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Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100964, Article 100964

2024

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Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A

Molecular pharmaceutics, 2018-05, Vol.15 (5), p.1979-1995

2018

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Molecular Modeling of Drug–Transporter Interactions—An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.818-835

2018

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A permeability‐ and perfusion‐based PBPK model for improved prediction of concentration‐time profiles

Clinical and translational science, 2022-08, Vol.15 (8), p.2035-2052

2022

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Using partition analysis as a facile method to derive net clearances

Clinical and translational science, 2022-08, Vol.15 (8), p.1867-1879

2022

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Models to predict unbound intracellular drug concentrations in the presence of transporters

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.865

2012

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Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts Are Correct

Drug metabolism and disposition, 2023-04, Vol.51 (4), p.532-542

2023

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Drug Distribution Part 2. Predicting Volume of Distribution from Plasma Protein Binding and Membrane Partitioning

Pharmaceutical research, 2017-03, Vol.34 (3), p.544-551

2017

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Commentary: nonspecific protein binding versus membrane partitioning: it is not just semantics

Drug metabolism and disposition, 2012-09, Vol.40 (9), p.1649

2012

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On the Nature of Physiologically-Based Pharmacokinetic Models –A Priori or A Posteriori? Mechanistic or Empirical?

Pharmaceutical research, 2017-03, Vol.34 (3), p.529-534

2017

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Drug Distribution. Part 1. Models to Predict Membrane Partitioning

Pharmaceutical research, 2017-03, Vol.34 (3), p.535-543

2017

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Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model

Drug metabolism and disposition, 2022-06, Vol.50 (6), p.750-761

2022

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Compartmental Models for Apical Efflux by P-glycoprotein: Part 2—A Theoretical Study on Transporter Kinetic Parameters

Pharmaceutical research, 2014-02, Vol.31 (2), p.335-346

2014

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Time-dependent enzyme inactivation: Numerical analyses of in vitro data and prediction of drug-drug interactions

Pharmacology & therapeutics (Oxford), 2020-02, Vol.206, p.107449-107449, Article 107449

2020

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A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate

Molecular pharmaceutics, 2024-07

2024

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Impact of Lipid Partitioning on the Design, Analysis, and Interpretation of Microsomal Time-Dependent Inactivation

Drug metabolism and disposition, 2019-07, Vol.47 (7), p.732-742

2019

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Concentration‐Time profiles of Glyburide in Rats: Predictions using a Continuous Absorption Model

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Numerical method analysis of the activation and time‐dependent inhibition of midazolam metabolism by ticlopidine

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Mathematical Modeling of In Vitro‐In Vivo Atypical Kinetics of Diazepam

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Continuous Intestinal Absorption Model Based on the Convection–Diffusion Equation

Molecular pharmaceutics, 2017-09, Vol.14 (9), p.3069-3086

2017

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Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1050-1060

2019

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A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats

Xenobiotica, 2020-05, Vol.50 (5), p.536-544

2020

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Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting

Xenobiotica, 2020-11, Vol.50 (11), p.1301-1310

2020

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Compartmental Models for Apical Efflux by P-glycoprotein: Part 2--A Theoretical Study on Transporter Kinetic Parametersr

Pharmaceutical research, 2014-02, Vol.31 (2), p.335

2014

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Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 2. Modeling of Experimental Data

Drug metabolism and disposition, 2021-12, Vol.49 (12), p.1100-1108

2021

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Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs

Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A

Molecular Modeling of Drug–Transporter Interactions—An International Transporter Consortium Perspective

A permeability‐ and perfusion‐based PBPK model for improved prediction of concentration‐time profiles

Using partition analysis as a facile method to derive net clearances

Models to predict unbound intracellular drug concentrations in the presence of transporters

Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts Are Correct

Drug Distribution Part 2. Predicting Volume of Distribution from Plasma Protein Binding and Membrane Partitioning

Commentary: nonspecific protein binding versus membrane partitioning: it is not just semantics

On the Nature of Physiologically-Based Pharmacokinetic Models –A Priori or A Posteriori? Mechanistic or Empirical?

Drug Distribution. Part 1. Models to Predict Membrane Partitioning

Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model

Compartmental Models for Apical Efflux by P-glycoprotein: Part 2—A Theoretical Study on Transporter Kinetic Parameters

Time-dependent enzyme inactivation: Numerical analyses of in vitro data and prediction of drug-drug interactions

A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate

Impact of Lipid Partitioning on the Design, Analysis, and Interpretation of Microsomal Time-Dependent Inactivation

Concentration‐Time profiles of Glyburide in Rats: Predictions using a Continuous Absorption Model

Numerical method analysis of the activation and time‐dependent inhibition of midazolam metabolism by ticlopidine

Mathematical Modeling of In Vitro‐In Vivo Atypical Kinetics of Diazepam

Continuous Intestinal Absorption Model Based on the Convection–Diffusion Equation

Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions

A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats

Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting

Compartmental Models for Apical Efflux by P-glycoprotein: Part 2--A Theoretical Study on Transporter Kinetic Parametersr

Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 2. Modeling of Experimental Data

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