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Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

Cell stem cell, 2016-01, Vol.18 (1), p.79-90

2016

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An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

Nature communications, 2019-05, Vol.10 (1), p.2139-14, Article 2139

2019

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SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis

The Journal of clinical investigation, 2022-12, Vol.132 (24), p.1-19

2022

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Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification

American journal of physiology. Renal physiology, 2018-06, Vol.314 (6), p.F1046-F1061

2018

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The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

Nature communications, 2021-07, Vol.12 (1), p.4651-15, Article 4651

2021

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Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment

Biochimica et biophysica acta, 2015-07, Vol.1849 (7), p.871-880

Koromilas, Antonis E.

2015

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mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

Nature communications, 2016-04, Vol.7 (1), p.11127-11127, Article 11127

2016

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The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Nature communications, 2017-03, Vol.8 (1), p.14638-14638, Article 14638

2017

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The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications

BioEssays, 2022-08, Vol.44 (8), p.e2200026-n/a

Koromilas, Antonis E.

2022

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PERK and PKR: Old kinases learn new tricks

Cell cycle (Georgetown, Tex.), 2008-05, Vol.7 (9), p.1146-1150

2008

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Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes

PloS one, 2012-04, Vol.7 (4), p.e34412-e34412

2012

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M(en)TORship lessons on life and death by the integrated stress response

Biochimica et biophysica acta. General subjects, 2019-03, Vol.1863 (3), p.644-649

Koromilas, Antonis E.

2019

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The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

Cell cycle (Georgetown, Tex.), 2012-11, Vol.11 (21), p.4069-4078

2012

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Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.E2149-E2155

2015

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Alternative ferritin mRNA translation via internal initiation

RNA (Cambridge), 2012-03, Vol.18 (3), p.547-556

2012

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AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization

Molecular pharmacology, 2016-10, Vol.90 (4), p.460-468

2016

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Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation

Cell cycle (Georgetown, Tex.), 2011-03, Vol.10 (5), p.794-804

2011

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A Unique ISR Program Determines Cellular Responses to Chronic Stress

Molecular cell, 2017-12, Vol.68 (5), p.885-900.e6

2017

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Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

The Journal of biological chemistry, 2014-05, Vol.289 (18), p.12593-12611

2014

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Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus

The Journal of biological chemistry, 2005-03, Vol.280 (10), p.9049-9057

2005

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Tyrosine Phosphorylation Acts as a Molecular Switch to Full-Scale Activation of the eIF2α RNA-Dependent Protein Kinase

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (1), p.63-68

2006

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STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A

Molecular cancer therapeutics, 2016-12, Vol.15 (12), p.3055-3063

2016

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Control of α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for eIF2α-Dependent Gene Expression and Cell Death

Molecular and Cellular Biology, 2004-04, Vol.24 (8), p.3415-3429

2004

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Resistance to Vesicular Stomatitis Virus Infection Requires a Functional Cross Talk between the Eukaryotic Translation Initiation Factor 2α Kinases PERK and PKR

Journal of Virology, 2004-12, Vol.78 (23), p.12747-12761

2004

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Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

Science signaling, 2011-09, Vol.4 (192), p.ra62

2011

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Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis

Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications

PERK and PKR: Old kinases learn new tricks

Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes

M(en)TORship lessons on life and death by the integrated stress response

The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs

Alternative ferritin mRNA translation via internal initiation

AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization

Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation

A Unique ISR Program Determines Cellular Responses to Chronic Stress

Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus

Tyrosine Phosphorylation Acts as a Molecular Switch to Full-Scale Activation of the eIF2α RNA-Dependent Protein Kinase

STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A

Control of α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for eIF2α-Dependent Gene Expression and Cell Death

Resistance to Vesicular Stomatitis Virus Infection Requires a Functional Cross Talk between the Eukaryotic Translation Initiation Factor 2α Kinases PERK and PKR

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

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