007

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Signaling responses after exposure to 5α-dihydrotestosterone or 17β-estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes

Journal of applied physiology (1985), 2010-03, Vol.108 (3), p.686-696

2010

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Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes

Journal of molecular and cellular cardiology, 2008-12, Vol.45 (6), p.853-856

2008

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Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding

Arteriosclerosis, thrombosis, and vascular biology, 2011-11, Vol.31 (11), p.2432

2011

Volltextzugriff (PDF)

Drug-induced QT prolongation: Concordance of preclinical canine model in relation to clinical outcome

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106757, Article 106757

2020

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Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width

Regulation of Connective Tissue Growth Factor Gene Expression and Fibrosis in Human Heart Failure

Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy

Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy

Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors

FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells

Innovative approaches to cardiovascular safety pharmacology assessment

Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog

Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document

Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment

Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration

Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload

Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities

Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes

Signaling responses after exposure to 5α-dihydrotestosterone or 17β-estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes

Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes

Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding

Drug-induced QT prolongation: Concordance of preclinical canine model in relation to clinical outcome

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